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What is NFLSZN on PrizePicks? Fantasy Football, Made Easy

May 17, 2025

May 17, 2025

Eagles RB Saquon Barkley (pictured) is a top fantasy football pick for 2025. You can play season-long fantasy football on PrizePicks with NFLSZN Lineups.

AP Photo/Abbie Parr

Think you know who’s popping off in the 2025 NFL season? NFLSZN on PrizePicks is the easiest way to win real money with your season-long NFL player player predictions. It’s similar to fantasy football, but without the drafts, waiver wires, and activating your Lineup.

It’s just you, your More or Less picks, and the full season of games to prove you know ball.

It’s simple: PrizePicks posts NFL players’ projected season-long stat totals on the NFLSZN board. You pick More or Less on those numbers for the full regular season. If you pick right, you win real money when the season ends.

It could be Patrick Mahomes 3,924.5 passing yards or Justin Jefferson nine receiving touchdowns — just pick your side, submit your Lineup, and let your squad ride through Week 18. See all of the NFLSZN projections to choose from here.

NFLSZN is like fantasy football — without all of the extra steps. We’ll explain how to play NFLSZN on PrizePicks below.

New to PrizePicks? Claim your $50 bonus when you sign up with promo code PLAYBOOK.

How to Play NFLSZN: Step-by-Step

Here’s how to play NFLSZN, PrizePicks’ season-long fantasy football game.

tl;dr – More or Less on player season-long stat projections, lock in your Lineup, and cash in after the NFL regular season if your picks are correct.

New to PrizePicks? Sign up and can claim $50 for free after your first $5 Lineup by using promo code PLAYBOOK.

  1. Pick your Players — Whether you’re going for breakouts or busts, you can pick anyone in your Lineup on the NFLSZN board. Pick between 2-6 players.
  2. Choose More or Less — From season-long passing yards to rushing yards, choose More or Less on a player projection, such as Derrick Henry’s 1,349.5 rushing yards.
  3. Submit your Lineup before Week 1 — Lock in your Lineup before the season starts.
  4. Track Your Lineup All Season — Once it’s submitted, find your NFLSZN Lineup in your My Lineups tab.
  5. Cash In — If your picks hit, you’ll win real cash when the season ends. 

That’s it! No setting Lineups in the season. No waiver wires. No injury panic. Just season-long conviction on your favorite players for the entire season.

What Stats are Available in NFLSZN?

The NFLSZN offerings runs deep. The closer we get to the season, the more stats will be added. Whether you’re a fantasy football die hard or just building your first Lineup, there’s a category for you. All stats account for season-long production.

  • Passing: yards, touchdowns, interceptions
  • Rushing: yards, touchdowns
  • Receiving: receptions, yards, touchdowns
  • Defense: Sacks, interceptions, total tackles

As we get closer to the start of the season, keep an eye out for even more specific stat types to hit the NFLSZN board.

Just pick More or Less on any stat type, pick at least players, and lock in your Lineup.

Note that only regular season stats count toward NFLSZN. Preseason and postseason production do not apply.

What Happens if My Player Gets Hurt in NFLSZN?

Every player must appear in at least five games to be eligible. If they don’t, they will be marked as DNP, and their pick is removed from your Lineup. Your payouts will be adjusted automatically — no penalty for getting unlucky.

For Combo squares that may appear closer to the season, both players must hit the 5-game minimum or they will be DNP’d.

This protects you from players who may suffer season-ending injuries early in the season.

Building an NFL SZN Lineup

Here are some basics for building your first NFLSZN, including Lineup types and some basic strategy tips.

NFLSZN Lineup Types

Just like in standard, daily PrizePicks Lineups, you’ve got two ways to play a Lineup:

  • Power Play — Higher payouts, but all picks must hit.
  • Flex Play — Lower payouts, but you can hit one (or two on 5-Pick and 6-Pick) and cash in.

Play with more risk, or with some cushion for misses — it’s your call.

NFLSZN Strategy & Tips

Here are some beginner’s tips for building your NFLSZN Lineups.

  • Check the schedule — not all schedules are created equal, some teams have it easier than others. Find 2025 strength of schedule rankings here.
  • Look for volume, not just talent — Volume and opportunity that you can count on goes a lot further than hype.
  • Spot the breakout… or the bust — NFLSZN is a perfect place for backing your sleeper or bust picks for the 2025 fantasy football season.
  • Beware of injuries — Although the injury policy accounts for players who miss most of the season, it’s still a good idea to be aware of aging player who are more injury prone.
  • Rookie beware — Rookies can be all the hype, but sometimes, their roles can be uncertain heading into the season.

This is a full-season fantasy football game. You’ll be tied to them all season. Don’t treat it like a one-week play.

Why Play NFLSZN on PrizePicks

Plain and simple, NFLSZN is the easiest way to get season-long actions on players you have strong takes on heading into the season. No activating every week, no waiver wires, no managing a team — just a few picks, and you can win real money.

  • Simplest way to get season-long action
  • No roster management
  • Built for cashing in on your takes
  • More flexible than other ways to get season-long action — pick who you want, any stats
  • Win real money with instant payouts
  • Perfect for the fantasy football-savvy who can’t spend weekly hours managing a team.

Build Your NFLSZN Lineup Today

Now that you’re in the know, it’s time to lock in your strongest takes on how the 2025 NFL season will play out. There’s no easier way to back them than with NFLSZN.

No drafts, no maintenance, no distractions — just your picks and a full season of games to prove that you knew ball.

Go to the NFLSZN board, find your edge, lock in your Lineups, and let the season play out exactly how you saw it coming.

Make your NFLSZN picks today and ride them through Week 18. New to PrizePicks? Claim your $50 bonus when you sign up with promo code PLAYBOOK.

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