We’re in the thick of conference play for Week 6 of the college football season. Saturday, October 10, is headlined by only two top-25 matchups, but several top-25 squads are in store for tough tests in this week’s CFB schedule.
Several season-shifting matchups are on the docket. Nebraska hopes to grab a signature win vs. #7 Indiana (-7.5) on FOX, followed by #21 UCLA vs. #13 Oregon (-10.5) for another Big Ten battle on CBS.
The SEC is led by one of the season’s best games between #2 Georgia and #6 Alabama (-2.5), airing alongside #10 LSU (-9.5) taking on Kentucky in a hostile environment at 7:00 p.m. ET on ESPN. We can’t forget about the must-see Red River Rivalry between #1 Texas (-7.5) and Oklahoma, kicking off at 3:30 p.m. ET on ABC.
We’ll look at the full Week 6 college football schedule for Saturday’s games, how to watch each contest with TV channels, capped by current spreads and winner payouts on PrizePicks Team Picks — now available in 36 states!
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College Football Games Today: NCAAF Week 6 Schedule, TV Channels, & Spreads
All CFB game times are in Eastern Time. Spreads and winner payouts are live on PrizePicks Team Picks as of posting and are subject to change.
Below, our schedule features all teams in the AP Top 25 Poll, featuring the best CFB games to watch today. Times and TV channels are based on ESPN’s CFB schedule.
Payouts below, such as 2x, represent real-money multipliers on correct picks on PrizePicks Team Picks at the time of writing. For example, a $100 entry on Georgia to win at a 2x multiplier would pay out $200 if you’re right.
Check out live payouts and spreads on the CFB board in the PrizePicks app — new users get $150 if you win your first $5 lineup with code PLAYBOOK!
Spreads are via PrizePicks — make college picks on spreads and winners now!
How to Watch College Football Games Today – Saturday, October 10
If you desire, you can rot on your couch all day long watching college football. Saturday, October 10, is jam-packed with 46 FBS matchups on the schedule, beginning at 12:00 p.m. ET and running through 10:30 p.m. ET kickoffs on the West Coast.
From 12:00 p.m. ET to 2:00 p.m. ET, five top-25 squads are in action. No game could be more intriguing than #7 Indiana paying a visit to Nebraska (FOX), which has one of the most underrated home atmospheres in all of college football.
The Cornhuskers are still chasing a signature win in head coach Matt Rhule’s four-season tenure. Nebraska has appeared in two bowl games with one bowl win over his last three seasons, but with a 5-0 start, the Cornhuskers are looking to put the nation on notice.
This could be a trap game for #7 Indiana, which plays host to #5 Ohio State next week. The Hoosiers have only played Rutgers on the road thus far, and they’ve mostly underachieved with a 1-4 against the spread (ATS) record despite a 5-0 start.
Elsewhere, #14 Missouri looks to avoid a letdown following last week’s massive 45-17 win over then-#8 Florida. The Tigers play host to Texas A&M for a 12:00 p.m. ET kickoff on ABC.
Outside #4 Miami, the ACC has been pretty quiet, but #25 Pittsburgh has the chance to make noise vs. North Carolina (ESPN).
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Entering the afternoon slate, we’ve got some bangers on hand.
The Big Ten has one top-25 matchup this week between #21 UCLA vs. #13 Oregon (CBS). The Ducks have improved since a 39-31 loss vs. Oklahoma State on September 12, but they will start QB Dylan Raiolo following QB Dante Moore’s scary head injury last week.
UCLA is flourishing in head coach Bob Chesney’s first season with a 4-0 record, but its beat the likes of California, San Diego State, Purdue, and Maryland. It’s time for a real win.
One of the best rivalries in sports goes down at the Cotton Bowl in Dallas, Texas, with #1 Texas vs. Oklahoma (ABC). The Red River Rivalry is lacking the same preseason hype due to OU’s poor start, but the Sooners can spoil the Longhorns’ perfect 4-0 start.
Kentucky is another program enjoying a strong start under a first-year coach, with Will Stein orchestrating a 4-1 start. Lexington is set for one of its best home environments in years, as Lane Kiffin and #10 LSU come to town for a 7:00 p.m. ET start on ESPN.
Now, we get to one of the best college football matchups of the season. Through five weeks, #2 Georgia and #6 Alabama have arguably been the two best teams in the nation.
According to PrizePicks, Georgia (5.26x) and Alabama (7.14x) feature the second- and fifth-shortest payouts to win the national championship. Alabama QB Keelon Russell could also make a serious push for the Heisman Trophy, as he faces one of the nation’s top defenses. The SEC heavyweights duke it out at 7:30 p.m. ET on ABC.
Finally, the late-night slate is headlined by Kansas vs. #12 Utah (ESPN) and #23 Boise State vs. Fresno State (CW).
Must-Watch NCAAF Games Today – Saturday, October 10
These games should be front and center for your viewing pleasure. Check out our games of the week for Week 6 on Saturday, October 10, including how to watch each bout.
Best NCAAF Noon Games to Watch Today
Games starting at 12:00 p.m. ET on Saturday.
- #7 Indiana vs. Nebraska – FOX
- Texas A&M vs. #14 Missouri – ABC
- UCF vs. #18 Oklahoma State – ESPN2
- North Carolina vs. #25 Pittsburgh – ESPN
- South Carolina vs. #16 Florida – 12:45 p.m. ET on SEC Network
Best NCAAF Afternoon Games to Watch Today
Games starting between 2:00 p.m. ET and 4:00 p.m. ET.
- #1 Texas vs. Oklahoma – ABC
- #9 Ole Miss vs. Vanderbilt – ESPN
- Stanford vs. #3 Notre Dame – NBC
- #21 UCLA vs. #13 Oregon – CBS
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Best NCAAF Night Games to Watch Today
Games starting between 5:00 to 8:00 p.m. ET tonight.
- #10 LSU vs. Kentucky – ESPN
- #2 Georgia vs. #6 Alabama – ABC
- #19 USC vs. Penn State – NBC
Best NCAAF Late Night Games to Watch Today
Games starting past 8:00 p.m. ET to 11:00 p.m. ET tonight.
- Kansas vs. #12 Utah – ESPN
- #23 Boise State vs. Fresno State – CW
- Hawai’i vs. Arizona State – FS1
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Week 6 NCAAF Spreads, Winners, Payouts Today on PrizePicks
This week could focus on keeping an eye out for upsets. Some of Week 6’s best matchups still feature heavy spreads on PrizePicks, such as #10 LSU (-7.5) vs. Kentucky, #7 Indiana (-7.5) vs. Nebraska, #1 Texas (-7.5) vs. Oklahoma, and #21 UCLA vs. #13 Oregon (-10.5).
Oregon is at home, while Texas is in a neutral site. However, LSU and Indiana are both in conference road environments against programs hungry to finally be taken seriously.
The noon slate has several tight spreads, including North Carolina vs. #25 Pittsburgh (-3.5) and Texas A&M vs. #14 Missouri (-3.5).
As the crown jewel of Week 6, #6 Alabama is -2.5 in Saturday night’s home game vs. #2 Georgia. The favorite to win the SEC championship could have a notable shift after this one, as Georgia (2.56x) and Alabama (3.84x) currently have the shortest payouts to win the conference on PrizePicks.
Hurricane Isaias is hitting the Gulf Coast, expected to make landfall on Friday night. Georgia vs. Alabama could dodge most of the harsh conditions, but Accuweather is forecasting a 61% chance for rain on Saturday night in Tuscaloosa.
Alongside Week 2’s thrilling #1 Ohio State vs. #4 Texas game, #2 Georgia vs. #6 Alabama is gearing up to be one of 2026’s top college football games. We’ve got Heisman hopefuls, NFL prospects, and championship contenders all on one field — grab your popcorn.
The full Week 6 slate is on the PrizePicks board now, with projections and picks available for every game. In eligible states, you can make picks on college football winners, spreads, and totals. Then add Player Picks to the same lineup for bigger potential payouts.
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Make Saturday College Football Picks & Predictions on PrizePicks
Saturday’s Week 6 schedule is headlined by #2 Georgia vs. #6 Alabama, featuring one of the lowest point spreads of the week. However, several teams could be on upset alerts, including #7 Indiana, #1 Texas, #13 Oregon, and #10 LSU.
Need some expert college football picks and predictions before you lock in today? Tap into the Playbook’s Week 6 CFB expert research to get coverage on the top games.
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