The Eagles vs. Cowboys rivalry is a time-honored tradition. Right up there with the Packers-Bears and Steelers-Browns, these two teams are enemies and bring a competitive fight. When the two NFC East squads face off on Sunday (4:25 pm. ET on FOX), there could be fireworks.
The Eagles won the first matchup of the 2025 slate, 24-20, when they played on opening night of the season. The game started off with a bang, as Eagles star DT Jalen Carter was ejected for spitting on Cowboys QB Dak Prescott before the game even began. Philly would go on to sneak a victory thanks to their run game and a couple of key defensive stops.
Let's dive into an Eagles vs. Cowboys prediction and NFL picks for Sunday's Week 12 bout. Use PrizePicks to make picks on player projections for this weekend and beyond.
Eagles vs. Cowboys Prediction, Week 12 Preview
In this top-tier matchup between bitter rivals, let’s preview each team and see how they stack up against one another. PrizePicks offers several intriguing picks on projected player stats.
Philadelphia Eagles Preview vs. Cowboys
The Eagles continue to get banged up, both in the media and on the field. Looking at some injuries, the defending Super Bowl champions lost star OT Lane Johnson to yet another injury, as he suffered a Lisfranc foot injury in last week’s game and could be out several weeks.
C Cam Jurgens was also injured again but returned to practice, which is a welcome sign for the Eagles as they look to get some consistency back in their offensive line.
Publicly, the Eagles are struggling with some perception issues. WR A.J. Brown has been in and out of the news all season long, with questions about his abilities and whether he would even entertain a trade. The team has forged ahead by continuing to win, but the questions about their offensive cohesiveness remain.
With one of the best defenses in the league right now, allowing an average of just 15 points across their last six games, the Eagles are choosing the “show it on the field” method of responding to outside noise.
Dallas Cowboys Preview vs. Eagles
At times this season, the Cowboys have looked like an offensive juggernaut, with five games of at least 33 points scored. On the other hand, they’ve also allowed 30+ points in five games, highlighting key issues on the defensive side of the ball.
Prescott, aided by the arrival of WR George Pickens, has played MVP-level football on occasion. He’s having one of his best statistical seasons, ranking sixth in passing yardage, second in TD passes, and fourth in completion percentage.
It hasn’t translated into wins, however, because the Cowboys have truly struggled on defense. They give up the third-most passing yards, ninth-most rushing yards, and the second-most points per game.
Eagles vs. Cowboys Same-Game Picks for PrizePicks
Here are two Eagles vs. Cowboys same-game player picks for Week 12, spotlighting key projections to watch for RB Saquon Barkley and WR CeeDee Lamb.
You can choose More or Less on these projections on PrizePicks — along with plenty of others — for a chance to win real money this NFL season.
Eagles RB Saquon Barkley Projection vs. Cowboys: 16.5 Receiving Yards
Despite not always looking like his best self, Barkley is still a force of nature and is plenty involved in the receiving game.
The reigning Offensive Player of the Year has had more than this projection in five of his 10 games this year. He had 24 yards on 4 receptions against the Cowboys earlier this year and has reached 24+ receiving yards in two of his last three games.
The Cowboys allow 44.5 receiving yards per game to RBs, per Lineups, which is the third-highest number in the NFL.
After comments from Brown this week deflected some attention onto Barkley, the superstar RB may come out looking to make a statement in this rivalry game.
Cowboys WR CeeDee Lamb Projection vs. Eagles: 6 Receptions
In Week 1, Eagles DC Vic Fangio chose to blanket Pickens with CB Quinyon Mitchell instead of shadowing Lamb. This resulted in Lamb catching 7 balls for 110 yards, and it is projected by Mike Clay’s Shadow Report, which tracks WR/CB matchups, that the Eagles could go back to that again.
Against Philadelphia, Lamb typically plays up a level. In each of his last five games against the Birds, Lamb has had at least 6 catches. This week could be no different.
With Mitchell’s attention focused on stopping Pickens downfield, it will be up to CB Adoree’ Jackson, who has struggled at times, to defend Lamb when he gets into single coverage.
Make Eagles vs. Cowboys Picks on PrizePicks
Who comes out on top for this Week 12 divisional rival battle between the Eagles and the Cowboys? You can make your choice on PrizePicks.
When you play on PrizePicks NFL DFS, you can turn your knowledge into real-money wins. Pick your players, predict More or Less on projections, and submit your picks for a shot at cash.
For season-long DFS strategy, player insights, and expert analysis, PrizePicks and the Playbook are your best resources.
