The first round of the 2026 NCAA Tournament begins on Thursday, March 19, as No. 1 seed Duke (32-2) battles No. 16 seed Siena (23-11). Fresh off an ACC Tournament title, the Blue Devils will look to start their run on a strong note as 28.5-point favorites, via PrizePicks Team Picks.
Let’s take a closer look at a Siena vs. Duke prediction on the spread for this NCAA Tournament showdown in Greenville, SC, tipping off at 2:50 p.m. ET on CBS. Make your college basketball picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
New users on PrizePicks can start the 2026 NCAA Tournament with $50 in Lineups instantly after playing $5+ — win or lose! Just sign up with promo code PLAYBOOK and you’re good to go.
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Siena vs. Duke Prediction, Spread, Over/Under
The Blue Devils are one of the favorites to win the 2026 NCAA Tournament, returning a 4x payout on PrizePicks Team Picks. Duke only lost two games all season by a grand total of four points and hasn’t been defeated since falling to North Carolina, 71-68, on February 7.
Duke is currently riding an 11-game winning streak and has outscored its opponents by an average margin of 18.4 points during that stretch. F Cameron Boozer is one of the most polarizing players throughout the tourney after leading Duke in points (22.5), rebounds (10.5), and assists (4.2) per game.
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Duke has only faced Siena once in its history. The Blue Devils came away with a 92-74 win at Cameron Indoor Stadium in 2015, but they didn’t cover the spread as 24.0-point favorites.
Siena vs. Duke Spread, Over/Under
The Blue Devils enter this matchup as 28.5-point favorites, returning a 1.96x payout on PrizePicks Team Picks if Duke covers the spread.
Meanwhile, Siena is an underdog with a 1.78x payout if the Saints cover the spread, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Duke Blue Devils -28.5 (1.96x payout)
- Over/Under: 135.5 (1.85x payout on over)
- Game Winner Payout: Duke N/A | Siena 22.22x
Team Picks data is live as of writing and is subject to change.
Siena vs. Duke Prediction on Spread – 3/19/26
Here are some key stats to know before locking in your Siena vs. Duke prediction against the spread for the NCAA Tournament matchup on Thursday, March 19, on PrizePicks.
- Duke has a 17-15 against-the-spread record, producing a 53.1% cover rate. The Blue Devils are 7-5 ATS when favored by double digits in their last 12 games.
- The Blue Devils are 6-3 ATS in their last two NCAA Tournament stretches.
- According to Bart Torvik, Duke has recorded an adjusted offensive efficiency of 119.0, ranking seventh in the nation.
- The Blue Devils allow the third-fewest PPG (63.1) in the country, behind only Northern Iowa (61.3) and Houston (62.9).
- The Saints have knocked down just 30.4% of their shots from deep this season, second-to-last in the MAAC.
- Siena secures 34.4 rebounds per game, ninth in the MAAC. Meanwhile, Duke is tied for 10th in the nation with 40.3 rebounds per contest.
- Duke holds its opponents to 30.4% shooting from beyond the arc (18th).
- Boozer has averaged 22.4 PPG and is shooting 45.0% from 3-point land over his last five games.
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Think Duke F Cameron Boozer gets on the board in the first round vs. Siena? Boozer to score 1+ point — that’s the play for Thursday's first-round game. Claim the Max Discount promo here!
PrizePicks is running a special college basketball Max Discount promo for March 19, dropping Boozer’s points projection to 0.5. One point, and you’ve got a W in your Lineup.
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Boozer has been one of the most popular players on PrizePicks all season. His lowest-scoring game of the year was 13 points on a tough shooting night in the ACC Championship.
Looking for more ways to build your Lineup around Boozer? The Playbook has college basketball picks and predictions for every NCAA Tournament matchup.
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Make Siena vs. Duke Picks on PrizePicks
Duke has been battle-tested throughout the 2025-26 season and recently won an ACC Tournament title. Can the Blue Devils keep that strong momentum going as the 2026 NCAA Tournament begins?
You can make your Siena vs. Duke picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
Check out the Playbook throughout the 2026 NCAA Tournament for more college basketball predictions, picks, and news every day.
