Buffalo travels to Denver seeking consecutive road playoff wins for the first time since 1992. The Bills outlasted the Jaguars last Sunday, 27-24, behind QB Josh Allen’s go-ahead TD run with 1:04 remaining.
The top-seeded Broncos finished with their most wins (14) since 2015, the last time they hoisted the Vince Lombardi Trophy. Denver won eight of nine home contests and owns a spectacular 13-1 mark in the past 14 home outings.
Saturday's kickoff from Empower Field at Mile High is set for 4:30 p.m. ET on CBS. Let’s look at a Bills vs. Broncos spread prediction for Saturday’s AFC Divisional Round playoff game, weaving in PrizePicks Team Picks data to consider.
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Bills vs. Broncos Prediction, Spread, Over/Under
Buffalo eliminated Denver in last season’s Wild Card Round, 31-7, as 7.5-point home favorites. Now, the Bills make their first visit to see the Broncos since routing them 48-19 in 2020.
Bills vs. Broncos Over/Under, Spread
The Broncos enter this matchup as 2.5-point favorites, returning a 1.78x payout on PrizePicks Team Picks if they win outright.
The Bills are road underdogs with a 1.96x payout if they win, via PrizePicks Team Picks.
- Spread: Denver Broncos -2.5
- Over/Under: 47.5
- Game Winner Payout: Bills 1.96x | Broncos 1.78x
Team Picks data is live as of writing and is subject to change.
Bills vs. Broncos Prediction on Spread
Here are some stats to know to get you set for this afternoon, including insights on our Bills vs. Broncos spread prediction.
- The Bills improved to 5-4 against the spread on the road after last week’s victory. Buffalo defeated four division winners away from home (Jacksonville, New England, Pittsburgh, and Carolina).
- In spite of the best AFC record, the Broncos compiled a 7-10 ledger ATS.
- Denver allows the second-fewest yards (278.2) and second-fewest rushing yards per contest (91.1). Buffalo led the league in rushing yards per game (159.6) during the regular season.
- The Broncos went 11-2 in games decided by eight or fewer points. Their two losses to the Colts and Chargers came on walk-off field goals.
- Denver faced two playoff teams at home, beating Green Bay (34-26) and losing to Jacksonville (34-20).
- The Bills amassed a 3-1 mark against QBs ranked in the top 10 in passing yards (Patriots' Drake Maye twice, Jaguars' Trevor Lawrence, and Bucs' Baker Mayfield). Broncos QB Bo Nix is eighth with 3,931 yards.
- Denver won three of four games facing QBs in the top 10 of adjusted EPA per play. All three victories came at home against Green Bay, Dallas, and Kansas City.
- Buffalo has covered in four of the last five opportunities as an underdog, with the lone defeat coming to Kansas City in the 2024 AFC Championship Game.
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Make Bills vs. Broncos Divisional Round Picks on PrizePicks
The Bills hit the road for a second straight week to face the top-seeded Broncos in Saturday’s NFL Divisional Round opener. There’s never been a better time to add to the excitement of every NFL moment than with PrizePicks.
You can make your Bills vs. Broncos picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 30 states.
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