Knicks vs. Cavaliers Prediction, Spread, Game 4 Picks – Monday, May 25

Game 4 of the Eastern Conference Finals between the New York Knicks and Cleveland Cavaliers tips off at 8:00 p.m. ET on Monday, May 25, televised by ESPN. According to PrizePicks Team Picks, New York is a 2.5-point favorite on the spread.

The Knicks are one win away from their first NBA Finals appearance since 1999. They have won a franchise record 10 consecutive playoff games since trailing the Hawks 2-1 in the first round. The Cavaliers, who came back from a 2-0 deficit in the second round vs. the Pistons, have a steep mountain to climb with a 3-0 deficit.

Below, we’ll break down our Knicks vs. Cavaliers prediction and picks for Monday’s NBA game, including the spread for PrizePicks.

Make your Knicks vs. Cavaliers picks on PrizePicks for Game 4 of the Eastern Conference Finals.

{{nba_offer_banner="/style-system/ui-components-playbook"}}

Knicks vs. Cavaliers Prediction, Spread, Over/Under for Game 4 – Monday, May 25

Since trailing 2-1 vs. the Hawks, the Knicks have won a franchise-record 10 straight postseason games, all by double digits. Through 13 games, they have the highest point differential in postseason history (+234). A win on Monday would be the second straight four-game sweep for the Knicks. They entered the 2026 playoffs with two four-game sweeps in franchise history. 

Knicks G Jalen Brunson is averaging 27.8 points per game in the postseason, ranking as the third-highest total behind Shai Gilgeous-Alexander and Cade Cunningham. In the first three games vs. the Cavs, he's totaled 87 points and 26 assists, shooting 50.0% from the field.

According to PrizePicks Team Picks, Brunson is the clear favorite to win the Eastern Conference Finals MVP with a 1.01x payout.

The Cavaliers never led in Game 3 and have been outscored by 62 points since holding a 22-point lead in Game 1. Cleveland has shot 43% from the field and 63.4% at the line from that point. Plus, it has not held a lead since the 9:04 mark in the second quarter of Game 2.   

After winning their first six home postseason games, the Cavaliers have lost the last two at the Rocket Arena, losing by 21 to the Pistons in Game 6 of the semifinals and 13 to the Knicks on Saturday night.

Knicks vs. Cavaliers Spread, Over/Under for Game 4 – Monday, May 25

The Knicks enter Monday’s game as 2.5-point road favorites against the Cavaliers, returning a 1.66x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for Knicks vs. Cavaliers on PrizePicks

• Spread: New York Knicks -2.5 (1.85x payout)
• Over/Under: 219.5 (1.92x)
• Game Winner Payout: Knicks 1.66x | Cavaliers 2.12x

Make your Knicks vs. Cavaliers prediction on the spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

New York Knicks vs. Cleveland Cavaliers Timeline

Here is the full Knicks vs. Cavaliers timeline, including the playoff series game-by-game and recent matchup history.

All-Time: Knicks, 138-112

Regular Season: Knicks, 2-1

Postseason: Knicks, 3-0

Knicks vs. Cavaliers Eastern Conference Finals Timeline, Schedule

• Game 1: Knicks, 115-104, OT
• Game 2: Knicks, 109-93
• Game 3: Knicks, 121-108
• Game 4: Monday, May 25, 8:00 p.m. in Cleveland
• Game 5-7: if necessary

{{nba_offer_banner="/style-system/ui-components-playbook"}}

Knicks vs. Cavaliers Prediction on Spread for Game 4 – 5/25/26

Here are the key stats and trends behind our Knicks vs. Cavaliers prediction on the spread for Monday, May 25.

Lock in your Knicks vs. Cavaliers prediction on PrizePicks before Game 4 tips off.

• The Knicks are the 10th team in NBA history to win 10 straight games in a single postseason. Five of the previous nine teams went on to win the NBA title. 
• New York is 54-42 ATS this season (56.3%). The 54 covers are the second-most in the NBA, behind the Spurs. New York covered in four of six games against the Hawks in the first round, three of four vs. the 76ers, and all three games vs. the Cavs. 
• While the Knicks have been among the best cover teams this season, they have not been that on the road, covering in only 12 of 31 games as the road favorite. They are 3-1 as a road favorite in the postseason. 
• New York finished the season 10th in scoring (116.5 PPG), fourth in offensive rating (118.7), and ninth in eFG% (55.7%). Through 13 postseason games, the Knicks lead all teams in eFG% (59.3%) and FG% (51.7%), while sitting second in offensive rating (122.9) and points per game (119.2).
• Cleveland is 40-59 (40.4%) this season against the spread, the worst cover percentage in the NBA. It's only covered in seven of the 17 postseason games, but five of those covers have been at home. 
• The Cavs have been swept in a four-game series three previous times: 2018 NBA Finals to Warriors, 2007 NBA Finals to Spurs, and 1993 Eastern Conference semifinals to Michael Jordan and the Bulls.
• Cleveland had one of the best offenses this season, finishing the regular season fourth in scoring (119.5) and sixth in offensive rating (118.3). In the postseason, they are fifth in scoring (108.8) and fifth in eFG% (53.5%).

Knicks vs. Cavaliers Picks, Stats for PrizePicks: 5/25/26

Here are the top Knicks vs. Cavaliers picks to target on PrizePicks for Monday, May 25. Today’s NBA picks for PrizePicks include G Mikal Bridges and C Karl-Anthony Towns

Get a Payout Boost every night of the NBA Playoffs on PrizePicks.

Knicks G Mikal Bridges vs. Cavaliers: 21.5 Pts + Rebs + Asts

• Knicks G Mikal Bridges has hit his PRA projection in eight consecutive games.
• In the last eight games, Bridges has played an average of 34.1 minutes per game, recording 36+ minutes in five contests. In the seven games prior, Bridges averaged 28.1 minutes per game. 
• The Villanova product has been on a heater, averaging 18.3 points and 4.7 rebounds per game in the series.
• He has scored 17+ points in seven of the last eight games, dating back to the Hawks series.  

Add Mikal Bridges to your PrizePicks Lineup now.

Knicks C Karl-Anthony Towns vs. Cavaliers: 5 Assists

• Knicks C Karl-Anthony Towns has hit his assists projection in 10 of the past 11 games. 
• KAT has recorded 5+ assists in nine of the last 10 games, averaging 6.9 per game. 
• The Kentucky product averaged 6.5 assists in the final four games of the regular season. Dating back to April 1, he’s averaging 5.9 assists per game over 18 matchups. 
• In the three regular-season games against the Cavs this season, KAT had 5 total assists. He has 13 over three games of the ECF. 

Add Karl-Anthony Towns to your PrizePicks Lineup now.

{{nba_offer_banner="/style-system/ui-components-playbook"}}

NBA Playoffs Live Picks: Knicks vs. Cavaliers on PrizePicks for Game 4

Here are some in-game angles to target for your Knicks vs. Cavaliers live picks in today’s game. 

Every live NBA Lineup on PrizePicks during the NBA Playoffs enters you to win a trip to the NBA Finals — paid by PrizePicks. Make your live NBA Playoffs picks on PrizePicks.

• In 80 career postseason games, Brunson is averaging 25.8 points, 3.7 rebounds, and 5.6 assists per game. 
• The Cavs, despite their collapse in Game 1, are the highest-scoring team in the second half of games this season, posting 60.1 PPG. 
• New York can take advantage in the second quarter, as Cleveland averages only 27.7 points per second quarter (27th). However, the Cavs have won the second quarter in two of the three ECF games. 
• Including the postseason, the Knicks have the best fourth-quarter scoring margin in the NBA (+3.0). They’ve outscored the Cavs by 19 in the fourth quarter of this series.

Make Knicks vs. Cavaliers Picks on PrizePicks

Will the Cavaliers stay alive with their season on the line at home? Or will the Knicks win their first Eastern Conference crown since 1999 with their 11th straight postseason game?

Don’t wait until lock — make your Knicks vs. Cavaliers picks on PrizePicks now and earn real money if you’re right.

With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

Stay locked in on Playbook for daily NBA predictions, picks, and news every day all the way through the 2026 NBA Finals.