Lynx vs. Fever Prediction, Spread, WNBA Picks for Tuesday, September 22

The Minnesota Lynx vs. Indiana Fever game is set to tip off at 8:00 p.m. ET on Tuesday, September 22, with the Fever entering as 1.5-point favorites on the spread and returning a 1.85x payout to win, via PrizePicks. 

After defeating the Sun on Sunday afternoon, the Lynx (32-10) can clinch the #1 seed for the second consecutive season with a win on Tuesday. Minnesota closes out the regular season with a home-and-home series against Indiana.

The Fever (27-15) took a significant hit to their home-court hopes with a loss to the Mystics on Sunday evening. Indiana now sits 1.5 games behind the Dream, who hold the #4 seed with one game remaining on their schedule.

Below, we'll break down our Lynx vs. Fever prediction and picks for Tuesday's WNBA game, including the spread, over/under, and key player picks for PrizePicks.

Make your Lynx vs. Fever picks on PrizePicks now!

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Lynx vs. Fever Prediction, Spread, Over/Under – Tuesday, September 22

With the WNBA Playoffs beginning on Sunday, the league's top eight teams are still jockeying for seeding as the regular season comes to a close on Thursday, September 24.

Tuesday's five-game slate will give us a clearer picture of what the first round will look like, as the Fever face a must-win situation if they want any chance at home-court advantage.

Indiana enters as slight favorites, though the availability of Lynx G Olivia Miles will likely play a significant role. The Rookie of the Year favorite is questionable with a calf injury, and with two games remaining, it will be interesting to see how HC Cheryl Reeve handles the situation.

Minnesota are the current WNBA Championship favorites on PrizePicks with a 2x payout, but losing Miles for any extended period would significantly shift the postseason landscape.

Tuesday's matchup could serve as a WNBA Finals preview, with elite guard play on both sides. Caitlin Clark and Kelsey Mitchell have cemented their place in WNBA history as the league's highest-scoring duo. Despite the loss, the two combined for 56 points in their first meeting against Minnesota this season.

Both Fever guards and Miles are considered MVP candidates, though PrizePicks has A'ja Wilson as the heavy favorite with a 1.02x payout to win the award in back-to-back seasons. If Miles can't go, the Lynx will lean heavily on F Napheesa Collier, who is slowly returning to form after missing 28 games to open the campaign.

The Fever will look to bounce back from one of their ugliest offensive performances of the season against a Minnesota defense that ranks fourth-lowest in defensive rating. Indiana was held to just 77 points in its most recent defeat despite leading the league in PPG and offensive rating this season.

Lynx vs. Fever Spread, Over/Under – Tuesday, September 22

The Fever enter Tuesday’s game as 1.5-point home favorites against the Lynx, returning a 1.85x payout if they win outright, via PrizePicks.

Here are the full payouts for the Lynx vs. Fever game on PrizePicks.

Make your Lynx vs. Fever prediction on the over/under on PrizePicks.

PrizePicks data is live at the time of writing and is subject to change.

Lynx vs. Fever Injury Report for Tuesday, September 22

Let’s dive into the full Lynx vs. Fever injury report for Tuesday, via WNBA.com.

Lynx Injury Report 

• F Anastasiia Olairi Kosu (foot) – OUT
• G Olivia Miles (calf) – Questionable

Fever Injury Report

• G Caitlin Clark (back) – Probable

Lynx vs. Fever Prediction on Over/Under – 9/22/26

Here are the key game stats and trends behind our Lynx vs. Fever prediction on Over/Under for Tuesday, September 22.

• These teams combined for 208 points in their first meeting back in August. Both rank in the top three in PPG and offensive rating.
• The Fever have been the top over team in the WNBA this season, with 61.9% of their games finishing above the total. Minnesota is tied for sixth, with 54.8% of its games going over.
• Indiana's elite offense has masked significant defensive struggles. The Fever are one of five teams allowing over 90.0 PPG and carry the fifth-highest defensive rating in the league at 109.4 heading into the final stretch, per WNBA.com.
• Minnesota is one of two teams to rank in the top four in both offensive and defensive rating, sitting third in PPG (91.3) and third in fewest PPG allowed (83.8).
• Indiana leads the league with a 120.9% true shooting percentage and ranks first in both FG% (49.1%) and 3-point percentage (39.4%). The Lynx are not far behind, ranking third in overall FG% (48.0%) and second in 3-point percentage (38.4%).

Lock in your Lynx vs. Fever prediction on PrizePicks now!

Lynx vs. Fever Picks, Player Stats for PrizePicks – 9/22/26

Here are the top Lynx vs. Fever picks to target on PrizePicks for Tuesday, September 22. Today’s WNBA picks for PrizePicks include Napheesa Collier and Caitlin Clark.

Lynx F Napheesa Collier vs. Fever: 30.5 Pts + Rebs + Asts

• Collier could play her first game without Miles this season, likely making her the team's primary scoring option by default. The former DPOY is averaging the third-most field goal attempts per game (13.4) despite playing in just 14 games this season.
• The 29-year-old is averaging 28.0 combined points, rebounds, and assists per game since returning from injury but has surpassed 30.5 in just five of those 14 games.
• Sunday's win over the Sun marked the sixth straight game Collier finished under 30.5 PRA, a run stretching back to August 12 against the Fire.
• If Miles plays on Tuesday, Collier's volume should stay roughly the same; the rookie guard leads the team in points, assists, and field goal attempts per game.

Add Napheesa Collier to your PrizePicks lineup now.

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Fever G Caitlin Clark vs. Lynx: 30.5 Pts + Asts

• Clark's 25-point outing on Sunday marked her fifth straight game with 20 or more points. The 24-year-old has scored 20 or more in 13 of the 15 games since the All-Star break.
• One of the two games she finished under 20 points in that stretch came against the Lynx back in August: 19 points and 10 assists on 8-of-18 shooting.
• Clark's 8.45 assists per game rank second in the league, just 0.06 behind Alyssa Thomas. She had just 5 assists in her most recent game but recorded double-digit assists in three straight games before that.
• Over her last four games, Clark is averaging a whopping 31.0 points and 10.3 assists per game.

Add Caitlin Clark to your PrizePicks lineup now.

Make Lynx vs. Fever Picks on PrizePicks

With both teams still fighting for seeding, expect a playoff-like atmosphere when the Fever host the Lynx on Tuesday evening. The title favorites will look to upset Indiana on its home floor, but may have to do it without Olivia Miles.

Don’t wait until tip-off — make your Lynx vs. Fever picks on PrizePicks now and earn real money if you’re right.

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