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NBA Injury Report Today, 10/22: Anthony Edwards, Domantas Sabonis, Tyler Herro Updates

Timberwolves G Anthony Edwards dribbles a basketball in an NBA game.
AP Photo/Frank Franklin II

Here’s the NBA injury report for Wednesday, October 22, as the NBA season officially gets underway, including six NBA players listed as out, doubtful, or questionable for today's 12-game slate.

All injury designations are as of 10 a.m. ET. Projections are via the PrizePicks NBA real money game as of 11:30 a.m. ET, but are subject to change.

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NBA Injury Report Today for Key Players: Wednesday, 10/22/25

Here are the key injuries to note from Wednesday's NBA injury report before making your NBA picks on PrizePicks today.

As we enter the season, the list of players that will be missing is extensive, so be sure to stay tapped into how teams are moving without these players in.

Timberwolves SG Anthony Edwards vs. Blazers

Injury Status: Questionable (back)

Which Player Could Benefit: Shaedon Sharpe, Donte DiVincenzo

Not having to defend Edwards would make anybody’s offensive life easier. For the Wolves, Edwards' 31.3% usage is a significant gap to fill. Last season, Naz Reid was a benefactor, seeing his usage rise from 21% to 24.2% when he plays without Ant on the floor. Donte DiVincenzo would also see starter minutes if Ant sits.

Blazers G Shaedon Sharpe vs. Timberweolves Projections: 20.5 points, 4.5 rebounds


Cavaliers PG Darius Garland vs. Knicks

Injury Status: Out (toe)

Which Player Could Benefit: Lonzo Ball, Donovan Mitchell

When healthy, the former Laker and Bull is All-Star adjacent, and will look to hit that rare air in his Cavs debut, likely to draw the start at PG. Garland's 27.5% usage rate should be distributed mostly between SG Donovan Mitchell and PF Evan Mobley.

Cavs G Lonzo Ball vs. Knicks Projections: 7.5 points, 3.5 assists


Suns SG Jalen Green vs. Kings

Injury Status: Out (hamstring)

Which Player Could Benefit: Devin Booker

After Phoenix gutted their roster, Booker is beyond the alpha dog, and without his new backcourt sidekick, he’ll likely be expected to carry the team more than usual. Last year, without Kevin Durant (now on the Rockets) or Bradley Beal (now on Clippers) on the floor, Booker had a massive 33.6% usage rate, compared to 28.9% on the season.

With so many other changes to this roster, and Grayson Allen questionable, it's a wait and see situation for all players outside of Booker.

Suns G Devin Booker vs. Kings Projections: 28.5 points, 8 assists


Heat SG Tyler Herro vs. Magic

Injury Status: Out (foot/ankle)

Which Player Could Benefit: Bam Adebayo, Davion Mitchell

The former All-Star big man is one of two players on the Heat roster who can create his own shot — SF Andrew Wiggins being the other — and he’ll probably be expected to do just that while Herro is on the shelf for the next 2-3 months.

Last year, Bam's usage rose from 23.8% on the season to 27.5% with Herro and now-traded SF Jimmy Butler off the floor.

In Herro's place, Davion Mitchell and Norman Powell should soak up most of his minutes.

Heat C Bam Adebayo vs. Magic Projections: 19 points, 9 rebounds


Kings C Domantas Sabonis vs. Suns

Injury Status: Out (hamstring)

Which Player Could Benefit: DeMar DeRozan, Zach LaVine, Drew Eubanks

DeRozan never met a shot he didn’t like, and without the ball-depedent Sabonis sucking up the touches, he’ll have all the looks he wants. With De'Aaron Fox (now on Spurs) and Sabonis off the floor in 2024-25, DeRozan's usage jumped to 28.5% vs. 25% on the season.

Zach LaVine should also see a tick up in shots. We'll also see Drew Eubanks start at center in all likelihood, but it's hard to know what we'll get out of Eubanks on his new squad.

Kings SF DeMar DeRozan vs. Suns Projections via PrizePicks: 22.5 points, 4 rebounds


Bulls SG Coby White vs. Pistons

Injury Status: Out (calf)

Which Player Could Benefit: Ayo Dosunmu, Josh Giddey

White is set to miss the first few weeks of the season. The University of Illinois product averaged 15.2 points in the preseason, and could be a major factor if he’s in the starting lineup at SG as expected.

Additionally, PG Josh Giddey may also see more action as a shooter and distributor, while C Nikola Vuceevic may also see a tick up in usage.

Bulls SG Ayo Dosunmu vs. Pistons Projections: 12.5 points, 2.5 assists


Full NBA Injury Report for Wednesday, Oct. 22

Here are the full injury designations for Wednesday's game as of 2 p.m. EST today.

Out

Cavs PG Darius Garland

Cavs SG Max Strus

Knicks SG Josh Hart

Knicks C Mitchell Robinson

Hornets PF Grant Williams

Heat SG Tyler Herro

Magic C Moritz Wagner

76ers SF Paul George

Celtics F Jayson Tatum

Pistons FJaden Ivey

Bulls SG Coby White

Pelicans PG Dejounte Murray

Grizzlies G Vince Williams Jr.

Grizzlies G Ty Jerome

Grizzlies SF Scotty Pippen Jr.

Grizzlies PF Brandon Clarke

Grizzlies C Zach Edey

Spurs PG De'Aaron Fox

Spurs SF Jeremy Sochan

Mavericks C Daniel Gafford

Mavericks PG Kyrie Irving

Kings C Domantas Sabonis

Kings G Keegan Murray

Suns G Jalen Green

Blazers PG Damian Lillard

Blazers PF Robert Williams

Questionable

Cavs PF De'Andre Hunter

Knicks C Karl-Anthony Towns

Heat SF Kel'el Ware

Magic SG Jalen Suggs

Jazz SF Ace Bailey

Timberwolves SG Anthony Edwards

Likely to Play

Knicks SF OG Anunoby

Pistons SF Caris LeVert

Suns SG Grayson Allen


Be sure to keep tracking all of the NBA injury news today before locking in your Lineups on PrizePicks or NBA DFS.

Visit PrizePicks Playbook for the latest NBA injury analysis, plus picks, predictions, and analysis that may just take your PrizePicks NBA Lineups next level.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

about the author

Alan Goldsher has written about sports for Sports Illustrated, ESPN, Apple, Playboy, NFL.com, and NBA.com, and he’s the creator of the Chicago Sports Stuff Substack. He’s the bestselling author of 15 books, and the founder/CEO of Gold Note Records. Alan lives in Chicago, where he writes, makes music, and consumes and creates way too much Bears content.

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