The Panthers and 49ers, two teams on the NFC playoff bubble, meet up on Monday Night Football in Week 12. The Panthers have won five of seven, while the Niners have alternated wins and losses since a 3-0 start. The NFC battle kicks off on Monday Night Football at 8:15 p.m. ET on ESPN.
Below, we'll break down our Panthers vs. 49ers prediction and Monday night picks for Week 12, including the top player picks on PrizePicks real money NFL game, including Panthers QB Bryce Young and Niners QB Brock Purdy and RB Christian McCaffrey.
Panthers vs. 49ers Prediction, Picks for Monday Night Football
The Panthers and Niners meet for the first time since San Francisco's 37-15 win in 2022. The teams have thrown down on Monday Night Football once previously in the Panthers first-ever MNF appearance, a 34-21 49ers win in 1997.
Carolina Panthers Preview
- The Panthers are over .500 this late in the season (6-5) for the first time since 2018, when they started 6-2 and lost their next eight games.
- Carolina is ninth in the NFL in rushing, averaging 127.1 rush yards per game.
- After starting the season 0-3 away from home, the Panthers have taken their last three road outings, winning at the Jets, Packers and Falcons. The last time Carolina took four straight roadies in the same season was their 15-1 campaign in 2015, when they went 7-1 outside of North Carolina.
- Despite the 5-4 record, the Panthers average 18.8 points per game, 28th in the NFL.
San Francisco 49ers Preview
- The Niners' pass offense is second in the NFL at 254.5 yards per game, while ranking 27th in rushing at 94.8 rush yards.
- The 49ers have scored 101 points in the last three weeks (33.7 PPG) after breaking 20 points three times in the first eight games.
- San Francisco’s defense lands 25th overall, allowing 352.9 yards per game, 28th against the pass (249.1), and 12th against the run (103.8).
Panthers vs. 49ers Picks for NFL DFS & PrizePicks
Here are three Panthers vs. 49ers player picks for Week 12 for PrizePicks real money NFL game, including Panthers QB Bryce Young and Niners QB Brock Purdy and RB Christian McCaffrey.
Pick More or Less on these projections on PrizePicks — plus thousands more —to win real money this NFL season.
Panthers QB Bryce Young Projection vs. 49ers: 204.5 Pass Yards
- Panthers QB Bryce Young threw for a career-high 448 yards last week vs. the Falcons. That game ended a streak of seven straight sub-200-yards passing performances.
- On the season, Young has failed to hit 200+ yards passing in eight of 10 games.
- Young had 3 TD passes last week, his third 3+ touchdown game of the season. In the other seven games, he has 5 total passing TDs.
- Young’s 86.0 passer rating is 23rd of 29 qualified QBs.
49ers RB Christian McCaffrey Projection vs. Panthers: 124.5 Rush + Rec Yards
- 49ers RB Christian McCaffrey failed to top 70 rushing yards in the first six games of the season and in nine of 11.
- CMC had 2 rushing TDs last week vs. the Cardinals and has 6 rushing TDs in the last six games after having 0 rushing TDs the first five games of 2025.
- The Stanford product has 3+ receptions and 6+ targets in all 11 games this season. In nine of the games, he has 5+ catches.
- The Niners RB ranks 13th in the NFL with 707 rushing yards and second in the NFL with 74 receptions.
49ers QB Brock Purdy Projection vs. Panthers: 252.5 Pass Yards
- 49ers QB Brock Purdy has only played in three games this season, and threw for 200+ in all three.
- The former Mr. Irrelevant has 7 total passing TDs in those three games, with 2+ in all three.
- Dating back to last season, Purdy has 2+ passing TDs in five straight and in six of his last seven.
- Adding Purdy and San Fran's QB2 Mac Jones' numbers together, the Niners' signal callers have thrown for 300+ passing yards in seven of 11 games this season.
Make Week 12 Football Picks on PrizePicks
Can the Panthers take over first place in the NFC South? Or will the Niners keep pace with the Rams and Seahawks in the crowded NFC West? The NFC battle kicks off on Monday Night Football at 8:15 p.m. ET on ESPN.
As the NFL season enters its 12th week, there's no better place to get real money action with your NFL predictions than on PrizePicks.
There is a wide variety of player stat projections on the NFL board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick at least two players and pick More or Less on their stats to build your Lineup on PrizePicks.
Check out the Playbook throughout the NFL season for more NFL predictions for your PrizePicks and NFL DFS Lineups.
