Week 7 of the 2026 college football season features a major SEC showdown as the #13 Missouri Tigers travel to Oxford to take on the #9 Ole Miss Rebels.
Missouri enters Saturday's matchup at 5-1 after consecutive SEC victories over Florida and Texas A&M. Ole Miss is 4-1 and coming off a dominant 52-17 road win over Vanderbilt, setting up a battle between two teams looking to strengthen their College Football Playoff resumes..
Can Missouri's explosive ground game carry the Tigers to another statement victory, or will QB Trinidad Chambliss and the Rebels' high-powered offense protect home field?
Missouri vs. Ole Miss kicks off at 3:30 p.m. ET on the SEC Network from Vaught-Hemingway Stadium in Oxford, Miss. Ole Miss enters the matchup as a 4.5-point favorite, with the total set at 58.5.
Below, we'll break down our Missouri vs. Ole Miss prediction and picks for Saturday's game, including the winner, spread, over/under, and key player projections for PrizePicks.
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#13 Missouri vs. #9 Ole Miss Prediction, Spread, Over/Under – Saturday, October 17
Ole Miss enters Saturday's game as a 4.5-point favorite against Missouri, returning a 1.47x payout if it wins.
Here are the full payouts for Missouri vs. Ole Miss on PrizePicks.
Team Picks data is live at the time of writing and is subject to change.
Make your Missouri vs. Ole Miss prediction on the spread or over/under on PrizePicks.
Missouri has struggled to generate consistent offensive success at times, but the Tigers' ground game gives them a path to keeping this matchup close. RB Jamal Roberts leads the SEC and ranks second nationally with 828 rushing yards, while Ole Miss has allowed 176.4 rushing yards per game.
Missouri's ability to control the line of scrimmage, run the clock, and keep this high-powered Ole Miss offense on the sideline may be paramount to keeping this one competitive.
The Tigers are no slouch on the other side of the ball, ranking fifth in adjusted defensive EPA/play and allowing just 17.7 points per game. They've suppressed other dual-threat QBs in Florida (Aaron Philo) and Mississippi State (Kamario Taylor), but Chambliss and Ole Miss are likely the toughest challenge to date.
Ole Miss has one of the country's most efficient offenses, ranking 14th in EPA/play (+0.274) and seventh in offensive success rate (54.4%). The Rebels are averaging 38.8 PPG and have scored at least 32 points in all five games this season.
With Chambliss throwing for 1,435 yards and 11 TDs, Ole Miss has the firepower to turn this into a shootout, which wouldn't bode well for Mizzou.
The problem for Ole Miss is on the other side of the ball. Its defense has struggled mightily to match that offensive production, ranking 99th in EPA/play and allowing 28.0 PPG. The Rebels have been equally as vulnerable to the run as the pass, which could give QB Austin Simmons and this Tigers offense an opening.
Missouri vs. Ole Miss Prediction on Spread – 10/17/26
Here are the key stats and predictions behind our Missouri vs. Ole Miss pick against the spread for Saturday, October 17.
Unless otherwise noted, data used in this article is from College Football Ratings, Game on Paper, or PFF.
- Missouri's defense is miles ahead of that of Ole Miss. The Tigers sit 14th nationally in success rate allowed (37.7%), while the Rebels rank 92nd (45.7%).
- Roberts has also posted consecutive 200-yard games and has a direct path to continuing that success today. If he does, it likely means Ole Miss is losing the time-of-possession battle.
- Missouri's defense could force Ole Miss to become more one-dimensional. The Tigers rank eighth in rushing defense, allowing only 78.3 YPG and 2.44 yards per carry.
- When Chambliss does take to the air, he'll be throwing into the teeth of a defense that ranks 18th in passing success rate (37.2%).
- The Tigers also do a phenomenal job of generating havoc, sitting fourth in the country in pressure clip at 21.7%. Missouri has the personnel to put Chambliss in tough spots routinely.
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Missouri vs. Ole Miss Picks, Player Stats for PrizePicks: 10/17/26
Here are two Missouri vs. Ole Miss projections to consider for Saturday's SEC showdown. Today's college football picks for PrizePicks focus on Missouri RB Jamal Roberts and Ole Miss QB Trinidad Chambliss.
Missouri RB Jamal Roberts vs. Ole Miss: 118.5 Rush Yards
- Roberts has been one of the most productive RBs in college football, averaging 138 YPG and 5.6 YPC.
- The Missouri back has been nearly unstoppable over the last two weeks, rushing for 433 yards and 5 TDs against Florida and Texas A&M. He followed a 211-yard outing against Florida with a career-high 222 yards against the Aggies.
- Roberts has 673 yards after contact, the most in the FBS and 102 more than the next-highest total. He's averaging 4.4 yards after contact per attempt.
- One thing you know you are getting with Roberts is a consistent workload. He averages a whopping 24.5 carries per contest.
Add Jamal Roberts + Missouri to win to your PrizePicks lineup now.
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Ole Miss QB Trinidad Chambliss vs. Missouri: 292.5 Pass Yards
- Chambliss has cleared this projection in three of his five starts (60%) this season.
- The Ole Miss QB has demonstrated a high ceiling, throwing for 363 yards against LSU and 336 against Florida.
- Ole Miss averages 300.6 passing YPG and can generate explosive plays with the very best teams in the country.
- While Missouri certainly presents a challenge defensively, a low-spread and high-total game script could keep Chambliss throwing early and often. It's also a window for a potential Heisman moment.
Add Trinidad Chambliss + Ole Miss to cover the spread to your PrizePicks lineup now.
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SEC football takes center stage Saturday afternoon as the Tigers travel to Oxford to face the Rebels. Can Roberts continue his historic run and help Missouri pull off a road upset, or will Chambliss and the Ole Miss offense prove too much for the Tigers' defense?
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