NFL Week 6 gives us a plethora of compelling matchups, starting with the surprising 4-1 Jacksonville Jaguars hosting the Seattle Seahawks; two 4-1 teams meeting in Tampa as the Buccaneers host the 49ers; the Lions and Chiefs meeting in primetime in what was once thought to be a potential Super Bowl preview; and the Atlanta Falcons hosting the Buffalo Bills in the first of two Monday Night Football games.
We'll dive deep into four Week 6 games with team and player stats to bring you key insights to make your picks and predictions this week, whether you're playing fantasy football or NFL DFS on PrizePicks.
🏈 Play $5, Get $50 in Lineups for your NFL Picks. Use PrizePicks Promo Code PLAYBOOK
Seattle Seahawks at Jacksonville Jaguars Picks & Stats to Know
- Seattle QB Sam Darnold has thrown 1+ passing TD in four of five games this season and in 12 of the past 14 overall, including his games with the Vikings last season.
- After seeing his output decrease in every game from Week 1 to Week 4, Jaxson Smith-Njigba climbed back to WR1 last week vs. the Buccaneers:
- Week 1: 13 targets, 9 receptions, 124 yards
- Week 2: 10 targets, 8 receptions, 103 yards
- Week 3: 6 targets, 5 receptions, 96 yards (TD)
- Week 4: 5 targets, 4 receptions, 79 yards
- Week 5: 9 targets, 8 receptions, 132 yards (TD)
- The Seahawks offense ranks fourth in defensive DVOA, per FTN Fantasy, while the defense ranks seventh.
- Seattle stands at fifth in the NFL at 245.4 pass yards per game and first at 8.96 pass yards per play.
- Darnold has passed for 215+ yards in four straight games since throwing for 150 yards in the opener.
- Seahawks RB snap counts through five weeks: Kenneth Walker III 134, Zach Charbonnet 131, rest of team 25, including 0 in Week 5.
- Jaguars QB Trevor Lawrence has failed to throw multiple TD passes in four of his five games this season. He had 3 TDs passes vs. the Bengals in Week 2.
- Jaguars RB Travis Etienne has rushed for 70+ yards in three of five games this season, with 56 and 49 yards in the other two.
- The Jaguars have rushed for 137 yards per game, fifth-best in the NFL.
Seahawks at Jaguars Picks to Target
Seahawks vs Jaguars projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- Seahawks QB Sam Darnold - 227.5 passing yards
- Seahawks WR Jaxon Smith-Njigba - 82.5 receiving yards
- Jaguars RB Travis Etienne - 65.5 rush yards
San Francisco 49ers at Tampa Bay Buccaneers Stats to Know
- Niners RB Christian McCaffrey has failed to top 70 rushing yards in any game this season. He recorded 79 in one of the four games last year, meaning he has no games of 80+ rush yards over the last two seasons.
- McCaffrey does have 6+ receptions and 7+ targets in all five games this season.
- Filling in for starter Brock Purdy, Niners QB Mac Jones has thrown for 275+ yards in all three games, with 6 passing TDs.
- San Francisco enters Week 6 averaging 290.6 pass yards per game, tops in the NFL. On the flip side, their rushing offense is t-28th at 85.2 yards per game.
- Buccaneers QB Baker Mayfield had 2 passing TDs last week against the Seahawks, the tenth time in 11 games with 2+ passing TDs. He had 2+ passing TDs in 13 of 18 games last season, including the playoffs and now in 29 of his 42 games played with the Bucs.
- Buccaneers WR MIke Evans missed the last two games, while WR Chris Godwin returned. The one constant has been rookie WR Emeka Egbuka, who has seen 4+ targets in all five games with 5 TDs.
- Egbuka has led the Buccaneers in receiving yards in four of the team’s five games this season. He leads the Bucs WRs with a 22.1 pct target share.
- RB Bucky Irving missed Week 5 with shoulder and foot injuries. He led the Buccaneers backfield with 70.2 pct of the team’s snaps through the first four games. In his place last week, Rachaad White led the team with an 80% snap count.
49ers at Buccaneers Picks to Target
49ers at Buccaneers projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- 49ers RB Christian McCaffrey - 62.5 rush yards
- Buccaneers QB Baker Mayfield - 1.5 passing TDs
- Buccaneers WR Emeka Egbuka - 66.5 receiving yards
Detroit Lions at Kansas City Chiefs Stats to Know
- During the 2023 and 2024 season, the Chiefs won an NFL-record 17 consecutive one-score games. This season, the Chiefs are 0-3 in one-score games.
- After averaging 315.6 yards per game the first three games of the season, KC has averaged 429.0 yards of offense in the last two, with WR Xavier Worthy’s return to the lineup.
- Including postseason, Chiefs TE Travis Kelce has failed to reach 70+ yards receiving in 14 of his last 16 games.
- Dating back to last season, Chiefs QB Patrick Mahomes has multiple TD passes in only two of his last eight games, including just once this season. Prior to that, Mahomes had thrown 2+ passing TDs in 10 of 20 games.
- The Lions lead the NFL with 34.8 points per game, hitting 34+ points in each of their last four outings. The offense ranks fourth in DVOA, per FTN Fantasy.
- Detroit have scored 30+ points in 10 of the last 11 games, dating back to last season.
- Lions QB Jared Goff leads the NFL with 12 TD passes and a 120.7 passer rating through five games. He's tenth in the league in passing yards, averaging 237.4 per game.
- Lions WR Amon-Ra St. Brown has had 6+ targets in 16 consecutive games, including the postseason.
- St. Brown’s 28.1% team target share is sixth in the NFL.
- Lions RB snap counts through 5 weeks: Jahmyr Gibbs 193, David Montgomery 126, Rest of team 25, including 0 last in Week 5.
Lions vs. Chiefs Picks to Target
Lions vs. Chiefs projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- Chiefs QB Patrick Mahomes - 1.5 passing TDs
- Chiefs TE Travis Kelce - 47.5 receiving yards
- Lions WR Amon-Ra St. Brown -74.5 receiving yards
Buffalo Bills at Atlanta Falcons Stats to Know
- Bills QB Josh Allen has 2+ TD passes in four of five games this season and in nine of his last 11, dating back to last season.
- Allen has rushed for 25+ yards in all five games this season and in 10 of his last 12, dating back to last season.
- Bills RB James Cook has 5 rushing TDs in five games this season. He had 3 rushing TDs in 3 postseason games last year and 5 over his final four regular season games of 2024, giving him 13 rushing TDs in his last 12 games.
- The Bills enter Week 5 averaging 30.6 points per game, third best in the league. They are also third in total yards (395.8) and second in rushing yards (154.4).
- While the Bills are near the top in most offensive categories, the Falcons defense leads the NFL in total defense, holding opponents to 244 yards per game. They also have the top passing defense at 135 pass yards per game.
- Per DVOA, the Falcons have the top defense in the NFL, ahead of Detroit, Green Bay, and Houston.
- After being held to 24 rushing yards in the season opener vs. Tampa Bay, Falcons RB Bijan Robinson has 70+ rushing yards in his last three games.
- Robinson has added 25+ receiving yards in all four games, hitting 100+ in two of the four games.
- Falcons TE Kyle Pitts has recorded 5+ targets and 4+ catches in all four games this season.
Bills vs. Falcons Picks to Target
Bills vs. Falcons projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- Bills QB Josh Allen - 1.5 passing TDs
- Bills RB James Cook - 0.5 rush + rec TDs
- Falcons RB Bijan Robinson - 26.5 receiving yards
Pick More or Less on NFL Week 6 Stats
The Buccaneers and 49ers meet as 4-1 teams in the NFC, Seattle goes west coast to east coast to face the surprising 4-1 Jacksonville Jaguars, and the Lions and Chiefs
— two of the better teams over the last five years — meet on Sunday night. Plus, the Bills and Falcons battle it out in the first of two Monday night games.
We hope these Week 6 picks and stats to know can help you make your picks and predictions on PrizePicks real money NFL game.
Simply pick your players, predict More or Less on their Week 6 stats, and win cash when you're right. It's the simplest way to play NFL DFS, all season long.
