Will 12-5 Buffalo grab its first road playoff victory since 1992? The last time the Bills won away from home in the postseason was in the Sunshine State against the Dolphins. Now, they travel back to Florida to face the AFC South champion Jaguars (13-4) on Sunday.
Jacksonville put together a nine-win turnaround from 2024 in head coach Liam Coen’s first season, closing out with eight consecutive victories. Buffalo’s arch-nemesis (Kansas City) isn’t in the playoff field, and the Bills haven't lost in the Wild Card Round since 2019 at Houston.
Sunday's kickoff from EverBank stadium takes place at 1:00 p.m. ET on CBS. Let's dive into a Bills vs. Jaguars spread prediction for Wild Card Weekend, weaving in PrizePicks Team Picks data for the playoff bout.
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Bills vs. Jaguars Prediction, Spread, Over/Under
Jacksonville put together a strong 12-5 record against the spread during the regular season, while Buffalo compiled an 8-9 ATS mark.
Bills vs. Jaguars Over/Under, Spread
The Jaguars enter this matchup as 2.5-point favorites, returning a 1.85x payout on PrizePicks Team Picks if they win outright.
The Bills are road underdogs with a 1.92x payout if they win, via PrizePicks Team Picks.
- Spread: Jacksonville Jaguars -2.5
- Over/Under: 51.5
- Game Winner Payout: Bills 1.92x | Jaguars 1.85x
Team Picks data is live as of writing and is subject to change.
Bills vs. Jaguars Prediction on Spread for Wild Card Round
Here are some stats to know to get you set for Bills vs. Jaguars, including Wild Card Round insights on our Bills vs. Jaguars spread prediction.
- The Bills posted a 4-4 ATS away record, including losses at Miami and Atlanta. Buffalo also routed Pittsburgh and Carolina on the road, holding each team to fewer than 10 points.
- Since 2019, Buffalo owns a 7-6 playoff record, including five straight Wild Card Round victories.
- The Jaguars are riding an 8-0 ATS hot streak, with six of those covers being against non-playoff teams.
- Jacksonville’s most impressive victory was in Week 16, knocking off top-seed Denver on the road 34-20.
- The Bills won three of four road games against playoff squads, capped off by their incredible 35-31 comeback triumph at New England in Week 15.
- Jacksonville is 4-1 against QBs ranked in the top 10 in EPA per play. Buffalo star Josh Allen sits fourth in that category.
- In three home wins against playoff teams, the Jags allowed fewer than 10 points to the Panthers, Texans, and Chargers.
- Since losing in the 2017 AFC championship, Jacksonville has picked up a playoff victory, rallying past the Chargers on Wild Card Weekend in 2022.
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Make Bills vs. Jaguars Picks on PrizePicks
The Bills hit the road on Sunday to face the upstart Jaguars in perhaps the most intriguing matchup on Sunday’s NFL postseason card. There’s never been a better time to add to the excitement of every NFL moment than with PrizePicks.
You can make Bills vs. Jaguars Wild Card Weekend picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 30 states.
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