Eagles vs. Chiefs Prediction, NFL Picks for Week 2: Jalen Hurts, Patrick Mahomes

For the second time this calendar year, two of the NFL’s best will square off. The must-see game from Sunday’s slate is a regular-season rematch of Super Bowl LIX between the Philadelphia Eagles and Kansas City Chiefs.

The inter-conference meeting (4:25 p.m. ET, FOX) features two loaded rosters led by Philly QB Jalen Hurts and his K.C. counterpart, Patrick Mahomes

Below, we’ll list some Eagles vs. Chiefs same game NFL DFS picks to monitor. PrizePicks makes it even more fun to follow the NFL weekend! Make your Week 2 predictions for a chance to win real money.

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Eagles vs. Chiefs Prediction, Preview for 9/14/25

• Something’s gotta give in this AFC-NFC rivalry. The series is all knotted up at 6-6 dating back to 1972, with the Eagles riding a two-game winning streak.
• Prior to that, the Chiefs rattled off four consecutive wins (including Super Bowl LVII). Each of those victories came with future Hall of Fame coach Andy Reid already having departed Philadelphia for Kansas City.
• Week 2 marks the 11th regular-season rematch of a Super Bowl in the following campaign, among various other interesting Eagles vs. Chiefs stats to keep in mind.

Philadelphia Eagles Preview

• Philadelphia’s regular-season opener was closer than many expected. A 24-20 victory saw neither they nor the Dallas Cowboys score in the final frame.
• Advanced stats painted a mixed picture of the performance. The reigning champs posted the No. 8-ranked EPA/play output on offense (per rbsdm.com) but were 20th on defense.
• Sunday is a chance for head coach Nick Sirianni’s group to get fully back on track and flex its muscles as the Lombardi winners.

Kansas City Chiefs Preview

• The Chiefs started this season how their last campaign ended: With a loss. They couldn’t overcome an in-game injury to WR Xavier Worthy and a leaky defense against the LA Chargers in São Paulo, Brazil.
• Worthy has since returned to practice, albeit in a limited capacity. Without him, Kansas City eventually found its footing and scored on its final five possessions. Can defensive coordinator Steve Spagnuolo’s crew hold up their end of the bargain this against Philly?
• Just four teams have reached the Super Bowl after starting 0-2.

Eagles vs. Chiefs Same Game Picks for NFL DFS & PrizePicks

Below are three key Eagles vs. Chiefs NFL DFS same game picks to consider. Week 2’s Sunday matchup features PrizePicks projections for Jalen Hurts, A.J. Brown and Patrick Mahomes, and a wide receiver looking for redepmtion.

Eagles QB Jalen Hurts: 206.5 Pass Yards

• Hurts opened the year completing 19 of 23 passes, albeit for just 152 yards. That was good enough to rank second among all QBs in EPA+CPOE (expected points added + completion percentage over expected) composite for Week 1, though.
• Last season, Hurts failed to hit the 200-yard threshold six times between Weeks 1-15 and twice in four playoff games.

Eagles WR A.J. Brown: 68.5 Receiving Yards

• Brown had as rough a Week 1 as just about any player. His 1 catch for 8 yards marked his worst single-game output since Week 11 of the 2023-24 season.
• Coincidentally, the aforementioned matchup was against none other than Kansas City. Then-Chief L’Jarius Sneed covered Brown on each of his 4 targets, per Pro Football Focus.
• Who lines up against Brown could determine how much of a rebound performance he has in Week 2. Trent McDuffie, Kristian Fulton, and Jaylen Watson are all candidates for that job.

Chiefs QB Patrick Mahomes: 25.5 Rush Yards

• Mahomes threw for 258 yards in Week 1, but his biggest impact was on the ground. His 57 rushing yards were his fifth-most in a regular-season game.
• The two-time NFL MVP toted the ball four times in February’s Super Bowl, amassing 25 yards.
• In two non-playoff outings against Philly, Mahomes averaged 32 rushing yards per game. This weekend could feature another quick passing game with some scrambles mixed in.

Make Eagles vs. Chiefs Picks on PrizePicks

Even with plenty of football left to play in 2025, it doesn’t get much more high-stakes than this. Eagles vs. Chiefs presents ample opportunities for both sides, in addition to football fans seeking an NFL DFS fix.

Get in on the fun with PrizePicks! Make your Eagles vs. Chiefs picks with player projections for Jalen Hurts, A.J. Brown, or Patrick Mahomes. Simply find your players, predict More or Less for their stats, and add those selections to your Lineup. 

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