In the first college basketball game of the NCAA Tournament on Sunday, the No. 7 seed Miami Hurricanes (26-8) take on No. 2 seed Purdue Boilermakers (28-8) in the West Region of the bracket on CBS at 12:10 p.m. ET.
The winner between Miami (FL) vs. Purdue will advance to the Round of 16 to take on Texas.
Purdue enters a 7.5-point favorite vs. Miami (FL), according to PrizePicks Team Picks. Can the Miami Hurricanes pull off an upset in the second round of the NCAA Tournament?
Below, we’ll break down our Miami vs.Purdue prediction and pick on the spread for Sunday’s NCAA Tournament game in the Round of 32. Make your college basketball picks on PrizePicks and earn real money if you’re right, including on game winners, spreads, and totals!
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Miami vs. Purdue Prediction, Spread, Over/Under
To earn a date with Purdue on Sunday, Miami took down the No. 10 Missouri Tigers, 80-66, in the first round, outscoring the Tigers 53-40 in the second half. The Hurricanes are 7-3 outright and against the spread (ATS) over the last 10 contests.
Led by experienced G Braden Smith (14.3 PPG, 9.0 APG), Purdue had no issues putting away the No. 15 Queens University Royals, 104-71, in the first round of the NCAA Tournament.
The Boilermakers are currently on a five-game winning streak, and they’ve gone 3-1 ATS in their last four matchups, including the Big Ten Tournament.
Miami vs. Purdue Spread, Over/Under for NCAA Tournament Game
The Purdue Boilermakers are favored by 7.5 points on the spread in this second-round game, returning a 1.29x payout on PrizePicks Team Picks if they win outright.
The Miami are underdogs with a 3.57x payout for college basketball picks on PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Purdue -7.5 (1.88x payout)
- Over/Under: 147.5 (1.88x payout on over)
- Game Winner Payout: Miami 3.57x | Purdue 1.29x
Team Picks data is live at the time of writing and is subject to change.
Miami vs. Purdue Prediction on Spread for NCAA Tournament – March 22, 2026
Here are the key stats to know before locking in your Miami vs. Purdue prediction on the spread for the 2026 NCAA Tournament second-round game on Sunday, March 22, on PrizePicks.
- In their seven games against ranked opponents this season, the Miami Hurricanes have gone 3-4 ATS.
- Out of 365 Division I schools, Miami ranks 321st in free-throw percentage (68.1%).
- The Hurricanes converted only 17 of their 29 free-throw attempts (58.6%) in their win over the Missouri Tigers on Friday.
- Purdue is an extremely efficient squad, ranking first in adjusted offensive efficiency (133.5), 10th in effective field-goal percentage (58.1%), and 12th in three-point percentage (38.5%).
- Purdue is on a five-game win streak after its first-round win vs. Queens — including a 80-72 win vs. Michigan to win the Big Ten championship.
- Although Miami is 51st in the nation in steals per game (7.9), the Boilermakers have the 15th-lowest offensive turnover rate (13.6%).
- Purdue is 6-4 against the spread vs. ranked opponents, while Miami is 3-4 ATS in the same sample.
- At the end of the regular season, the Boilermakers were ranked No. 8, and Miami was No. 25 in the AP Top 25 Poll.
- Although it’s a small sample, Miami is 1-2 ATS in the three games where they’ve been underdogs of 7.5 points or more.
- Miami is at a rest disadvantage on a quick turnaround after Friday night's win over Missouri, a back-and-forth game which finished after midnight (ET) on Thursday night.
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Make Your Miami (FL) vs. Purdue Prediction on PrizePicks
There aren’t many teams better than Purdue on the offensive end of the court in the 2026 NCAA Tournament. If the Miami Hurricanes want to pull off the upset, they’ll need to make their free throws and prevent the Boilermakers from generating open shots.
You can make your Miami vs. Purdue prediction on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct.
On Team Picks, you can make predictions on winners, spreads, and over/unders, now available in 35 states.
Stick around with the Playbook for continued college basketball predictions, picks, and news through the NCAA Tournament.
