Marquette vs. #20 Michigan Prediction, Spread, CBB Picks – Wednesday, November 11

The 2026-27 college basketball season is off to an exciting start, and Wednesday night features an intriguing nonconference matchup when the Marquette Golden Eagles travel to Ann Arbor to take on the #20 Michigan Wolverines at Crisler Center.

Tip-off is set for 7 p.m. ET on FS1, with the Wolverines entering as 3.5-point favorites on PrizePicks.

Marquette has been dominant through its first two games, taking down Mercyhurst 78-43 and Detroit Mercy 93-32. Michigan opened with an 84-68 victory over Oakland before suffering an 85-77 loss to #4 UConn. Can the Wolverines defend home court against another quality opponent?

Below, we'll break down our Marquette vs. Michigan prediction and picks for Wednesday's college basketball game, including the spread, over/under, and more from PrizePicks.

Make your Marquette vs. Michigan picks on PrizePicks now!

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Marquette vs. #20 Michigan Prediction, Spread, Over/Under – Wednesday, November 11

The Wolverines enter Wednesday's matchup as 3.5-point home favorites against the Golden Eagles, returning a 1.53x payout if they win outright.

Here are the full payouts for Marquette vs. Michigan on PrizePicks.

Make your Marquette vs. Michigan prediction on the spread or over/under on PrizePicks.

PrizePicks data is live at the time of writing and is subject to change.

Marquette has been particularly impressive on defense, allowing just 37.5 PPG, a 25.6% mark from the field, and a 16.4% clip from 3-point range.

Both of the team's opponents are ranked outside the top 300 in KenPom’s ratings, however, so take the defensive metrics with a grain of salt for now.

Michigan has averaged 80.5 PPG while shooting 42.5% from the field. Its biggest offensive concern has been 3-point shooting, as the Wolverines are connecting on just 22.6% of their attempts from beyond the arc.

This is a Michigan team facing significant roster turnover given the high-end talent it lost to the NBA after last year’s championship run. The Wolverines have received excellent production from G Trey McKenney and F J.P. Estrella.

McKenney is averaging 19.5 PPG, while Estrella's posted 17.0 PPG and 10.5 rebounds per contest.

A key difference between these teams is strength of schedule. Michigan has already faced Oakland (230th nationally on KenPom) and UConn (10), while Marquette's opening foes are 314th and 315th.

That makes Wednesday's game an important measuring stick for both programs, but particularly the Golden Eagles.

Marquette vs. Michigan Prediction on Spread – 11/11/26

Here are the key stats and trends behind our Marquette vs. Michigan pick against the spread on Wednesday night.

Unless otherwise noted, data used in this article is from KenPom, Bart Torvik, and official team athletics pages.

• The Wolverines are 26th nationally in adjusted offensive efficiency (117.8), compared to Marquette at 42nd (116.2). Michigan has also shown it can generate offense against teams with significantly better defensive personnel than the Golden Eagles' opponents.
• After adjusting for competition, Michigan is 18th nationally in defensive efficiency (95.9), while Marquette ranks 13th (95.3). That's not much of a difference considering the praise this Marquette defense has gotten.
• The Wolverines scored 77 points against UConn despite shooting just 7-of-31 from 3-point range. Now back in front of the home crowd, perhaps there's some positive regression in store for Michigan.
• The Golden Eagles have grabbed 50.7% of their available offensive rebounds against inferior frontcourts. Michigan has more size available with Estrella and C Moustapha Thiam, making it potentially more capable of limiting second-chance opportunities.
• Michigan's defense on the interior is stifling, ceding just a 40.0% mark inside the arc.

Lock in your Marquette vs. Michigan prediction on PrizePicks before tipoff.

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Make Marquette vs. Michigan Picks on PrizePicks

Wednesday's matchup provides an early-season test for two programs looking to establish themselves as legitimate contenders. The Wolverines have a stronger resume, but Marquette's rebounding and defensive activity make this an intriguing tilt.

Don't wait until tipoff — make your Marquette vs. Michigan picks on PrizePicks. Just pick players, predict More or Less on their stats, and cash in if you're right. With Team Picks, you can make predictions on game winners, spreads, and over/unders.

Keep it here with the Playbook for continued college basketball picks, predictions, futures, and more throughout the season.