College football Week 6 hits Friday night with five games taking center stage, and three of them are Power 4 matchups on national TV. With no NFL or MLB today, all eyes will turn to Friday's NCAA football games and thw WNBA Semifinals.
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Friday's Week 6 college football schedule kicks off at 7 p.m. ET with Florida State vs. Louisville in the ACC, with Louisville -3.5 on ESPN. On the late slate, starting at 9 p.m. ET, #20 Iowa visits Washington (-10.5) on FOX, while #7 BYU (-10.5) hosts Iowa State at 10:15 p.m. ET on ESPN in a Big 12 showdown to close the night.
Both ranked teams come in banged up. Iowa is an underdog in Seattle with starting QB Hank Brown questionable with a sprained throwing shoulder, and BYU defends its 4-0 start without star RB LJ Martin.
Washington State-Utah State (The CW) and Wyoming-San José State (CBS Sports Network) round out the 9 p.m. ET window.
Below is the full Week 6 college football schedule for Friday's games, how to watch or stream every NCAAF game, and current spreads via PrizePicks Team Picks — now available in 34 states!
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Friday College Football Games Today: Week 6 Schedule, TV Channels, & Spreads
All game times are in Eastern Time. Spreads and winner payouts are live on PrizePicks Team Picks as of posting, but are subject to change.
Payouts below — like 2x — represent real-money multipliers on correct picks on PrizePicks Team Picks at the time of writing. For example, a $10 entry on Louisville to win at a 1.53x multiplier would pay out an estimated $15.30 if you're right.
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How to Watch College Football Games Tonight – Friday, October 9
With kickoffs at 7:00, 9:00, and 10:15 p.m. ET, tonight's five-game slate spans four networks. ESPN has Florida State-Louisville and Iowa State-BYU, FOX has Iowa-Washington, The CW has Washington State-Utah State, and CBS Sports Network has Wyoming-San José State.
The 10:15 p.m. ET kickoff in Provo is the nightcap, and BYU carries the biggest spread of the night at 10.5 points; that spread was as high as 14 points this week. Before that, three games kick off at 9 p.m. ET, led by Iowa-Washington in the Big Ten on FOX, where the unranked home team is favored by 2.5.
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How to Watch Florida State vs. Louisville – Friday, October 9
Florida State vs. Louisville is set for a 7:00 p.m. ET kickoff on ESPN at L&N Federal Credit Union Stadium in Louisville. Louisville is a 3.5-point favorite on the spread, with a 1.53x payout to win outright (2.38x for Florida State), according to PrizePicks.
Florida State (3-2, 1-1 ACC) is coming off a 38-7 win over Virginia, where Ashton Daniels ran for 136 yards and 5 TDs, a record for an FSU quarterback, and the defense racked up 10 sacks.
Louisville (2-3, 1-2 ACC) has lost three games by exactly 3 points each, most recently 31-28 at NC State. Lincoln Kienholz has 1,394 passing yards, 9 TDs, and 1 INT through five games.
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How to Watch #20 Iowa vs. Washington – Friday, October 9
#20 Iowa vs. Washington is set for a 9:00 p.m. ET kickoff on FOX at Husky Stadium in Seattle. Washington is a 2.5-point favorite, with a 1.63x payout to win outright (2.17x for Iowa), according to PrizePicks.
Iowa (4-1, 1-1 Big Ten) is coming off a 31-14 home loss to #5 Ohio State, and Hank Brown is questionable with an AC joint sprain. If Brown can't go, Jeremy Hecklinski gets the start.
Washington (3-2, 0-2 Big Ten) has dropped two straight and ranks 130th nationally on third down, converting 29% of the time, while Iowa's defense allows just 12.6 points per game. It's also Iowa's first trip to Seattle since 1963, which is an interesting narrative on a short week after a drubbing vs. Ohio State last week.
How to Watch Iowa State vs. #7 BYU – Friday, October 9
Iowa State vs. #7 BYU is set for a 10:15 p.m. ET kickoff on ESPN at LaVell Edwards Stadium in Provo. BYU is a 10.5-point favorite on the spread, with a 1.21x payout to win outright (4x for Iowa State), according to PrizePicks.
BYU (4-0, 2-0 Big 12) beat TCU 17-10 in the rain last week, but RB LJ Martin and LB Isaiah Glasker both left in the first half, and both are listed out for Friday. Martin, the reigning Big 12 Offensive Player of the Year, had 344 rushing yards and 3 TDs through four games. Iowa State (3-2, 1-1 Big 12) is coming off a 45-42 shootout win over West Virginia, where RB Aiden Flora ran for 212 yards and 3 TDs and threw 2 TD passes.
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More Friday College Football Games Tonight – Friday, October 9
Washington State vs. Utah State kicks off at 9:00 p.m. ET on The CW at Maverik Stadium in Logan. Utah State is a 5.5-point favorite (1.44x to win; 2.56x for Washington State). Both teams are 1-4, so one of them will leave with its first Pac-12 win. Washington State won last December's Famous Idaho Potato Bowl meeting, 34-21.
Wyoming vs. San José State kicks off at 9:00 p.m. ET on CBS Sports Network at CEFCU Stadium in San Jose. San José State is a 4.5-point favorite (1.49x to win; 2.5x for Wyoming). Wyoming won last year's meeting, 35-28.
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Make Friday College Football Picks on PrizePicks
Both ranked teams headlining Friday's college football slate are dealing with key injuries. #20 Iowa is an underdog in Seattle with its starting QB in question, and #7 BYU is a double-digit favorite without its top running back.
Before either team kicks off, Florida State brings a star QB fresh off 5 rushing TDs to Louisville to face a Cardinals team that has lost three games by a field goal. Will both ranked teams survive on Friday night?
Don't wait until kickoff tonight — make your Friday college football picks on PrizePicks now. Just pick your players, choose More or Less on their stats, and earn real money if you're right. With Team Picks, you can make picks on game winners, spreads, and over/unders — now available in 36 states!
Keep it here with the Playbook for continued CFB picks, research, futures, and more all the way through the College Football Playoff.
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