Last week, we saw the landscape of college football shift dramatically. Georgia, Alabama, and Vanderbilt elevated themselves, while others fell a step behind in College Football Playoff contention.
Week 9 isn't as loaded as the week prior, but we still have plenty of enticing Saturday college football matchups for CFB DFS, including No. 8 Oklahoma vs. No. 13 Ole Miss — with only one team leaving this game still in SEC Championship contention.
Below, we'll give you the top Saturday CFB DFS Picks for Week 9 on PrizePicks, including player stats and picks for the premier college football matchups in the PrizePicks cheat sheet.
The SEC has the must-see matchups of the weekend, starting with Ole Miss vs. Oklahoma at 12 p.m. ET on ABC. We’ll see if Rebels head coach Lane Kiffin can get his team refocused after suffering its first loss of the season.
No. 10 Vanderbilt is riding the momentum of its biggest win of the year against then-No. 10 LSU and now hosts No. 15 Missouri at 3:30 p.m. ET on ESPN. Week 9 concludes with the last undefeated team in the conference, No. 3 Texas A&M, traveling to Baton Rouge to take on No. 20 LSU, who cannot afford another loss, or their pPlayoff chances are likely over.
Below, we'll dig into the projections to target for players in each of these college football matchups, including Heisman candidates QBs Ty Simpson and Marcel Reed, plus many more QBs, RBs, and WRs to target this week.
PrizePicks is the simplest way to win real money with your CFB picks this Saturday and every week. Just pick your players, predict More or Less on their stats, and cash in when your picks are correct.
Let's dive into the top college football DFS picks for Saturday, October 25, on PrizePicks.
Week 9 Saturday CFB DFS Picks for PrizePicks
Here are the top CFB DFS picks for Saturday, October 25, in Week 9 of college football, including PrizePicks picks for Ole Miss vs. Oklahoma and Alabama vs. South Carolina in the SEC.
Use this analysis to build your PrizePicks CFB Lineups for Saturday's Week 9 games.
Alabama QB Ty Simpson Projection: 265.5 Passing Yards
No. 4 Alabama vs. South Carolina Pick – 3:30 p.m. ET
- Alabama QB Ty Simpson has more than 265 yards in three of his last five games.
- The junior is averaging 279.5 yards during the Crimson Tide’s six-game winning streak.
- Simpson is fourth in EPA per dropback (0.35).
- South Carolina is 45th in pass EPA (-0.050).
- The Gamecocks are allowing the fourth-fewest passing yards per game in the SEC (186.1).
- Alabama leads the SEC in pass EPA (0.306).
- When South Carolina faced Vanderbilt, the No. 2 team in pass EPA, they allowed 177 total passing yards.
Texas A&M QB Marcel Reed Projection: 250.5 Pass+Rush Yards
No. 3 Texas A&M vs. No. 20 LSU Pick – 3:30 p.m. ET
- Marcel Reed has more than 250 pass+rush combo yards in three of his last five games.
- Reed has emerged as a top Heisman candidate.
- Texas A&M is 13th in scramble rate (12.4%).
- LSU is 126th in opponents’ scramble rate (10.4%).
- The Tigers are ranked 75th in yards after contact to quarterbacks (3.5).
- Reed recently faced Florida, which is 106th in yards after contact, where he had 30 yards after contact.
- The sophomore’s best opponent in overall EPA was Notre Dame (14th) in Week 3, where he had 397 pass+rush yards.
Ole Miss QB Trinidad Chambliss Projection: 294.5 Pass+Rush Yards
No. 8 Ole Miss vs. No. 13 Oklahoma Pick – 12 p.m. ET
- Trinidad Chambliss has more than 294 pass+rush combo yards in four of his last five games.
- Chambliss is the only quarterback this season to throw for 300+ yards and rush for 60+ yards in three straight games.
- Oklahoma is fourth overall in opponents' EPA (-0.207).
- Chambliss has yet to face an opponent ranked in the top 15 in defensive EPA.
- The Sooners have allowed one quarterback in seven games to have more than 200 pass+rush yards this season.
- OU has forced two quarterbacks to rush for negative yards thanks to the third-best pressure rate in the country (43.0%).
Indiana RB Kaelon Black Projection: 45.5 Rushing Yards
UCLA vs. No. 2 Indiana Pick – 12 p.m. ET
- Kaelon Black has more than 45.5 rushing yards in three of his last five games.
- Black’s 6.0 yards per carry is 24th among running backs with a minimum of 70 carries.
- The UCLA Bruins allow 5.1 yards per carry, which ranks 118th.
- The senior has a 47% rush success rate.
- UCLA ranks 135th in opponents' rush success (49.0%).
- The Bruins allowed two or more players to rush for more than 45 yards in six of seven games.
Ole Miss RB Kewan Lacy Projection: 72.5 Rushing Yards
No. 8 Ole Miss vs. No. 13 Oklahoma Pick – 12 p.m. ET
- Kewan Lacy has less than 72 rushing yards in three of his last five games.
- The sophomore is coming off a season-low 31 rushing yards against Georgia, which is 15th in rushing yards allowed per game.
- Oklahoma is third in rushing yards allowed per game with 74.3.
- The former three-star recruit is 21st in carries of 10+ yards (8).
- Oklahoma has allowed 16 carries of 10+ yards, which ranks eighth in the country.
- Lacy has rushed for under 4 yards per carry in four of five games.
- The 2.3 yards per carry Oklahoma is allowing is the second-lowest in the country.
Missouri WR Kevin Coleman Jr. Projection: 53.5 Receiving Yards
No. 15 Missouri vs. No. 10 Vanderbilt Pick – 12 p.m. ET
- Kevin Coleman has more than 53 receiving yards in three of his last five games.
- The senior has 19 more catches (44) and 127 more receiving yards (449) than the next Missouri pass catcher.
- The only two games this season in which Coleman had fewer than 53 receiving yards were against Alabama and South Carolina, both of which rank in the top 25 in passing yards allowed per game.
- Vanderbilt is 91st in passing yards allowed per game.
- The Commodores have allowed a receiver to go for more than 70 yards in four straight games.
- Coleman will likely be lined up against Vanderbilt CB Randon Fontenette, who has allowed 11.2 yards per reception over his last three games, per PFF.
Make College Football DFS Picks on PrizePicks
With three games between top 25 teams, Week 9 of college football could be an important weekend with the CFB Playoff schedule set to come out in two weeks.
Whether you're watching the SEC matchup between Missouri and Vanderbilt or Ole Miss and Oklahoma, PrizePicks is the best way to cash in on your college football picks.
Just pick your players — including Ty Simpson and Marcel Reed — predict More or Less on their stat projections, and get paid when your picks are correct on PrizePicks CFB.
Stay locked in on the Playbook for more CFB DFS picks and college football predictions throughout the 2025 season.
