Fantasy Football Buy Low, Sell High for NFL Week 6: Kyler Murray, Jaylen Warren

It was an exciting week in the NFL, featuring three overtime games, eight one-possession wins, and an eight-second lead that wasn't enough for a win.

Entering Week 6, it's time to assess where fantasy football rosters stand, with trade candidates to help you win your fantasy football championship.

Let’s analyze a group of players to buy low or sell high for NFL Week 6 in fantasy football, paired with how each player could perform based on PrizePicks projections in Week 6.

Make your Week 6 NFL predictions on PrizePicks — including players and game winners!

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2026 Fantasy Football Buy Low Players for Week 6

Here are key buy-low players to consider trading for in Week 6, along with their PrizePicks projections this week.

All stats via PFF, NFL Next Gen Stats, and rankings via FantasyPros.

Vikings QB Kyler Murray – Buy Low

Week 6 Matchup: Bye

In Week 5, the Vikings saw the Murray they hoped for. His dual-threat abilities showed up, with 229 passing yards and 51 rushing yards. This feels like only the tip of the iceberg.

Skol Nation also saw the potential of Murray and Vikings WR Justin Jefferson’s connection. Jefferson caught 6 of 7 targets for 79 yards and a TD, leaping over three Saints defenders in the end zone.

The Vikings are 5-0, and they’ve done it without a healthy offense. Murray and Jefferson have missed time, and in the Week 5 win over the Saints, they were without WR Jordan Addison, RB Jordan Mason, and TE T.J. Hockenson, who left early with a concussion. 

If this offense gets healthy, it could help Murray and push his fantasy value even further.

This might be the best week to grab Murray given his upcoming schedule. He’s on a bye this week, so he won’t help his current manager. Over the next three games, he faces the Colts, Lions, and Bills, all ranked in the bottom six in fantasy points allowed per game to QBs.

Pick Kyler Murray + Vikings to cover the spread on PrizePicks now!

Cardinals WR Michael Wilson – Buy Low

Week 6 Matchup: @ Rams

The Cardinals made a blockbuster trade over the weekend, sending their former first-round pick, WR Marvin Harrison Jr., to the Texans. The move benefited all sides: Harrison Jr. wasn't contributing to the Cardinals’ offense, with just 85 yards on 5 catches and 1 TD. This gives Harrison Jr. a fresh start alongside his former Ohio State teammate, QB C.J. Stroud.

With Harrison Jr. out of the picture, Wilson is now Arizona's WR1. Unfortunately, despite what should have been a favorable matchup against a Lions defense that has allowed the fourth-most fantasy points per game to wide receivers (26.0), he finished with just 7.3 fantasy points and ranks as the WR45.

He had minimal involvement in the offense, recording season lows in route participation rate (83.0%), target share (14.6%), and air yards share (14.6%).

Without Harrison Jr., Wilson could draw all the attention in the secondary; the offense will need to adjust as the weeks progress.

Wilson could be the better value because Trey McBride is this offense's marquee pass-catcher. With the Cardinals ranking sixth in the league in passing play percentage (64.5%), Wilson should keep getting targets. 

Michael Wilson vs. Rams Projections for Week 6

Here are Wilson’s projections vs. the Rams via PrizePicks — pick More or Less on player stats to cash in every week.

• 0.5 Anytime TDs (Demon)

Pick Michael Wilson + Cardinals to win on PrizePicks now!

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Saints WR Devaughn Vele – Buy Low

Week 6 Matchup: @ Giants

After 54 receiving yards and 1 TD in Week 4 against the Falcons, Vele was a hot pickup last week. He rewarded his new fantasy managers with just 6.6 fantasy points in Week 5 against the Vikings.

This was a tough matchup against a Minnesota defense that ranks seventh in fantasy points allowed per game to wide receivers (16.9). No one on the Saints played well, with QB Tyler Shough finishing with 1.8 points and WR Chris Olave with 8.6.

Vele could rebound quickly against the Giants, who rank 15th in fantasy points allowed per game to wide receivers (19.9). He’s been a key part of the Saints’ passing game. According to PlayerProfiler, Vele ranks sixth among wide receivers in red zone targets (6) and 13th in first-read targets (24).

Devaughn Vele vs. Giants Projections for Week 6

Here are Vele’s projections vs. the Giants via PrizePicks — pick More or Less on player stats to cash in every week.

• 29.5 Receiving Yards
• 0.5 Anytime TD (Demon)
• 18.5 Longest Reception

Pick Devaughn Vele + Saints to cover the spread on PrizePicks now!

2026 Fantasy Football Sell High Players for Week 6

Here are some key players to sell high on for fantasy football after overachieving, plus their projections on PrizePicks this week.

Commanders RB Jacory Croskey-Merritt – Sell High

Week 6 Matchup: @ 49ers

Croskey-Merritt had his best game of the year in Week 5 against the Giants, with 11 carries for 82 rushing yards, and his first rushing TD since Week 1. 

But he didn’t even have the best performance of the game on the ground; Commanders QB Jayden Daniels finished with 102 rushing yards and 2 TDs. 

One reason he may not be able to replicate this performance consistently is that the volume could lack. The backfield is crowded: Rachaad White returned after missing Week 4’s game against the Seahawks and had 7 carries, newly signed RB Austin Ekeler had 3 carries, and there’s Daniels, who finished second among quarterbacks in rush attempts in 2024 (148).

JCM hasn’t been productive enough to justify a heavy workload either. Heading into Week 5, he ranked 39th in the league in yards per carry (3.0) and 35th in yards after contact per carry (2.3).

Last season, Croskey-Merritt rushed for more than 80 yards four times; he followed up with less than 30 rushing yards three times. This might be the best time to get a good return before he potentially falls back to Earth.

Jacory Croskey-Merritt vs. 49ers Projections for Week 6

Here are Croskey-Merritt’s projections vs. the 49ers via PrizePicks — pick More or Less on player stats to cash in every week.

• 45.5 Rushing Yards
• 2.5 Receiving Yards
• 0.5 Anytime TDs (Demon)

Pick Jacory Croskey-Merritt + Commanders to cover the spread on PrizePicks now!

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Buccaneers RB Bucky Irving – Sell High

Week 6 Matchup: vs. Steelers

Expectations were that, with Rachaad White gone, Irving would lead the Tampa Bay backfield. As many drafters sipped the Kool-Aid and took Irving as a top-15 running back.

Entering Week 5, Irving was the RB22. After his 30.55-point game against the Cowboys, he surged to RB13.

Irving delivered an amazing performance in Dallas, totaling 175 yards from scrimmage and scoring 2 total TDs. However, the Cowboys rank 27th in fantasy points allowed to running backs (21.9). He broke off a few big runs, including a 22-yard carry that sealed the win.

The problem for Irving is that he’s not getting the snap share expected of a workhorse back. There’s been a decline in snaps recently, with an average of a 54.6% snap share over the last three games, compared to 69.5% in his first two.

Bucky Irving vs. Steelers Projections for Week 6

Here are Irving’s projections vs. the Steelers via PrizePicks — pick More or Less on player stats to cash in every week.

• 63.5 Rushing Yards
• 0.5 Anytime TDs (Demon)

Pick Bucky Irving + Buccaneers to cover the spread on PrizePicks now!

Steelers RB Jaylen Warren – Sell High

Week 6 Matchup: @ Buccaneers

After this week, there may not be a better opportunity to get Warren's best trade return. Last week was a career performance with his personal best 36.8 fantasy points, finishing as the RB2. 

Following the game, Steelers head coach Mike McCarthy shared positive news about Warren’s role in the offense. The plan was a 50/50 split, but after RB Rico Dowdle’s foot injury, Warren has become the “feature player” thanks to his play.

Since Week 3, he ranks second in the league in rushing yards (321) and third in yards after contact (213).

Warren may still get most of the carries, but Dowdle will find his way back into the mix. That may happen as early as this week, as Dowdle could return. 

This is a chance to get a great return for a middle-round running back.

Jaylen Warren vs. Buccaneers Projections for Week 6

Here are Warren’s projections vs. the Buccaneers via PrizePicks — pick More or Less on player stats to cash in every week.

• 1.5 Anytime TDs (Demon)

Pick Jaylen Warren + Steelers to cover the spread on PrizePicks!

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Make Week 6 NFL Picks on PrizePicks

No matter where your fantasy football team stands, you can always improve. Whether you’re trading for a player who could add value or trading away a player whose value has peaked.

If you want to manage a different lineup each week throughout the NFL season, that's possible as well. Don’t wait until kickoff — make your NFL picks on PrizePicks now and earn real money if you’re right.

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