Spain vs. USA Prediction, Picks for FIBA World Cup – Saturday, September 12

The Spain vs. USA Women's National Team game is set to tip off at 2:00 p.m. ET on Saturday, September 12, with the USA entering as a 22.5-point favorite on the spread while returning a 1.02x payout to win, via PrizePicks.

The USA can qualify for a fifth-straight FIBA World Cup gold medal game with a win over Spain later this afternoon. The tournament favorites breezed through the group stage before a dominant 52-point win over Hungary in the quarterfinals.

The Stars and Stripes now take on a Spain side that has lost just once in the competition and arrives following a blowout victory over Australia on Thursday afternoon. Spain has reached the quarterfinals for the first time since 2018, when they finished third in the FIBA World Cup they hosted.

Below, we'll break down our Spain vs. USA prediction and picks for Saturday’s FIBA World Cup game in the round, including the spread and key player picks for PrizePicks.

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Spain vs. USA Prediction for FIBA World Cup – Saturday, September 12

Team USA followed up their worst-ever shooting game in FIBA history with back-to-back 100-plus point performances to advance to the semifinals on Saturday afternoon. Kara Lawson's squad remains the favorite to win the competition on PrizePicks with a 1.17x payout to claim a fifth consecutive gold medal.

Even so, FIBA has moved the USA to second in their official power rankings after France's dominant run through the tournament.

Before turning their attention to the new No. 1 ranked side, Team USA must first get past a Spain squad that has looked impressive throughout. The European side has lost just one of four games and enters the quarterfinals off a 23-point win over Australia.

Miguel Méndez's squad is averaging 81.0 PPG — third only to France and the USA — led by Iyanna Martin, who is averaging 16.5 PPG and ranks seventh in scoring.

While Spain has played well, they arrive as significant underdogs against the star-studded Americans. Spain has lost all five previous meetings with the USA, including a 77-64 defeat in the 2014 FIBA World Cup Final.

Spain vs. USA Winner Payouts, Spread, Over/Under – Saturday, September 12

The USA to win outright returns a 1.02x payout, as they are a decisive 22.5-point favorite on the spread.

Here are the full payouts for the Spain vs. USA game on PrizePicks.

Make your Spain vs. USA prediction on the spread on PrizePicks!

Team Picks data is live at the time of writing and is subject to change.

FIBA World Cup: Spain vs. USA Prediction Against the Spread – 9/12/26

Here are the key game stats and trends behind our Spain vs. USA prediction on the spread in the FIBA World Cup on Saturday, September 12.

• Team USA entered all four games as heavy favorites and delivered in all but one. Saturday’s favorites are winning by an average margin of +32.3 per game over four games.
• USA (90.5) and Spain (81.0) rank second and third, respectively, in PPG for the competition. 
• The USA has the best defense in the tournament, allowing just 58.3 PPG to opponents and posting a 75.8 defensive rating in their four wins.
• Spain is knocking down 35.4% of their 24.0 3-point attempts per game in the competition. The USA has held its opponents to just 16.0% shooting from the outside.
• Team USA’s 108 points scored on Hungary in the quarterfinals marked the highest-scoring game by a team at that stage of the tournament. The USA is the only team to have surpassed the century mark twice in the the same FIBA World Cup.

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Spain vs. USA Player Picks, FIBA World Cup Stats for PrizePicks – 9/12/26

While picks on the game are sparse, with the USA as such a large favorite, players are an easy way to get in on the Saturday afternoon action in Spain vs. USA.

Here are the top Spain vs. USA picks to target on PrizePicks for Saturday, September 12. Today's FIBA World Cup picks for PrizePicks include Awa Fam and Angel Reese.

Spain C Awa Fam vs. USA: 12.5 Points

• Fam ranks second on the team with 11.5 PPG in her four FIBA games. The 20-year-old Spaniard opened the competition averaging 12.3 PPG in the group stage.
• The Seattle Storm big struggled during Spain’s blowout victory over Australia, scoring just 9 points while making only 2 of 8 field goal attempts.
• Team USA is allowing 11.0 PPG to opposing centers thus far.
• Fam leads all Spain players with 24.7 minutes per game despite starting games on the bench. The 20-year-old shoots 45.0% from the field and ranks second in field goal attempts per game (10.5).

Add Awa Fam to your PrizePicks lineup now.

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USA F Angel Reese vs. Spain: 16.5 Pts + Rebs + Asts

• Reese has carved out a solid bench role for Team USA, averaging 8.8 PPG and shooting a team-high 63.2% from the field in 17.4 minutes per contest.
• The Atlanta Dream big has brought her rebounding prowess over from the WNBA, averaging 6.0 rebounds per contest, the second-most on the team. Her 3.3 offensive boards per game lead Team USA.
• Reese is getting to the line more than anyone, shooting 4.8 free throw attempts per game.
• The 24-year-old is averaging 15.6 PRA through four games but is coming off an 18 PRA performance in the quarterfinals over Hungary.

Add Angel Reese to your PrizePicks lineup now.

Make Spain vs. USA FIBA World Cup Picks on PrizePicks

Team USA is widely expected to advance to their fifth consecutive FIBA World Cup final with another potential dominant win over Spain later today. Should they get past the Spanish side, Lawson's squad will face the winner of France vs. Germany in the gold medal game.

Don’t wait until tip-off — make your Spain vs. USA picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

Stay locked in on Playbook for daily FIBA predictions, picks, and news every Saturday all the way through the FIBA World Cup Final.