Rams vs. Chargers Prediction, NFL Preseason Picks – Thursday, August 27

The final week of the NFL preseason is upon us, with four matchups on Thursday, August 27, including the battle of Los Angeles. The Los Angeles Rams and Los Angeles Chargers match up under the bright lights of SoFi Stadium, kicking off at 10:00 p.m. ET on NFL Network.

The Chargers are a considerable favorite on PrizePicks Team Picks and return a 1.56x payout with an outright victory. That favorite status primarily comes from the Chargers being the only team expected to play any starters, with an expectation of “6 to 9” plays for their first-stringers. — ADD LINK

Below, we'll break down our Rams vs. Chargers prediction and picks for Thursday’s NFL preseason game, including the spread, over/under, and key player picks for PrizePicks.

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Rams vs. Chargers Prediction, Spread, Over/Under for NFL Preseason – Thursday, August 27

The Chargers enter Thursday’s game as 3.5-point favorites against the Rams, returning a 1.56x payout on PrizePicks Team Picks if they win outright.

Here are the full payouts for the Rams vs. Chargers NFL preseason game on PrizePicks.

Make your Rams vs. Chargers prediction on the spread or over/under on PrizePicks Team Picks—available in 36 states!

Payouts show potential returns on correct Team Picks predictions. A 2x payout returns $200 on a $100 entry. Lower multipliers reflect outcomes users are picking as more likely. Payouts are live as of writing and subject to change.

Rams vs. Chargers Prediction on Spread for NFL Preseason – 8/27/26

Here are the key game stats and trends behind our Rams vs. Chargers prediction on the spread for Thursday, August 27’s game. 

• Despite not playing their starters, the Rams have been incredibly impressive in the preseason. They beat both the Chiefs and Saints as outright underdogs and will look to do the same against the Chargers tonight.
• QB Ty Simpson, who will likely get an extended leash tonight, has shown to be a fantastic fit in McVay’s QB-friendly system. Against the Chiefs, he went 21-of-25 for 190 yards and 2 TDs.
• QB Stetson Bennett will not play as much as Simpson tonight. If he gets in the game, he, too, has been very impressive, with a 19-of-31 performance for 181 yards and two rushing TDs vs. New Orleans last week.
• While the Chargers will feature starters for “6 to 9 plays,” that is essentially just one drive, and the backup QB edge could firmly go to the Rams.
• The Chargers QBs Trey Lance and DJ Uiagalelei strike little fear, especially considering the weak run game the Chargers have shown thus far.
• LAC has averaged just 3.4 and 3.6 yards per carry in their respective games, while LAR popped off for 4.4 and 5.0 yards per rushing attempt in each game.
• The Rams' defensive depth has been on full display this preseason as well. Last week, they held a Saints QB pairing of Zach Wilson and Spencer Rattler, both former NFL starters, to a combined 20 of 35 for 188 yards and 2 INTs. The Saints scored 0 points in that game.

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Rams vs. Chargers Picks, Player Stats for NFL Preseason on PrizePicks: 8/27/26

Here are the top Rams vs. Chargers picks to target on Thursday, August 27. Today’s NFL preseason picks for PrizePicks include K Harrison Mevis and QB Justin Herbert. 

Rams K Harrison Mevis vs. Chargers: 1.5 PAT Made

• Mevis has cleared this projection in both preseason games thus far, nailing 6 combined extra points each game with a 100.0% success rate.
• The Rams' offense has shown the ability to move the ball with great success, even with mostly depth pieces; they should have few problems punching it into the end zone a few times tonight.
• The Chargers defense showed little resistance in their last outing against the 49ers, conceding 5 touchdowns and 41 points, leading to K Eddy Piniero nailing 5 PATs.
• Mevis is an incredibly consistent kicker; in college, he made 148 of 149 (99.3%) extra point attempts throughout his career.

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Chargers QB Justin Herbert vs. Rams: 25.5 Pass Yards

• We don’t have much of a sample size to work off with Herbert, as he has only attempted 2 throws this preseason, going 1 of 2 for 9 passing yards.
• However, this leads me to believe that HC Jim Harbaugh and new OC Mike McDaniel are eager to let their QB get into a bit of a rhythm before the regular season gets underway.
• If we read the tea leaves a bit, it seems both coaches would like to see their starters put forth a better effort than they did in their last outing. This could lead to more attempts from their star QB.
• OC Mike McDaniel is historically a pass-first offensive coordinator, with a lifetime pass rate of 59.0% compared to just 41.0% on the ground.
• Here are the puzzle pieces: 6 to 9 plays (let’s call it 8), a 59.0% pass rate (let’s say 5 passes), and Herbert’s 7.2 career yards per pass attempt. There appears to be a relatively easy path to him clearing this 25.5-yard projection.

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The Rams have shown that not only do they have elite top-end talent, but their depth pieces are also more than reliable. QB Ty Simpson will get his final chance at making a legit pass as QB Matthew Stafford’s backup this season. Can they pull off the perfect 3-0 preseason before embarking on their long flight to Australia for the regular season opener?

Don’t wait until kickoff for more preseason football—make your Rams vs. Chargers picks on PrizePicks now and earn real money if you’re right.

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