The Cleveland Cavaliers (30-21) head west on Wednesday night to take on the Los Angeles Clippers (23-26) in an interconference showdown.
Cleveland looks to solidify its playoff positioning, while Los Angeles desperately searches for consistency. Tip-off is set for 10:30 p.m. ET on NBA League Pass.
Below, we’ll break down our Cavaliers vs. Magic prediction and spread for Wednesday night’s tilt. Make your picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals.
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Cavaliers vs. Clippers Prediction, Spread
The Cavaliers enter Wednesday's matchup with a solid 30-21 record, firmly in playoff contention in the Eastern Conference. Cleveland is adjusting to a blockbuster trade that sent G Darius Garland to the Clippers in exchange for G James Harden. Wednesday would mark Harden’s first trip back to Intuit Dome in a Cavaliers uniform, but both he and Garland are unlikely to suit up.
The Clippers, meanwhile, sit at 23-26 and badly need Garland’s backcourt energy to jump-start a disappointing season. L.A. has struggled with depth and consistency all year, sitting ninth in the West.
This marks the teams' second regular-season meeting, with the Clippers looking to even the score after a disappointing 120-105 loss back in November. The Cavaliers lead the all-time series 80–61.
Cavaliers vs. Clippers Over/Under, Spread
The Cavaliers enter Wednesday's game as 1.5-point road favorites, returning a 1.69x payout on PrizePicks Team Picks if they win outright.
The Clippers are home underdogs with a 2.08x payout if they win, via PrizePicks Team Picks.
- Spread: Cleveland Cavaliers -1.5
- Over/Under: 223.5
- Game Winner Payout: Cavaliers 1.69x | Clippers 2.08x
Team Picks data is live at the time of writing and is subject to change.
Cavaliers vs. Clippers Injury Report
Let’s dive into the full Cavaliers vs. Clippers injury report for Wednesday, via NBA.com.
Cavaliers Injury Report
- G James Harden (personal) – doubtful
- PF-C Evan Mobley (calf) – OUT
- SF Max Strus (foot) - OUT
Clippers Injury Report
- G Darius Garland (toe) - OUT
- G Bradley Beal (hip) - OUT
Cavaliers vs. Clippers Prediction on Spread
Here are some stats to know to help you make your Cavaliers vs. Clippers prediction on Wednesday, February 4.
- The Cavaliers are 20-31-0 against the spread (39.2%) this season, sitting near the bottom of the league.
- Los Angeles is 24-25-0 ATS (49.0%) and has failed to cover in two of its last three games.
- Despite their sub-.500 record, Los Angeles’ home (11-12-0 ATS) and away (13-13-0 ATS) marks have been virtually identical. Cleveland, on the other hand, has been inconsistent both at home (9-19-0 ATS) and on the road (11-12-0 ATS).
- Head coach Tyronn Lue’s Clippers carry a 116.0 defensive rating and allow 112.6 PPG, putting added pressure on their offense to outscore opponents.
- The Cavaliers have covered the spread in three of the last five meetings between these franchises.
Cavaliers vs. Clippers Picks for PrizePicks Today: Wednesday, February 4
Cavaliers G Donovan Mitchell vs. Clippers Projection: 29.5 Points
- Mitchell is averaging 28.8 PPG this season through 47 games with a 48.3% shooting percentage and 31.4% usage rate as Cleveland's undisputed primary option.
- The Clippers surrender 24.8 PPG along with 3.4 3-pointers made per game to opposing point guards.
- Spida has torched Los Angeles for 25.9 PPG across 20 career meetings, including 37 points on 63.6% shooting in their November 23, 2025, matchup at Rocket Mortgage FieldHouse.
- The Louisville product should still handle the workload on Wednesday night with Harden unlikely to make his debut with the new team.
Clippers SF Kawhi Leonard vs. Cavaliers Projection: 31 Pts+Asts
- Leonard is averaging 31.2 combined points and assists this season (27.6 PPG, 3.6 APG) through 36 games while posting a 32.0% usage rate that ranks ninth in the NBA, all but ensuring he'll shoulder the offensive load with James Harden now in Cleveland.
- The Cavaliers have a 113.6 defensive rating overall and have struggled defending elite wings, allowing 22.5 points and 3.8 assists per game.
- Leonard has dominated Cleveland for 29.5 PPG, 6.9 rebounds, and 2.9 assists across his last 10 meetings with the Cavaliers, including three 30+ point performances in his last five meetings.
- The added ball movement and pick-and-roll creation without Harden should generate cleaner looks and higher assist opportunities for Leonard as LA's primary scoring threat.
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