The 49ers (7-4) are coming off a 41–22 win over the division-rival Arizona Cardinals. They currently hold the NFC’s No. 7 seed and look to strengthen their playoff position on Monday night at home against the surging Carolina Panthers (6-5). The game kicks off at 8:15 p.m. ET on ESPN.
Brock Purdy made the most of his return after missing multiple weeks with an injury. In Week 11’s win over Arizona, he threw for 200 yards and 3 touchdowns, posted a 133.5 passer rating, and completed 73.1% of his passes. San Francisco will lean on him again as it tries to secure the final NFC playoff spot.
Below are the top Brock Purdy picks for Monday Night Football vs. the Panthers. There are ample PrizePicks NFL player projections to choose from.
Brock Purdy Stats, Pick vs. Panthers for MNF
Below are the top Brock Purdy picks for Monday Night Football vs. the Panthers. There are ample PrizePicks NFL player projections to choose from.
49ers QB Brock Purdy vs. Panthers Projection: 252.5 Pass Yards
- Purdy is averaging 262.0 passing YPG and has topped 252.5 yards in two of three games played this season.
- San Francisco averages 7.6 yards per pass attempt (seventh in NFL), and Purdy leads this offense with a 67.7% completion percentage and a 70.1 QBR.
- The Panthers’ defense has struggled against the pass in recent games. In their last three outings, they’ve surrendered 251.3 YPG, sixth most over that span.
- Carolina plays zone coverage on 82.3% of pass snaps (second most), and Purdy has been efficient when facing zone, completing 64.5% with an 86.8 passer rating and 71.0% catchable rate.
49ers QB Brock Purdy vs. Panthers Projection: 31.5 Pass Attempts
- The 49ers QB enters Week 12 with 99 pass attempts over three games, an average of 33.0 per start.
- San Francisco runs the 10th-most pass plays per game, and with mostly competitive game scripts (-0.53 game script), Purdy should be active early and often in this prime-time spot.
- The Niners rank 15th in average scoring margin (+0.8).
- Carolina faces 30.8 opponent pass attempts per game, including 31.7 over their last three.
- Opposing QBs had at least 32 passing attempts against the Panthers in five of their 11 games (45.5%).
49ers QB Brock Purdy vs. Panthers Projection: 19 Fantasy Score
- Purdy has averaged 19.2 fantasy points per game in 2025 and has cleared 19 points in two of his three starts.
- The Panthers allow 16.5 fantasy points per game to opposing QBs and have given up 20+ in five of their last eight outings.
- This matchup carries a 49.5-point total, and each of San Francisco’s last three games has featured at least 58 combined points, setting up shootout potential against Carolina.
- The former Iowa State Cyclone’s most recent MNF performance came in Week 17 of 2024, where he posted 377 yards and 3 TDs against Detroit.
More Brock Purdy Projections vs. Panthers on Monday Night Football
Here are some additional Brock Purdy projections vs. the Panthers on Monday Night Football, courtesy of PrizePicks.
- 67.9 Completion Percentage
- 1.5 Pass TDs (Goblin)
This 49ers-Panthers matchup presents plenty of MNF picks to consider — Purdy included — so check out the best projections and picks for the 49ers’ QB in Week 12.
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