Steelers vs. Bills Prediction, NFL Preseason Picks – Thursday, August 27

The final week of the NFL preseason begins on Thursday, August 27, with four games on the schedule. The night gets started when the Buffalo Bills host the Pittsburgh Steelers at 7:00 p.m. ET.

The Bills have won each of their two preseason games, including a 31-7 triumph against the Cleveland Browns in Week 2. Meanwhile, the Steelers are 1-1 this preseason, falling 17-0 at the hands of the New York Jets last week. With the Bills expected to play some of their starters, Buffalo returns a 1.58x payout with a win on PrizePicks Team Picks.

Below, we'll break down our Steelers vs. Bills prediction and picks for Thursday’s NFL preseason game, including the spread, over/under, and key player picks for PrizePicks.

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Steelers vs. Bills Prediction, Spread, Over/Under for NFL Preseason – Thursday, August 27

The Bills enter Thursday’s game as 2.5-point home favorites against the Steelers, returning a 1.58x payout on PrizePicks Team Picks if they win outright.

Here are the full payouts for the Steelers vs. Bills NFL preseason game on PrizePicks.

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Payouts show potential returns on correct Team Picks predictions. A 2x payout returns $200 on a $100 entry. Lower multipliers reflect outcomes users are picking as more likely. Payouts are live as of writing and subject to change.

Steelers vs. Bills Prediction on Over/Under for NFL Preseason – 8/27/26

Here are the key game stats and trends behind our Steelers vs. Bills prediction on the over/under for Thursday's NFL preseason game. 

• Bills head coach Joe Brady said he expected some of the team’s starters to play against the Steelers, but QB Josh Allen won’t play.
• With Allen sitting out Thursday’s contest, veteran QB Kyle Allen will get the start and likely receive a considerable amount of snaps.
• As for the Steelers, head coach Mike McCarthy stated that starters could play in Thursday’s preseason finale. At the very least, QBs Drew Allar and Will Howard will likely receive significant playing time.
• Buffalo has averaged 30.0 points per game in its first two preseason games. In addition, the Bills scored at least 23 points in two of their three games during the 2025 preseason.
• There have been at least 38 points scored in four of the last five meetings between the Bills and Steelers.
• According to SumerSports, the Steelers surrendered 0.03 EPA per pass play in 2025, ranking 18th in the NFL.

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Steelers vs. Bills Picks, Player Stats for NFL Preseason on PrizePicks

Here are the top Steelers vs. Bills picks to target on Thursday, August 27. Today’s NFL preseason picks for PrizePicks include QB Kyle Allen, QB Drew Allar, and WR Germie Bernard.

Bills QB Kyle Allen vs. Steelers: 95.5 Passing Yards 

• Allen registered at least 108 passing yards in each of his 2026 preseason games, including completing 10 of 12 passes for 128 yards and a TD against the Browns last week.
• The veteran signal caller has topped the 100-passing-yard mark in four of his last five preseason contests.
• Allen has completed a staggering 85.7% (24 of 28) of his passes during the 2026 preseason.
• The Steelers’ secondary surrendered 226 passing yards and 2 TDs in a 17-0 loss to the Jets last week.

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Steelers QB Drew Allar vs. Bills: 95.5 Pass Yards 

• Allar passed for at least 110 yards in both of the Steelers’ 2026 preseason.
• In Week 2, the Penn State product completed 11 of 23 passes for 110 yards but didn’t register a TD or INT.
• According to PlayerProfiler, Allar recorded a 69.6 QBR in his final season with the Nittany Lions, ranking 26th in college football.
• The Bills recorded sacks 6.79% of the time, which ranked just 14th in the NFL.

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Steelers WR Germie Bernard vs. Bills: 20.5 Receiving Yards

• Bernard caught 4 passes for 51 yards on a team-high 5 targets against the Packers in Week 1 of the preseason.
• In his final season at Alabama, Bernard registered a 22.7% target share, which ranked 22nd in the country.
• Bernard utilized his speed on a 25-yard catch-and-run in the preseason opener.
• The Steelers’ rookie could make a push to be the third wideout in three-WR sets during the regular season, leapfrogging WR Roman Wilson with a strong performance in Thursday’s preseason finale.

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While it’s unclear if the Steelers will play their starters in Thursday’s preseason finale, QB Drew Allar is expected to see a significant amount of playing time. Meanwhile, the Bills are slated to play some of their starters in the final dress rehearsal before the regular season.

Don’t wait until kickoff at 7:00 p.m. ET—make your Steelers vs. Bills picks on PrizePicks now and earn real money if you’re right.

Pick NFL players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on preseason NFL game winners, spreads, over/unders, and NFL futures, now available in 36 states.

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