Tulane and Ole Miss, long-time rivals from neighboring states, square off for the second time this season. The first round game in the 12-team College Football Playoff kicks off Saturday afternoon in Oxford, Mississippi at 3:30 p.m. ET, and can be seen on TNT/HBO Max/truTV.
Below, we'll break down our Tulane vs. Ole Miss prediction and picks for the College Football Playoff, including the top player picks on PrizePicks' real money CFB game, including Tulane QB Jake Retzlaff, Ole Miss QB Trinidad Chambliss, and RB Kewan Lacy.
Tulane (11-2) finished the campaign tied with Navy and North Texas atop the American standings with a 7-1 conference record. The Green Wave beat North Texas, 34-21 in the American Conference Championship game to advance to their first College Football Playoff. Head Coach Jon Sumrall accepted the job at Florida, but will lead Tulane through the playoffs.
Ole Miss (11-1) set a school record for wins in a season, beating everyone on the schedule other than SEC champion Georgia. The Rebels finished in a four-way tie at 7-1 in the SEC, but lost the tie-breaker to play in the SEC title game. Coach Lane Kiffin left for LSU after the regular season finale against rival Mississippi State, and will be replaced by former Defensive Coordinator and new Head Coach Pete Goldin in the playoff.
The winner moves on to play third-ranked and SEC champion Georgia in the Sugar Bowl on January 1.
Let's get into our Tulane vs. Ole Miss prediction for Saturday afternoon's College Football Playoff matchup.
Tulane vs. Ole Miss Prediction, Spread, Over/Under
The Green Wave and Rebels meet for the second time this season, after Ole Miss prevailed 45-10 in Oxford on Sept. 22. Being from neighboring states, these teams are no strangers, having met 72 previous times, including earlier this season.
Ole Miss holds a 44-28 advantage in a series that kicked off in 1893. The teams played each other every year from 1950-65 while Tulane was in the SEC, and again from 1974-92.
Tulane vs. Ole Miss Over/Under, Spread
The sixth-ranked Rebels enter the first round CFP game 17.5-point home favorites, returning a 1.09x payout on PrizePicks Team Picks if they win.
The 11th-ranked Green Wave are the road underdog, with a 5.88x payout if they win, via PrizePicks Team Picks.
- Spread: Ole Miss -17.5
- Total: 56.5
- Game Winner Payout: Ole Miss 1.09x | Tulane 5.88x
Tulane vs. Ole Miss Prediction on Spread
Ole Miss is a 17.5-point favorite, the second-largest spread of any bowl game or CFP game this year, behind Oregon’s 21-pt spread over James Madison.
- Tulane is 6-6-1 against the spread this season, failing to cover five of the previous eight.
- The Green Wave are 2-1 against the spread as an underdog this season, winning outright vs. Memphis and North Texas (AAC title game) and failing to cover a 13.5 point spread against Ole Miss in their first meeting.
- Tulane averages 410.7 yards per game, 40th in the nation, while scoring 29.1 PPG, which is 57th. The Green Wave are both 55th in rushing and passing offense.
- On the defensive side, the Green Wave are 50th in scoring defense and 66th in total defense.
- Ole Miss has covered the spread in seven of 12 games this season. The Rebels covered in four of their first five games and have not covered in four of the last seven.
- The 17.5 points spread is the fourth-highest of the season. Ole Miss covered 33.5 vs. Georgia State, but failed to cover 51.5 (Won 49-0 over Citadel) or 33 (won 24-21 over Washington State).
- Ole Miss has the third-best offense in the nation, averaging 498.1 yards per game and the 11th-best scoring offense in the nation at 37.2 PPG.
Tulane vs. Ole Miss Picks for PrizePicks
Here are three Tulane vs. Ole Miss player picks for the first round College Football Playoff game for PrizePicks real money CFB game, including Tulane QB Jake Retzlaff, Ole Miss QB Trinidad Chambliss, and RB Kewan Lacy.
Pick More or Less on these projections on PrizePicks — plus thousands more — to win real money this CFB season.
Tulane QB Jake Retzlaff Projection vs. Ole Miss: 187.5 passing yards
- After reaching 225+ yards passing only once in his first four games of the campaign, Tulane QB Jake Retzlaff has thrown for 225+ in seven of his last nine games.
- Retzlaff is a dual threat QB, gaining 20+ yards on the ground in eight straight to start the season and in 10 of 13 overall.
- The junior's 16 rushing TDs are tied for most by any QB this season and is tied for fourth-most by any player on the ground here in 2025.
- In the September 22 meeting vs. Ole Miss, Retzlaff was held to career-lows in completions (5) and yards (56).
Ole Miss QB Trinidad Chambliss Projection vs. Tulane: 272.5 Pass Yards
- Ole Miss QB Trinidad Chambliss has passed for 250+ yards nine of his 10 starts this season, including seven games of 300+ yards.
- Chambliss is a dual threat, gaining 40+ yards on the ground in six of his 10 starts.
- The Swiss Army knife has a passer rating of 157.58, 17th in the nation and second in the SEC.
- The senior threw for 307 yards and 2 TDs and ran for 112 yards on 14 carries in the first matchup with Tulane back in September.
Ole Miss RB Kewan Lacy Projection vs. Tulane: 126 Rush Yards
- Ole Miss RB Kewan Lacy has 1,279 rushing yards this season, second-most in the SEC and ninth in the country.
- Lacy has 20 rushing TDs, which leads the SEC and is second in the nation.
- The shifty back dropped 65+ rushing yards in nine of the 12 games this season (68 vs. Tulane) and 100+ rushing yards in six of his 12, tied for seventh in the country.
- Lacy’s 106.6 rush yards per game is eighth in the country.
Make Tulane vs. Ole Miss Predictions on PrizePicks
Will Tulane continue its storybook season with an upset win over Ole Miss? Can the Rebels overcome the loss of Lane Kiffin and advance to the CFP quarterfinals for the first time? The winner moves on to play third-ranked and SEC champion Georgia in the Super Bowl on New Year’s Day.
The Tulane-Ole Miss first-round CFP game kicks off Saturday at 3:30 p.m. ET on TNT/HBO Max/truTV.
There are a wide variety of player stat projections on the CFB board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick your players, predict More or Less on their stats, and cash in on your predictions if you're right.
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