Another week, another set of ESPN Big Monday games for fans to enjoy. Spectators could pack Cameron Indoor Stadium in Durham, NC, for a nighttime ACC bout.
On Monday, the Syracuse Orange and Duke Blue Devils square off at 7:00 p.m. ET. With one side dominating the field and the other scuffling this season, there’s still plenty to play for in a conference clash.
Below, we’ll break down our Syracuse vs. Duke prediction and Monday college basketball picks. Make your college basketball picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
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Syracuse vs. Duke Prediction, Spread, Over/Under
Following a 14-19 season under head coach Adrian Autry, the Orange got off to a hot 12-5 start to this campaign. Unfortunately, they’re 3-6 ever since, seeing their NCAA Tournament hopes dwindle with each passing contest.
The Blue Devils, meanwhile, are a sparkling 23-2 on the year. Under fourth-year head coach Jon Scheyer, they’re 12-1 in ACC play and look poised to potentially make a run next month if things continue.
Monday marks the 24th meeting between Duke and Syracuse dating back to 1949-50. With the Blue Devils owning a commanding 17-6 series lead, it’s a lopsided rivalry.
Syracuse vs. Duke Over/Under, Spread
Syracuse enters Monday’s game as 20.5-point road underdogs, returning a 14.28x payout on PrizePicks Team Picks if they win outright.
Duke is a home favorite with a 1.01x payout if they win, via PrizePicks Team Picks.
- Spread: Duke Blue Devils -20.5
- Over/Under: 143.5
- Game Winner Payout: Orange 14.28x | Blue Devils 1.01x
Team Picks data is live at the time of writing and is subject to change.
Syracuse vs. Duke Prediction on Spread
Here are some stats to know to help you make your Syracuse vs. Duke prediction on Monday, February 16.
- Duke is a perfect 12-0 against the spread as home favorites this year, including a +24.6 average margin of victory. Syracuse is just 1-3 ATS as road underdogs.
- The Orange are outside the top 100 in per-game scoring on both offense (76.5 PPG, 136th) and defense (72.2 PPG, 108th).
- Poor team rebounding hurts Syracuse. Their average of 35 boards per night sits just 163rd, and they give up 36.8 on the other end — good for 294th.
- Duke is a downright punishing offense, scoring at the fourth-best clip inside the arc (61.9%) and ranking 24th in rebounds each night (39.7).
- Defensively, the Blue Devils hold foes to the second-lowest free throw to field goal ratio (.226) and the 12th-lowest effective field goal percentage (46.0).
Syracuse vs. Duke Picks for PrizePicks Today: 2/16/2026
Here are three top Syracuse vs. Duke picks to target for Monday, February 16 on PrizePicks. Player stat projections via PrizePicks are headlined by F Donnie Freeman, F Cameron Boozer, and G-F Isaiah Evans.
Syracuse F Donnie Freeman vs. Duke Projection: 20.5 Pts + Rebs
- Freeman averages a combined 24.8 points and rebounds. In his last five contests, however, that number is down to 20.6.
- Despite his usage remaining mostly the same, the sophomore’s turnover rate climbs 0.7% in conference play. His true shooting clip also drops 1%.
- According to KenPom, the Blue Devils boast the second-lowest defensive rating (89.4) among all Division I teams entering Monday’s play.
- Duke surrenders all of 29.8 boards per game, which ranks eighth in the nation.
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Duke F Cameron Boozer vs. Syracuse Projection: 22.5 Points
- On the year, Boozer pours in 22.8 points each night. Since the start of ACC play, he’s posting exactly 22.5.
- In conference outings, the true freshman’s PER spikes from a video game-like 34.4 to an insane 36.5. His true shooting percentage also increases from 65.9 to 66.6.
- Boozer leads all D-I players in adjusted points over replacement per game (7.4) and BPM (17.9).
- According to Bart Torvik, Syracuse allows the 112th-ranked effective field goal percentage (53.2) against top 50 programs.
Duke G-F Isaiah Evans vs. Syracuse Projection: 2.5 3-PT Made
- Evans jacks up 7.0 3-pointers on average, converting on 35.6% of them. In ACC clashes, those numbers rise to 7.5 and 37.1%, respectively.
- The sophomore wing ranks third among all ACC players in trey-balls hoisted per 100 possessions (14.7).
- Per CBB Shot Charts, 89% of Evans’ makes from deep are assisted. A whopping 87% of the 3-point makes Syracuse gives up are of that variety.
- Syracuse’s 3-point defense is nothing to write home about. The Orange yield a 32.5% clip on such looks, which sits 100th in college basketball.
Make Syracuse vs. Duke Picks on PrizePicks
Syracuse vs. Duke ACC picks are just one of many ways hoops fans can get in on the daily college basketball action.
You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states.
Stick around with the Playbook for continued CBB predictions, picks, and news.
