Everyone has played at least one college football game by now, and Week 2’s main slate begins with the #7 Miami Hurricanes hosting Florida A&M on Thursday in Miami Gardens, FL. The Hurricanes enter as a 57.5-point favorite on the spread, via PrizePicks.
The Canes, who lost in the CFP National Championship Game last year, opened up with a 45-6 shellacking of Stanford on the road in the Bay Area last week. Florida A&M has played twice, starting the year with a win over Albany State before losing to SC State last week at home.
Below, we’ll break down our Florida A&M vs. Miami prediction and picks for Thursday’s college football game, including the game winner, spread, and over/under for PrizePicks.
Make your Florida A&M vs. Miami picks on PrizePicks for Thursday’s game.
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Florida A&M vs. #7 Miami Prediction, Spread, Over/Under – Thursday, September 10
Miami entered 2026 with high expectations after losing to Indiana by 6 points in the national title game, and the program backed the hype up in Week 1.
Heisman Trophy candidates QB Darian Mensah and WR Malachi Toney led the way, as Mensah’s first game since transferring from Duke ended with 5 TD passes and Toney set a school record with 234 receiving yards. Toney was on the receiving end of three of those TDs, including each of the first two drives.
Mensah is now the favorite to win the Heisman at PrizePicks Team Picks, returning a 5.26x payout, while Toney has the ninth-shortest price at an 11.11x payout.
Per Pro Football Focus, Mensah posted a 9.7% big-time throw rate without recording a turnover-worthy play, while Toney averaged 7.50 yards per route run. The Canes finished 2025 with the fourth-highest average EPA per play at +0.52, so the big plays in Week 1 should come as no surprise.
Miami’s 428 passing yards overall were the fifth-most of any team last week and more than any game they played last season.
The one area Miami did not do well in vs. Stanford, which is where Florida A&M will need to concentrate, is the run game. Miami was held to 121 rushing yards and 3.8 yards per try vs. Stanford and faces a Rattlers defense that did hold Albany State to 3 total rushing yards in Week 1.
They didn't have the same success last week, though, allowing 292 rushing yards in a loss to South Carolina State.
Florida A&M vs. Miami Spread, Over/Under – Thursday, September 10
Miami enters Thursday’s game as a 57.5-point favorite at Hard Rock Stadium, according to PrizePicks.
Here are the full payouts for Florida A&M vs. Miami on PrizePicks.
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Team Picks data is live at the time of writing and is subject to change.
Florida A&M vs. Miami Prediction on Spread – 9/10/26
Here are the key stats and trends behind our Florida A&M vs. Miami prediction on the spread for Thursday, September 10.
- After earning 11 covers against the spread last year (11-5), which was the second-most behind Texas Tech, the Hurricanes picked up where they left off by easily covering the 23.5 points last week at Stanford.
- With that said, Hurricanes coach Mario Cristobal has failed to cover in five of eight games vs. FCS opponents, including a 1-3 ATS record as Miami's head coach and a 2-2 mark while at Oregon.
- The lone cover at Miami was by a half-point over Florida A&M in the two schools' last matchup in 2024, a 56-9 throttling.
- In that last matchup, Miami dominated in yardage (549-190), but even that 47-point victory would fall well short of Thursday's otherworldly spread.
- The Rattlers are 1-1 ATS this season and 2-2 ATS against FBS opponents over the last two campaigns.
Make your Florida A&M vs. Miami prediction on PrizePicks now!
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Can Miami superstars Darian Mensah and Malachi Toney continue to put up huge numbers for the Hurricanes, or will FCS Florida A&M pull off a stunning upset at Hard Rock Stadium to start college football’s Week 2 action?
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