The first full week of college football is nearly over, but the absence of NFL games and the holiday weekend gives us a rare Sunday slate of action. It all kicks off at 4:00 p.m. ET on Sunday, September 6, with the Apple Cup between Washington State and #17 Washington.
The slate finishes with two games kicking off at 7:30 p.m. ET. Wisconsin and #4 Notre Dame collide in the legendary Lambeau Field, while #24 Louisville takes on #9 Mississippi in Nashville for the weekend’s only matchup of top-25 opponents.
Below is the full Week 1 college football schedule for Sunday, including how to watch or stream every game, and point spreads via PrizePicks.
You can make picks on NCAAF game winners and spreads in eligible states, and add Player Picks to the same lineup for even bigger payouts all season long!
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College Football Games Today: Week 1 Schedule, TV Channels & Spreads
All game times in Eastern. Spreads and winner payouts are live PrizePicks Team Picks as of posting but are subject to change.
Payouts below — like 2.94x — represent real-money multipliers on correct picks on PrizePicks Team Picks at the time of writing. For example, a $10 entry on Louisville to win at a 2.94x multiplier would pay out $29.40 if you're right.
See live payouts and spreads in the PrizePicks app — new users get $150 if you win your first $5 lineup with code PLAYBOOK!
PrizePicks Team Picks data is live as of writing and is subject to change.
How to Watch College Football Games Tonight – Sunday, September 6
There are only three games on Sunday night, but you won’t need anything more than an antenna to watch them. The early game kicks off at 4:00 p.m. ET on NBC with Washington State vs. #17 Washington, with the Huskies favored by 23.5 points.
These two rivals used to finish their season against one another, but conference realignment now sees them playing in September for the third straight year. However, this will be the first time they’ve opened the season with the Apple Cup in the 126-year history of the rivalry.
The 7:30 p.m. ET window features two games in neutral stadiums. Wisconsin and #4 Notre Dame meet at Lambeau Field in Green Bay, Wisconsin, with the game airing on NBC.
The Fighting Irish are 20.5-point favorites and will be wearing a special “Acme Packers” uniform and are one of the top favorites to win the national championship with QB CJ Carr at the helm.
ABC will carry what is the only matchup of ranked opponents this weekend, as #24 Louisville faces #9 Mississippi in Nashville at 7:30 p.m. ET in what could be the best game of the week.
The Cardinals are a popular upset pick this weekend over the Rebels, who are 6.5-point favorites. To get the win, they’ll have to slow down the Rebels and their dangerous offense led by QB Trinidad Chambliss and RB Kewan Lacey.
Sunday Week 1 Spreads, Winners & Potential Payouts on PrizePicks
The rest of Week 1 is on the PrizePicks board now. In eligible states, you can make picks on college football winners, spreads, and totals. Then add Player Picks to the same lineup for bigger potential payouts.
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More College Football Week 1 Picks & Predictions for Sunday
Need some expert picks and predictions before you lock in your college football lineup? Tap into the Playbook’s Week 1 research from our experts for Sunday's slate:
- Washington State vs. #17 Washington Prediction, Spread & Picks
- Wisconsin vs. #4 Notre Dame Prediction, Spread & Picks
- #24 Louisville vs. #9 Ole Miss Prediction, Spread & Picks
- Week 1 College Football TD Scorer Predictions
Stay locked in on the Playbook college football hub for fresh picks, predictions, spreads, and game previews throughout the 2026 college football season!
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state.Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results.Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
