Buccaneers vs. Panthers Prediction, Spread, NFL Picks – Sunday, October 25

The NFL’s Week 7 slate continues Sunday with seven games at 1:00 p.m. ET, including the Tampa Bay Buccaneers at the Carolina Panthers at Bank of America Stadium in Charlotte. The Panthers enter as 2.5-point favorites on the spread, returning a 1.58x payout if they win. 

The Panthers enter as the NFC South leaders with a 3-2 record, 1.5 games ahead of the Falcons and Saints, while the Bucs have lost five of six to start the season and are in last place.

Below, we’ll break down our Buccaneers vs. Panthers prediction and picks for Sunday’s NFL game, including the spread.

Make your Buccaneers vs. Panthers prediction and picks on PrizePicks now!

{{nfl_offer_banner="/style-system/ui-components-playbook"}}

Buccaneers vs. Panthers Prediction, Spread, Over/Under - Sunday, October 25

The Panthers Sunday’s game as 2.5-point favorites against the Buccaneers, returning a 1.58x payout on PrizePicks if they win outright.

Here are the full payouts for the Buccaneers vs. Panthers game. PrizePicks data is live at the time of writing and is subject to change.

Make your Buccaneers vs. Panthers  prediction on the spread on PrizePicks.

The Buccaneers’ hopes of getting back in the NFC South race and saving their season got a boost this week with the return of QB Baker Mayfield. The franchise QB suffered a thumb injury in Week 3, with rookie Jalon Daniels starting the last three games. 

While they did win their only game of the season under Daniels, the offensive production dropped from nearly 21 points per game to 19.0, and passing yards dropped from 185.0 yards per game under Mayfield to 144.7 yards per game. Daniels also threw 5 INTs in his three starts, compared to Mayfield’s 2 INTs.

The offense became more run-dependent, which worked in the win over the Cowboys; Tampa Bay rushed for a season-high 241 yards vs. Dallas, but that also failed when the Bucs could not hold a lead over the Steelers last week. 

Like last year, the Panthers are atop the NFC South. Carolina held a share of the divisional lead from Week 13 last year and has had at least a share after all six weeks this season. 

QB Bryce Young is leading a Panthers offense that tops the NFL in passing and is second in total yards. His NFL-leading 309.8 yards per game are a notable improvement over last year’s 188.2. He's also produced 15 completions of at least 25 yards, the third-most in the league. 

The Panthers got to the top of the division with impressive wins over the Lions and Eagles. While the offense has been impressive, Carolina needs more consistency on the defensive side, entering the matchup last in rush yards allowed per play (5.12) and 25th in yards allowed (354.2). 

Carolina will be without edge rushers Jaelan Phillips and Thomas Incoom, but the Bucs are also missing WR Emeka Egbuka from their offense. 

{{nfl_offer_banner="/style-system/ui-components-playbook"}}

Buccaneers vs. Panthers Prediction on Spread – 10/25/26

Here are the key stats and trends behind our Buccaneers vs. Panthers prediction on the spread for Sunday, October 25.

• While the Panthers lead the league in passing, the Bucs defense is 19th against the pass, allowing 224.0 yards per game. We've seen Aaron Rodgers (253), Dak Prescott (316), Deshaun Watson (238), and Joe Burrow (254) all have successful days vs. the Bucs defense.  
• The Buccaneers rank 29th in offensive EPA/play, 25th in scoring, and 28th in red-zone efficiency. They have scored fewer than 20 points in four of their last five games.
• Not only are the Bucs 1-5 overall, but they are 1-5 ATS as well, only covering in the win at Dallas. 
• Tampa Bay has allowed 22 sacks in six games, an average of 3.7 per game. Its 9.1% sack rate sits 29th across the league.
• The Bucs are 22nd in turnover margin at -3, while the Panthers are ninth at +3. 
• Opponents have converted just 22.2% of third downs in the first half vs. the Buccaneers, but that jumps to 46.3% after halftime (19 for 41).

Lock in your Buccaneers vs. Panthers picks on PrizePicks now before kick-off!

Buccaneers vs. Panthers Picks, Player Stats for PrizePicks – 10/25/26

Here are the top Buccaneers vs. Panthers picks to target on PrizePicks for Sunday, October 25. Today’s PrizePicks picks include QB Baker Mayfield and QB Bryce Young.

Buccaneers QB Baker Mayfield vs. Panthers: 215.5 Pass Yards

• Before getting injured, Mayfield had gone over 215 passing yards in two of three games, at 216 and 217 passing yards. Last year, he failed to hit this number in six of his last eight games.
• In two games vs. the Panthers last year, Mayfield threw for 203 and 145 yards, going under his projection both times. 
• Over his last eight games, Mayfield has thrown at least 1 INT in seven of them.
• The Buccaneers will be without two key offensive starters Sunday, with WR Emeka Egbuka (concussion/foot) and RT Luke Goedeke (calf) ruled out.

Add Baker Mayfield to your PrizePicks lineup now.

Panthers QB Bryce Young vs. Buccaneers: 253.5 Pass Yards

• Bryce Young leads the NFL in passing yards per game (309.8) through Week 6 of the 2026 season. He has thrown for at least 280 yards in all five starts.
• Young has gone over his pass projection each appearance and in his last seven dating back to last season.  
• The former No. 1 overall pick is ninth with 0.217 EPA/play. 
• Young has gone over 260 passing yards in two of his last three games vs. the Buccaneers. 

Add Bryce Young to your PrizePicks lineup now.

{{gobbyandgobby_banner="/style-system/ui-components-playbook"}}

Make Buccaneers vs. Panthers Picks on PrizePicks

Can the Buccaneers turn their season around with the return of QB Baker Mayfield? Or will the Panthers take a stronger hold over the NFC South with a key divisional win?

Don't wait until kick-off — make your Buccaneers vs. Panthers picks on PrizePicks now for Week 7 and earn real money if you're right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.

Stay locked in on Playbook for daily NFL news, picks, analysis, and more all the way through Super Bowl LXI.