This Friday night’s NBA slate features a 2024-25 playoffs rematch between the Minnesota Timberwolves and the Los Angeles Lakers.
When Minnesota G Anthony Edwards and the Timberwolves head to Los Angeles this evening, they'll face G Luka Doncic and the Lake Show, who look to bounce back after a tough 119-109 loss to the Golden State Warriors on opening night. Tonight's game tips off at 10 p.m. ET on Prime Video at the Crypto.com Arena.
Below, we’ll break down our Timberwolves vs. Lakers prediction and NBA picks, including top player picks on PrizePicks' real money NBA DFS game, which includes Edwards, Doncic, and F Julius Randle.

Timberwolves vs. Lakers Prediction, NBA Picks
Minnesota Timberwolves Preview
- The Timberwolves are coming off a 118-114 win against the Portland Trail Blazers in their season opener.
- They shot 48.8% from the field and 50% (15-for-30) from 3-point range.
- Last season, Minnesota was 7-2 against the Lakers, including the playoffs.
Los Angeles Lakers Preview
- The Lakers came up short in their home opener against the Golden State Warriors, falling 119-109.
- L.A. had a tough time shooting from beyond the arc, connecting on just 25% of their treys.
- Lakers F LeBron James missed opening day for the first time in his 23-year career.
- James is expected to miss this Friday night's matchup against the Timberwolves. He could be out until mid-November.
Timberwolves vs. Lakers Picks for NBA DFS & PrizePicks
Here are three player picks for Timberwolves vs. Lakers on Friday night for PrizePicks' real money DFS NBA game, which includes Timberwolves G Anthony Edwards, F Julius Randle, and Lakers G Luka Doncic.
All you have to do is pick More or Less on these player projections — with thousands more to choose from — build your Lineup, click submit, and win real money if your picks hit.
Timberwolves G Anthony Edwards Projection vs. Lakers: 26.5 Points
- Edwards made history pouring in the most points ever scored in a Timberwolves season opener (41).
- In games he's played 35+ minutes against the Lakers during the 2024-25 season, the Ant Man averaged 26.8 points per game.
- In the Lakers’ season opener, they allowed Warriors F Jimmy Butler III to score the most points in his career in a season opener (31).
- Minnesota’s All-Star guard has a 34.7% usage rate and could see plenty of opportunities against a Lakers defense that ranked 15th in defensive rating (114.7) in 2024.
Timberwolves F Julius Randle Projection vs. Lakers: 6.5 Rebounds
- Randle has averaged 23.9 points, 8.9 rebounds, and 4.1 assists in 16 career games against the Lakers.
- In the 2024-25 season, the Minnesota forward averaged 7.1 rebounds per game.
- The former Kentucky Wildcat exceeded 6.5 rebounds in 42 of 69 regular-season games in 2024-25 (60.9%).
- The Lakers are coming off a season opener in which they allowed up 40 rebounds, with 9 of those coming on the offensive glass.
Lakers G Luka Doncic Projection vs. Timberwolves: 30.5 Points
- Much like Edwards, Doncic also made history by joining Lakers’ legends Kobe Bryant and Elgin Baylor as the only Lakers to record 40+ points in a season opener.
- Lakers’ franchise guard averaged 30.2 ppg over his last five games (2024-25 playoffs) against Minnesota, scoring 28+ points in three of those five games.
- The Slovenian superstar has scored 30+ points in 13 of his 29 games (44.8%) with the Lakers.
- With Doncic’s 34.7% usage rate (tied for seventh-most), the Lakers’ offense will likely run through him on Friday night.
Make NBA Picks on PrizePicks
Anthony Edwards and Luka Doncic will look to continue their respective scoring barrages in this marquee matchup on Friday from the Crypto.com Arena live on Prime Video at 10 p.m. ET.
As the NBA season starts to ramp up, PrizePicks is the place to be if you’re looking for some real money action on your NBA predictions.
With multiple different player stat projections to choose from on the NBA board, the opportunities are endless. All you need to do is pick More or Less on player stat projections, build your PrizePicks Lineup, lock it in, and win real money if your picks hit.
Stay in the game all season long for your NBA predictions for PrizePicks and DFS Lineups with Playbook.




