Manchester United hopes to effectively secure a place in next season’s Champions League on Monday, April 27 when they host Brentford in a Premier League fixture at 3:00 p.m. on USA Network.
Manchester United are favored to win at Old Trafford, returning a 1.85x payout if they claim victory, according to PrizePicks Team Picks.
A win would see the Red Devils move 11 points clear of sixth-placed Brighton & Hove Albion with a top-five finish all but secured. Brentford needs all three points to jump into sixth place and move within seven points of the top five with four matches to go.
Below, we’ll break down our Manchester United vs. Brentford prediction and picks for Monday afternoon’s Premier League match, including the spread, total goals, and key player picks for PrizePicks.
Make your picks for Manchester United vs. Brentford on PrizePicks now.
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Manchester United vs. Brentford Prediction, Picks for Premier League – Monday, April 27
The Red Devils know how vital a Champions League spot is to their finances, and they need just a few more points to clinch a spot. With Liverpool coming up next weekend, they’ll aim to pick up a result on Monday.
No club in the Premier League has earned more of them since Michael Carrick’s appointment as manager, and he navigated a selection crisis last weekend with a 1-0 win over Chelsea at Stamford Bridge.
He may have an easier go of selecting his lineup this week with CB Harry Maguire back from suspension. He'll line up alongside the young CB Ayden Heaven, who impressed against the Blues.
Fellow CBs Leny Yoro and Matthijs de Ligt are still injured, while CB Lisandro Martinez is suspended. However, LB Patrick Dorgu appears to be ready for a surprise return to the squad after being out since January with a hamstring injury.
The biggest question will be in attack. ST Benjamin Sesko has been much more impactful off the bench, which may see Carrick drop him for RW Amad Diallo. That would move RW Bryan Mbeumo into the striker role, where he’s deputized many times this season.
Bruno Fernandes will pull the strings as always. He’s now just 3 assists away from setting the single-season Premier League record and is a key reason why Sesko, Mbeumo, and FW Matheus Cunha all rank in the top 10 in total shots on target, per Opta.
Brentford won the reverse fixture back in September before GK Senne Lammens took over for the Red Devils. Their 3-1 victory came despite Manchester United holding a slight 2.08-2.02 expected goals advantage, with the Bees ripping through the 3-4-2-1 setup under former manager Ruben Amorim.
The Bees have drawn six straight matches in all competitions and are seeing their hopes of participating in Europe next season fading away. ST Igor Thiago has had a brilliant season with 21 goals in 32 Premier League starts, but he’s scored just three open-play goals in his last 12 outings.
They’ll be without CM Jordan Henderson, CM Fabio Carvalho, and LB Rico Henry. CM Vitaly Janelt also misses out for the Bees.
Brentford has been involved in three scoreless draws in their last five league fixtures. A point on Monday would move them into seventh and a UEFA Conference League spot for next season but would likely end their hopes of making the Champions League.
Manchester United vs. Brentford Spread, Total Goals, Payouts - Monday, April 27
Manchester United enters Monday’s game as home favorites, returning a 1.85x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Manchester United vs. Brentford match on PrizePicks.
- Winner Payout: Manchester United – 1.85x | Tie – 3.44x | Brentford – 3.57x
- Spread: Manchester United -1.5 (3.12x payout)
- Total Goals: 3.5 (2.32x payout on Over)
- Both Teams to Score: Yes 1.51x | No 2.43x
Play the Manchester United vs. Brentford spread or total goals on PrizePicks Team Picks to earn real money—available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Manchester United vs. Brentford Prediction on Total Goals – Monday, April 27
Here are the key stats and trends behind our Manchester United vs. Brentford prediction on total goals for Monday, April 27.
Lock in your Manchester United vs. Brentford prediction on PrizePicks before the line moves.
- There has been an average of 3.16 goals scored in Manchester United’s six home Premier League fixtures since Carrick’s appointment.
- Three or fewer goals have been scored in four of those six matches.
- Brentford’s last two away fixtures in the Premier League have ended scoreless.
- There have been 3 or fewer goals scored in 10 of Brentford’s last 13 away fixtures in the Premier League.
- Nine of those 13 matches have seen no more than 2 goals scored.
- Brentford have been held without a goal in six of their last 12 away league outings.
- Manchester United allow only 3.70 shots on target per match, the third-fewest of any Premier League club.
- Brentford averages only 3.8 shots on target per away fixture in the league this season.
- Seven of Manchester United’s last nine Premier League matches have featured 3 or fewer goals.
Manchester United vs. Brentford Projected Lineups for Monday, April 27
Here are the projected Manchester United vs. Brentford lineups for today's Premier League match. Lineups are not official.
Manchester United Lineup vs. Brentford: Projected 4-2-3-1
- Goalkeeper: Senne Lammens
- Defense: Diogo Dalot, Harry Maguire, Ayden Heaven, Luke Shaw
- Midfield: Casemiro, Kobbie Mainoo, Bruno Fernandes
- Forwards: Bryan Mbeumo, Benjamin Sesko, Matheus Cunha
Brentford Lineup vs. Manchester United: Projected 4-2-3-1
- Goalkeeper: Caoimhin Kelleher
- Defense: Michael Kayode, Sepp van den Berg, Nathan Collins, Keane Lewis-Potter
- Midfield: Yehor Yarmoliuk, Mathias Jensen, Mikkel Damsgaard
- Forwards: Dango Ouattara, Igor Thiago, Kevin Schade
Manchester United vs. Brentford Player Picks, Stats for PrizePicks: 4/27/26
Here are two Manchester United vs. Brentford picks to target on players for Monday, April 27. Today’s Premier League picks for PrizePicks are headlined by Bruno Fernandes and Sepp van den Berg.
Manchester United MF Bruno Fernandes vs. Brentford: 0.5 Goals + Assists
- Bruno Fernandes has either scored or assisted in six consecutive matches for Manchester United.
- His 26 goal contributions are second only to Erling Haaland in the Premier League this season, with the Man City striker having 31.
- Bruno leads all players in the Premier League with 751 passes in the final third, per Opta.
- The Portuguese midfielder’s 18 assists are eight more than any other player and are two shy of tying the single-season Premier League record.
- His 109 chances created are 48 more than any other player in the Premier League.
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Brentford CB Sepp van den Berg vs. Manchester United: 45.5 Passes Attempted
- Sepp Berg has attempted fewer than 43 passes in four of his last five away starts for Brentford in the Premier League.
- In his five away league fixtures against sides that average more than 50% possession per match, Berg has averaged 35.8 passes per match.
- The defender had 35 passes in the reverse fixture on Sept. 9, 2025, when Brentford hosted Manchester United.
- Berg has averaged 41.6 passes per match in his last five away outings.
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Both teams need points for their European hopes, but Manchester United hold the better form at the moment. They’ve claimed 15 of 18 possible points from their last six home outings but will be leery of a Brentford side that hasn’t lost in their last six Premier League tilts.
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