NFL Week 3 Start ‘Em, Sit ‘Em WRs: Jameson Williams vs. Michael Wilson

September 24, 2026

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NFL
AP Photo/Ashley Landis
Arizona Cardinals WR Michael Wilson celebrates during an NFL game vs. the Houston Texans.

Fantasy managers might need help at WR for Week 3 with some key players dealing with injuries. Rams WR Puka Nacua (groin), Texans WR Nico Collins (hamstring), and Ravens WR Zay Flowers (hamstring) all missed Week 2 and might be forced to sit out at least one more game.

If adjustments need to be made, a couple of receivers stand out heading into the weekend.

Let’s look at a couple of healthy wideouts and break down our NFL Week 3 Start ‘Em, Sit ‘Em battle between Lions WR Jameson Williams and Cardinals WR Michael Wilson for your fantasy football picks this week, including PrizePicks projections for both players.

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Start ‘Em, Sit ‘Em WRs, Week 3: Jameson Williams vs. Michael Wilson?

Who'd be the better pick out of this NFL Week 3 Start 'Em, Sit 'Em dilemma: Williams or Wilson?

Why Start Jameson Williams?

Jameson Williams Week 3 PrizePicks Projections: 53.5 Rec Yards, 3 Recs, 11.5 Fantasy Score

  • Williams has disappointed with 6 receptions for 78 yards through two games. However, he's still run the sixth-most routes in the league among qualified WRs, per PFF.
  • The former first-round pick has an average depth of target of 13.8, which is higher than his mark of 12.7 yards last season when he averaged the third-most yards per reception (17.2) in the league.
  • Williams’ target share of 16.9% is not that far off from 2025 when it was 18.0%. He finished with 65 receptions for 1,117 yards, and 7 TDs on the year.
  • Lions QB Jared Goff generally performs better at home. Since joining Detroit, he's thrown 96 TDs at Ford Field compared to 59 TDs on the road.
Add Jameson Williams + Lions to win to your PrizePicks lineup now.

Why Start Michael Wilson?

Michael Wilson Week 3 PrizePicks Projections: 43.5 Rec Yards, 4 Recs, 10 Fantasy Score

  • Wilson has received 7 targets in both of the first two games of the season. According to RotoWire, he's accounted for 22.2% of the Cardinals’ targets and 34.8% of their air yards.
  • Former first-round WR Marvin Harrison Jr. has been used sparingly out of the gate, receiving a total of 4 targets entering Week 3.
  • In Week 2, Harrison logged 37 offensive snaps, compared to 47 offensive snaps for Wilson.
  • Although Wilson recorded just 2 receptions for 13 yards in Arizona’s 31-7 loss to the Seattle, the entire offense struggled with QB Jacoby Brissett only throwing for 95 yards, 1 TD, and 1 INT.
Add Michael Wilson + Cardinals to cover the spread to your PrizePicks lineup now.

Week 3 Start ‘Em, Sit ‘Em Verdict: Start Jameson Williams

Not only will Williams be at home on Sunday, but he also has a great matchup against the Jets. Last season, the Jets allowed the most passing TDs (36) in the league and were also last in dropback EPA/play allowed, according to RBSDM.

Not helping their cause for this game is that S Minkah Fitzpatrick (groin) could be out again after missing Week 2.

Wilson has a more difficult matchup against the 49ers, who have given up only 1 passing TD this year. They've also held opposing QBs to a 60.8% completion rate. It helped that they played Dolphins QB Malik Willis in Week 2, but they also performed well against Rams QB Matthew Stafford in Week 1.

In that contest, the reigning MVP was held to 155 yards, 0 TDs and 1 INT. He only completed 60.0% of his pass attempts.

Williams has a favorable matchup against a visiting Jets squad that's dealing with injuries and struggles to defend the pass even when healthy. Although Wilson seems to have surpassed Harrison in the pecking order, the 49ers' stout defense could leave him with a muted stat line for the second straight week.

That makes Williams the more appealing option for fantasy purposes.

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Williams has yet to have a breakout game, but he could put his first one on the board in Week 3 against the Jets. There will be plenty of weeks in which Wilson is a great fantasy option, but it’s difficult to feel better about him than Williams with a matchup against the 49ers on tap for Sunday.

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Mike Barner has been covering fantasy sports since 2007. He specializes in the NBA, NFL, and MLB. He is a two-time finalist for the Fantasy Sports Writers Association Basketball Writer of the Year award and won the 2021-22 FSGA NBA Experts Champions league. In addition to PrizePicks, Mike has written for Sports Illustrated, RotoWire, SportsLine, and more.