Jonathan Taylor Stats, Pick for MNF: Colts Stud Eyes Rushing Title

December 22, 2025

NFL
AP Photo/John Amis

Week 16 in the NFL wraps with the San Francisco 49ers (10-4) and the Indianapolis Colts (8-6) throwing down on Monday Night Football. Kickoff is set for 8:15 p.m. ET on both ABC and ESPN. 

It’s a tale of two seasons for the Colts. Through their first ten games, they were 8-2, holding the first seed in the AFC standings.Since then, they've dropped four in a row, they're on the outside looking in at the postseason, and their QB Daniel Jones is out for the season after suffering a torn Achilles tendon

And then there's Jonathan Taylor

After a phenomenal start to the year, the Colts RB shows signs of regression — he went from averaging 113.9 rushing yards per game in Weeks 1-10 to 76.0 in Weeks 12-15.

Here, we’ll drop our top Jonathan Taylor stats and pick for Indy's Monday night meet-up with the Niners. PrizePicks is the best place to make your MNF picks tonight, including on Taylor's rushing yards.

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Jonathan Taylor Stats, Pick for MNF

Below is our analysis for Jonathan Taylor vs. 49ers in the Week 16 Monday Night Football contest. Pick players, predict More or Less on their projected stats, and cash out with PrizePicks if you're right on MNF or any other NFL game.

Colts RB Jonathan Taylor Stat Projection vs. 49ers: 99.5 Pass Yards

  • Taylor was locked in at the start of the season. From Weeks 1-10, he led the league with 1,094 yards, 15 rushing TDs, and 6.3 yards per carry.
  • Since Week 12, the Colts’ RB is sixth in rushing yards (304), with 1 rushing TD, averaging 3.7 yards per carry.
  • Each of the Colts’ opponents from Weeks 12-15 ranks in the top ten in rushing success rate.
  • San Francisco ranks 31st in rush success rate (46.9%).
  • According to NFL Pro, the shifty Wisconsin product ranks eighth in rushing success (44.5%).
  • The 49ers give up 5.4 yards per carry in their last three games, ranking 29th.
  • San Fran allowed 136 rushing yards to the Titans in their 37-24 Week 15 win. Tennessee ranks 30th in rushing yards per game (88.6).
  • Since star 49ers LB Fred Warner's went out for the season, the run defense has shown a decline. In the six games Warner played, San Francisco allowed 82.2 yards per game, but in the eight games since his season-ending ankle injury, they allow 115.8. 
  • The former second-round pick has seen plenty of action recently, with 20+ carries in three straight games.

More Jonathan Taylor Projections vs. 49ers Tonight

Here are some other top Jonathan Taylor projections vs. 49ers on Monday Night Football, via PrizePicks.

  • 23 Rush Attempts 
  • 19.5 Receiving Yards
  • 120 Rush+Rec Yards
  • 0.5 Rush+Rec TDs (Goblin)
  • 17.5 Yards on Longest Rush
  • 10.5 Yards on Longest Reception
  • 19.5 Fantasy Score
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Make 49ers vs. Colts Monday Night Football Picks on PrizePicks

The Colts are trying to snap their four-game losing streak and get back into playoff contention, thus a big night from RB Jonathan Taylor is crucial.

The MNF 49ers vs. Colts matchup presents a large variety of Monday Night Football picks to choose from — including Taylor’s rushing yards.

Get in on the MNF action with PrizePicks. Just pick More or Less on projected player stats and win real money if you’re right.

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John is a graduate from Quinnipiac University with a Master's Degree in Sports Journalism. With almost 15 years working in radio, TV and blogs, it includes stops at ESPN, NBC Sports, and Audacy. Along with being an avid sports fan, he is into fitness and cooking.