The NFL’s Week 4 schedule continues on Sunday afternoon with four games in the late afternoon slate, including the Los Angeles Chargers vs. Seattle Seahawks, from Lumen Field in Seattle. For today's 4:25 p.m. ET kickoff, the Seahawks enter as 7.5-point favorites on the spread, per PrizePicks.
The Chargers are looking for their first win of the season after a surprising 0-3 start, while the Seahawks look to bounce back from their first loss of the season.
Below, we’ll break down our Chargers vs. Seahawks prediction and picks for Sunday’s NFL game, including the spread for PrizePicks.
Make your Chargers vs. Seahawks prediction and picks on PrizePicks now!
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Chargers vs. Seahawks Prediction, Spread, Over/Under - Sunday, October 4
One of the more surprising stories of the 2026 season has been the Los Angeles Chargers starting 0-3. The addition of Mike McDaniel as offensive coordinator to pair with QB Justin Herbert was viewed as one of the Chargers' most significant offseason moves, but it has not led to positive results.
The Chargers have lost all three games by a combined 32 points, the third-worst net margin in the NFL, only behind the Dolphins (-50) and Packers (-35).
The Los Angeles offense is near or at the bottom of every major category, per RBSDM.
- 31st in EPA/play (-0.177)
- 26th in success rate (40.8%)
- 28th in dropback EPA/play (-0.095)
- 30th in rush EPA/play (-0.302)
- 23rd in early-down EPA/play (-0.079)
- 29th in points per drive (1.29)
- 26th in turnover rate (17.7%)
- 32nd in third/fourth-down EPA/play (-0.525)
Through three games, Los Angeles is averaging 14.7 points per game, only ahead of the Titans, Dolphins, and Patriots. The only seasons in which the Chargers finished below 15.0 PPG were in 1975 (13.5) and 1973 (13.4). They won two games in both seasons.
The Seahawks' offense has had no such problems moving the ball, currently 10th in total yards (367.7) while ranking ninth in EPA/play (+0.053), points per drive (2.27), and success rate (46.8%). They have struggled running the ball, though, sitting 30th in rush EPA/play (-0.263), and rookie RB Jadarian Price was placed on injured reserve this week due to a chest injury.
On the defensive side, Seattle is allowing an NFL-low 3.83 yards per play. Further, the unit leads the in total defense (228.7 yards per game) and pass defense (141.7 yards per game). On the way to the Super Bowl title last year, the Seahawks were second in defensive yards per game play (4.45).
Since the NFL-AFL merger in 1970, only one team has started 0-4 and made the playoffs: the 1992 San Diego Chargers.
Chargers vs. Seahawks Spread, Over/Under – Sunday, October 4
The Seahawks enter Sunday’s game as 7.5-point favorites against the Chargers, returning a 1.26x payout on PrizePicks if they win outright.
Make your Chargers vs. Seahawks prediction on the spread on PrizePicks.
PrizePicks data is live at the time of writing and is subject to change.
Chargers vs. Seahawks Prediction on Spread – 10/4/26
Here are the key stats and trends behind our Chargers vs. Seahawks prediction on the spread for Sunday, October 4.
- The Chargers are one of six teams to start the season 0-3 vs. the spread, and their -13.7 cover margin is the worst in the NFL.
- Los Angeles has failed to cover six straight games dating back to last season. That is its longest such streak since 2020.
- Since 2013, only three teams have lost a game despite forcing 5 turnovers and finishing with a +4 turnover margin. The Chargers account for all three losses, including Week 3 against Buffalo.
- The Chargers produced a league-worst -23.89 offensive EPA in the fourth quarter. Through the first three quarters, they're 13th at -1.9.
- The Seahawks have allowed only 425 passing yards total through three games, the fewest in the NFL, with 4 INTs and a 76.2 passer rating allowed.
- Seattle's offense has the explosive-pass advantage. The Seahawks gain 10+ yards on 35.4% of pass plays (third). Meanwhile, L.A. allows 9.7 yards per target to wide receivers (sixth most), per Sharp Football.
Make your Chargers vs. Seahawks picks now for Sunday’s NFL game.
Chargers vs. Seahawks Picks, Player Stats for PrizePicks – 10/4/26
Here are the top Chargers vs. Seahawks picks to target on PrizePicks for Sunday, October 4. Today’s PrizePicks picks include QB Justin Herbert and WR Jaxon Smith-Njigba.
Chargers QB Justin Herbert vs. Seahawks: 199.5 Pass Yards
- Chargers QB Justin Herbert has failed to reach his passing projection in all three games this season, throwing for 192, 209, and 226 yards.
- Herbert's 199.5-yard projection is his lowest passing-yard projection since at least the start of the 2023 season. Across the 46 games since then, his average projection was 241.6 yards.
- Herbert’s QBR is 27.4, which is 31st in the NFL and only ahead of Giants QB Jameis Winston.
- The former first-round pick is 30th in EPA/play (-0.13).
Add Justin Herbert to your PrizePicks lineup now.
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Seahawks WR Jaxon Smith-Njigba vs. Chargers: 92.5 Receiving Yards
- Seahawks WR Jaxon Smith-Njigba has topped 120 receiving yards in all three games this season and leads the NFL with 405 yards (135.0 per game) and 6 receiving TDs. He's also tied for the lead with 27 receptions.
- The reigning NFL Offensive Player of the Year recorded a league-high nine 100-yard receiving games, two more than any other player. Plus, he led the league with 105.5 yards per game.
- JSN saw 10+ targets in 11 of 20 games last season and has 11+ in all three games this season.
- The Ohio State product also leads the NFL with a 37.9% target share after ranking first with a 35.8% total last year, per SumerSports.
Add Jaxon Smith-Njigba to your PrizePicks lineup now.
Make Chargers vs. Seahawks Picks on PrizePicks
Can the Chargers turn their season around instead of falling into a 0-4 hole? Meanwhile, the Seahawks look to bounce back from last week’s loss and keep pace with the 49ers in the NFC West.
Don't wait until kickoff — make your Chargers vs. Seahawks picks on PrizePicks now for Week 4 and earn real money if you're right.
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