Eagles vs. Jaguars Prediction, Spread, NFL Picks for London Game – 10/11/26

For the second straight week, the NFL slate gets underway in London, with the Philadelphia Eagles facing the Jacksonville Jaguars at Tottenham Hotspur Stadium at 9:30 a.m. ET on Sunday, October 11, on NFL Network.

On Sunday, the Jaguars are 7.5-point favorites against the Eagles on PrizePicks. Jacksonville comes off a hard-fought 22-17 win over the Cincinnati Bengals in Week 4, while Philadelphia suffered a 24-20 loss to the Los Angeles Rams. 

Below, we’ll break down our Eagles vs. Jaguars prediction and picks for Sunday’s NFL London game, including the spread, over/under, and key player picks for PrizePicks.

Make your Eagles vs. Jaguars prediction and picks on PrizePicks now!

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Eagles vs. Jaguars Prediction, Spread, Over/Under for London Game – Sunday, October 11

The Jaguars enter Sunday’s game as 7.5-point favorites against the Eagles, returning a 1.25x payout if they win outright, via PrizePicks — or an estimated $125 on a $100 entry if you're right.

Here are the full payouts for the Eagles vs. Jaguars game on PrizePicks. PrizePicks data is live at the time of writing and is subject to change. 

Make your Eagles vs. Jaguars prediction on the spread on PrizePicks!

Under head coach Liam Coen, the early returns have been nothing short of exceptional. The Jaguars went 13-4 in 2025 and made the playoffs in Coen’s first season.

In the early portion of the 2026 season, the Jaguars have gotten off to an impressive 3-1 start. Jacksonville’s lone loss came in a 20-13 defeat against the Denver Broncos in Week 2, but its outscored the New England Patriots and Bengals 57-23 in the past two weeks.

QB Trevor Lawrence has tallied the fifth-best total EPA (31.66) among NFL QBs, behind only Brock Purdy (59.24), Lamar Jackson (36.24), Jared Goff (34.92), and Dak Prescott (31.92). Lawrence has completed a career-high 69.2% of his passes for 843 yards and 8 TDs, with just 2 INTs. 

As magnificent as the Jaguars have been through the air, the team’s rushing attack has been just as productive. Jacksonville has averaged 4.2 yards per carry (tied for eighth) and posted the fifth-best EPA/rush (0.03). 

The Jaguars have thrived on the ground, despite 2025 leading rusher Travis Etienne Jr. signing with the New Orleans Saints in free agency. Still, Jacksonville has leaned on RB Bhayshul Tuten (4.6 yards per carry) and Chris Rodriguez (4.2 yards per carry) to pace its running game. 

Meanwhile, the Eagles have had a whirlwind week after falling to the Rams in Week 4. Philadelphia was dealt a tough blow earlier this week when OT Lane Johnson announced his retirement. Johnson had been inactive in Week 4 due to personal reasons.

Later in the week, the team traded offensive lineman Cam Juergens to the Baltimore Ravens, shaking up the offensive line. 

The Eagles won their first two games in 2026, beating the Washington Commanders and Tennessee Titans by 6 total points. However, Philadelphia has dropped its last two contests, including a Week 4 loss to the Rams.

Many of the Eagles’ struggles have come on offense throughout the 2026 campaign. Philadelphia has averaged just 18.8 points per game (26th). This comes after the franchise traded star WR A.J. Brown to the New England Patriots in the offseason. 

QB Jalen Hurts will be without top WR DeVonta Smith (hamstring), who assumed the WR1 role this season. This could loom large as Hurts has registered just 6.3 yards per passing attempt (31st among QBs), according to PlayerProfiler. His 713 passing yards also rank 24th among QBs, and he passed for a season-low 93 yards in Week 4.

Aside from Smith, the RB position has been hit hard by injuries in the past week. The Eagles will be without star RB Saquon Barkley in Week 5 after he suffered a hamstring injury against the Rams. Meanwhile, RB Tank Bigsby was placed on injured reserve after suffering a core muscle injury.

The Eagles haven’t had much success when it comes to the spread recently. Philadelphia is 0-6 against the spread dating back to the 2025 season.

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Eagles vs. Jaguars Prediction on Spread for London Game – 10/11/26

Here are the key stats and trends behind our Eagles vs. Jaguars prediction on the spread for Sunday, October 11.

• The Jaguars have recorded a 0.14 EPA per play (second in the NFL).
• Jacksonville’s offense has really been electric this season. According to RBSDM, the Jaguars have registered a 50.4% dropback success rate (eighth) with QB Trevor Lawrence under center.
• Speaking of Lawrence, the Jaguars QB has averaged 8.0 yards per pass attempt, ranking eighth among NFL signal-callers.
• Despite having several playmakers on defense, the Eagles have surrendered a 0.03 EPA/pass (23rd).
• Philadelphia has given up 23.3 points per game this season, which ranks 17th in the league. The Eagles also allow 222.0 passing yards per game (16th), opening the door for the Jaguars’ talented passing attack to potentially take advantage. 
• Meanwhile, the Eagles average just 18.8 PPG (26th) and have the second-fewest passing yards per game (160.8). In contrast, the Jaguars are holding opponents to -0.09 EPA/pass (seventh).

Make your Eagles vs. Jaguars picks now for Sunday’s NFL game.

Eagles vs. Jaguars Picks, Player Stats for PrizePicks: 10/11/26

Here are the top Eagles vs. Jaguars picks to target on Sunday, October 11. Today’s NFL picks for PrizePicks include Bhayshul Tuten and Zay Flowers.

Jaguars RB Bhayshul Tuten vs. Eagles: 65.5 Rush Yards

• Tuten has carried the ball 60 times for 277 yards and 2 TDs, while averaging 4.6 yards per carry.
• The former Virginia Tech standout’s 277 yards rank 13th among NFL RBs, despite having just a 50.9% snap share (25th among RBs).
• Tuten has rushed for 66+ yards in three of his four contests in 2026.
• Ranking 10th among NFL RBs, the Jaguars RB has 16 evaded tackles (4.0 per game) this season.
• Tuten has tallied 222 yards after contact (eighth among RBs), per SumerSports.
• Additionally, the Eagles have allowed the 10th-most rushing yards per game (122.0).
• The Philadelphia defense has also surrendered a -0.02 EPA/rush in four games (23rd).

Add Bhayshul Tuten + Jaguars to cover the spread to your PrizePicks lineup now.

Eagles RB Will Shipley vs. Jaguars: 15.5 Receiving Yards

• Shipley will get his second career start on Sunday, with RBs Saquon Barkley (hamstring) and Tank Bigsby (abdomen) both out.
• In the 2024 season finale against the New York Giants, the Eagles sat Barkley and several offensive stars. In that contest, Shipley tallied just 32 rushing yards on 10 carries but thrived in the receiving game, catching 4 passes for 35 yards.
• Shipley has run 53 routes this season, ranking 23rd among RBs.
• The former Clemson star has caught 4 passes for 24 yards in 2026 and has established himself as a talented pass-catching RB.
• The Jaguars allow the second-most receiving yards (193) to opposing RBs this season, per The Football Database.

Add Will Shipley + Eagles to win to your PrizePicks lineup now.

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Make Eagles vs. Jaguars Picks on PrizePicks

The Jacksonville Jaguars look to continue their impressive start as a sizeable favorite against the Philadelphia Eagles. Can the Jaguars take advantage of a shorthanded Eagles squad across the pond? 

Don't wait until kickoff — make your Eagles vs. Jaguars picks on PrizePicks now for Week 5 and earn real money if you're right.

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