Grizzlies vs. Spurs Prediction, Picks: De'Aaron Fox Is Healthy and Balling Out

De’Aaron Fox dribbles a basketball in an NBA game.
AP Photo/Eric Gay

The San Antonio Spurs (13-6) can pull into a first-place tie with the Houston Rockets atop the Southwest division with a victory tonight.

The Spurs welcome the Memphis Grizzlies (9-12) in a division battle on Tuesday as San Antonio returns home following a 2-2 road trip. 

C Victor Wembanyama has missed the last seven games for the Spurs with a calf strain. San Antonio hasn’t skipped a beat without the top pick of the 2023 draft, going 5-2 in this stretch. 

The Grizzlies are looking to wrap up their road swing a perfect 4-0 with a win tonight after beating the Pelicans, Clippers, and Kings.

Let’s look at the Grizzlies vs. Spurs prediction and picks for Tuesday night’s battle at Frost Bank Center, tipping off at 8:00 p.m. ET.

Grizzlies vs. Spurs Prediction, Preview for 12/2/25

San Antonio has shined at home, posting an impressive 8-2 record. The Spurs enter this matchup as 5.5-point favorites, returning a 1.42x payout on PrizePicks Team Picks if they win outright.


The Grizzlies are road underdogs with a 2.7x payout if they win, via PrizePicks Team Picks.

  • Spread: San Antonio Spurs -5.5
  • Total: 230.5
  • Game Winner Payout: Grizzlies 2.7x | Spurs 1.42x

(Data via PrizePicks Team Picks)


Here are some stats to know to get you set for Grizzlies vs. Spurs tonight, including insights on our Grizzlies vs. Spurs prediction.

  • The Spurs closed out their trip on Sunday with a 125-112 loss at Minnesota. The Wolves outscored San Antonio, 36-19 in the fourth quarter.
  • It’s amazing what San Antonio has accomplished considering Wembanyama and last season’s Rookie of the Year Stephon Castle have been sidelined. Castle has missed the last six games with a hip injury.
  • The Spurs defeated the Grizzlies, 111-101 on November 18 as 6-point favorites. Memphis was held to 40% shooting from the floor and attempted only 9 free throws.
  • The Grizzlies suffered through a 1-9 slump from Halloween through November 18, but have won five of their last six games.
  • Memphis trailed in the fourth quarter in each of its last three victories. Grizzlies C Zach Edey shot an incredible 16-of-20 from the floor and led the team with 32 points and 17 rebounds. 
  • Since starting 1-6 on the road, the Grizzlies have won four consecutive games away from FedEx Forum. 
  • Grizzlies G Ja Morant has missed the last seven games with a calf injury and is out tonight.

Memphis Grizzlies

  • The Grizzlies have finished Under the total in seven of the last nine games. Six of the past seven road contests have gone Under.
  • Memphis sits 26th in the NBA in 3-point shooting at 33.7%. In the previous five games, the Grizzlies have shot 37.4% from downtown, ranking ninth in this stretch.
  • This team has nearly identical shooting numbers at home and on the road. Memphis is shooting 44.2% at home and 44.3% on the road and is averaging 90.9 shots per game.

San Antonio Spurs 

  • The Spurs have performed better from 3-point range at home, hitting 38.7% compared to 32.1% on the road.
  • San Antonio owns a home net rating of 6.9, eighth in the league.
  • In 10 home games, the Spurs have covered the point spread seven times.

Grizzlies vs. Spurs Picks & NBA DFS

Here are three top Grizzlies vs. Spurs picks to target on Tuesday. Key PrizePicks player projections are headlined by San Antonio G De’Aaron Fox, Memphis F/C Jaren Jackson Jr., and Spurs F Harrison Barnes.

Spurs G De’Aaron Fox vs. Grizzlies Projection: 24.5 Points

  • Fox missed the first eight games due to a right hamstring injury. Since his return, the former Kentucky standout has averaged 24.1 points per game.
  • In six of the last seven games, Fox has topped the 25-point mark, including a 25-point effort in Sunday’s loss at Minnesota.
  • The former Sacramento King is shooting a scorching 42.1% from 3-point range at home. He has knocked down at least two 3-pointers in five of six games at Frost Bank Center. 
  • In the previous matchup with Memphis on November 18, Fox scored 26 points on 10-of-20 shooting from the floor.

Grizzlies F/C Jaren Jackson Jr. vs. Spurs Projection: 27.5 Pts+Rebs

  • Jackson leads the Grizzlies in scoring at 18.3 ppg, which is nearly a 4-point decrease from last season’s average.
  • In the first two games of this road swing, Jackson posted 27 points at New Orleans and 24 points against the Clippers. He was held to 13 points in Sunday’s win at Sacramento.
  • The nimble big is putting up nearly 20 ppg on the road, although his field goal percentage sits at 44.7%. 
  • In 10 of his last 12 outings, Jackson has been limited to less than 28 points and rebounds.
  • In the 10-point defeat at San Antonio, Jackson scored 18 points and pulled down 6 boards. It marked the only game that Jackson has not attempted a free throw.

Spurs F Harrison Barnes vs. Grizzlies Projection: 13.5 Points

  • For the 13th straight season, Barnes is averaging double-digits in scoring. He is currently putting up 12.4 ppg in 19 contests.
  • Barnes struggled at Minnesota on Sunday, getting held to 5 points on 2-of-9 shooting.
  • In the last four games, Barnes has been limited to 13 or fewer points.
  • The former University of North Carolina star is averaging 19.6 ppg in his previous three home contests, including a 23-point effort against Memphis on November 18.
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The Grizzlies look to close out their road trip a perfect 4-0 against a Spurs squad that has been red-hot at home this season.

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about the author

Kevin has spent the last 15 years in the sports gambling space. He covered all major sports at VegasInsider both as a writer and handicapper from 2009 until 2024. He has also covered college basketball and MLB for the Action Network.

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