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Pistons vs. Bulls Prediction, Spread, Picks: Back Cade Cunningham on the Road?

Detroit Pistons PG Cade Cunningham reacts to converting an and-one against the Brooklyn Nets.
AP Photo/Heather Khalifa

Two teams traveling at warp speed in opposite directions meet up tonight when the Detroit Pistons (41-13) roll into the Windy City to take on the Chicago Bulls (24-32). This will be the fourth meeting between these two teams this season, with Detroit owning a 2-1 series lead.

Pistons vs. Bulls tips off at 8:00 p.m. ET on Saturday from Chicago, IL, live on NBA League Pass.

Below, we’ll break down our Pistons vs. Bulls prediction and Saturday NBA picks for PrizePicks. Use PrizePicks NBA to make picks on player projections and win real money if you’re right.

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Pistons vs. Bulls Prediction, Spread, Over/Under

The Pistons remain the best story in the NBA. This was a team that just two years ago went 14-68 and had the worst record in the NBA by a whopping 7 games. They finished 50 games behind the Eastern Conference-leading Boston Celtics that year.

Fast forward two campaigns, and Detroit now leads the East themselves and boasts the best record in the NBA. They’ll look to continue their strong play tonight and wrap up a four-game road trip a perfect 4-0.

It’s been a turnaround of epic proportions for this young and talented Detroit Pistons team. A "Yes” prediction on them to hoist this year’s Larry O’Brien Trophy is currently returning an 8.33x payout on PrizePicks Team Picks.

The Bulls, meanwhile, are in free-fall mode right now. They sit at 24-32 and currently occupy the 12th seed in the East. They've lost seven straight games and are 1-9 over their last 10. Chicago was, however, incredibly active at the trade deadline, acquiring a bevy of guards, including former Pistons G Jaden Ivey, whom they proceeded to DNP in their last game.

This is a team that has seemingly been in flux for the better part of this decade, and now they’re trending from average to bad fast.

Pistons vs. Bulls Spread, Over/Under

The Pistons enter Saturday’s game as 10.5-point road favorites, returning a 1.17x payout on PrizePicks Team Picks if they win outright.

The Bulls are sizable home underdogs with a 4.54x payout if they win, via PrizePicks Team Picks.

  • Spread: Detroit Pistons -10.5 (1.81x payout)
  • Over/Under: 232.5 (1.85x payout on over)
  • Game Winner Payout: Pistons 1.17x | Bulls 4.54x

Team Picks payouts are live as of writing and are subject to change.


Pistons vs. Bulls Injury Report

Let’s dive into the full Pistons vs. Bulls injury report for Saturday, via NBA.com.

Detroit Pistons Injury Report

  • PF Tolu Smith (knee): Questionable
  • C Isaiah Stewart (league suspension): OUT

Chicago Bulls Injury Report

  • PF Zach Collins (toe): OUT
  • PG Jaden Ivery (knee): Questionable
  • PF-C Guerschon Yabusele (calf): Probable

Pistons vs. Bulls Prediction on Spread

Here are some stats to help you make your Pistons vs. Bulls prediction on the spread today.

  • The Pistons are a perfect 7-0-0 (100%) against the spread (ATS) as a road underdog.
  • The Bulls are 25-31-0 (44.6%) ATS, the ninth-worst record in the Association.
  • Detroit has the second-best net rating in the NBA (+8.4), and over its last 10 games, that number increases to +12.5.
  • Chicago, on the flip side, has the seventh-worst net rating (-4.2). In its last 10, that plummets to -12.7. That marks a whopping 25.2-point differential in net rating between the two franchises during this span.
  • There are many differences between these two teams, perhaps none greater than the work they do defensively. Detroit is second in the NBA with a defensive rating of 108.4, while Chicago is 25th at 117.4, according to NBA Advanced Stats.

Pistons vs. Bulls Picks for PrizePicks Today: 2/21/26

Here are two of the top Pistons vs. Bulls to consider for PrizePicks today. Player projections via the PrizePicks real-money NBA game.

Pistons PG Cade Cunningham vs. Bulls Projection: 41.5 Pts + Rebs + Asts

  • Cunningham is averaging 27.6 points per game on the road as opposed to 23.7 at home. He also snags 0.7 more rebounds per game away from home.
  • A large part of this scoring increase has been due to superior shooting. Cunningham is 5.7% more efficient from the field and 7.6% better from deep in road contests.
  • Chicago allows opponents to shoot 47.8% from the field, the eighth-worst mark in the league. They cede a 37.5% mark from 3-point range, the highest in the sport.
  • The Bulls' defense surrenders the ninth-most rebounds (44.9) and third-most assists (28.4) per game.

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Bulls F Matas Buzelis vs. Pistons Projection: 23.5 Pts + Rebs + Asts

  • Buzelis averages 22.5 points, rebounds, and assists (PRA) per game.
  • The young forward shoots 4.4% worse from the field and 9.6% worse from deep at home, leading him to averaging 1.2 fewer points in Chicago.
  • The Pistons' defense allows foes to shoot just 44.1%, the second-best percentage in the NBA.
  • Additionally, Detroit only gives up 41.1 rebounds (fourth) and 22.9 assists (first) each night.

Make Pistons vs. Bulls Picks on PrizePicks

The NBA is back and rolling after All-Star Weekend, and you can get all your action for the second half of the season on PrizePicks. Pistons vs. Bulls picks aren’t the only way hoops fans can get in on the daily action.

You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states. 

Stick around with the Playbook for continued NBA predictions, picks, and news.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Adi Narang is a professional sports bettor and New York University graduate in Sports Management. A lifelong Denver sports fan, he’s spent over a decade applying data-driven analysis to trends, pricing, and game-level predictions. He’s always up for a sports conversation — from a Nikola Jokić GOAT debate to Korean Baseball batting orders.

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