ESPN’s Wednesday doubleheader features four teams set to make the postseason — two in each conference. The late game at 9:30 p.m. ET focuses on the West, seeing the San Antonio Spurs host the visiting Portland Trail Blazers.
Despite having two of its best players banged up, this midweek bout has the Spurs listed as 4.5-point home favorites against the spread. Can the play-in bound Blazers pull off an upset in hostile territory?
Below, we’ll break down our Trail Blazers vs. Spurs prediction and picks for Wednesday night’s game. Make your NBA picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
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Trail Blazers vs. Spurs Prediction, Spread, Over/Under – Wednesday, April 8
It’s been a solid year for the Trail Blazers, who missed out on the play-in tournament by three games a season ago. Despite head coach Chauncey Billups being relieved of his duties early in this campaign, Portland has responded well to interim leader Tiago Splitter.
Entering Wednesday’s play, the Blazers are 40-39, one game back of the Los Angeles Clippers for the No. 8 seed and three games up on the Golden State Warriors for the No. 10 seed.
San Antonio has experienced some year-over-year growth of its own, albeit on a much grander scale. After winning just 34 games in 2024-25, head coach Mitch Johnson’s crew has 60 victories in 79 chances this year.
The Spurs are three games back of the reigning champion Oklahoma City Thunder, meaning they seem headed towards clinching the No. 3 seed in the Western Conference.
Portland and San Antonio have squared off 193 times in their regular-season history, with the series being close. The Spurs have a 99-94 edge, and the two sides have split their two meetings this season.
Trail Blazers vs. Spurs Spread, Over/Under
The Trail Blazers enter Wednesday’s game as 4.5-point road underdogs, returning a 2.27x payout on PrizePicks Team Picks if they win outright.
The Spurs are home favorites with a 1.58x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: San Antonio Spurs -4.5
- Over/Under: 230.5
- Game Winner Payout: Trail Blazers 2.27x | Spurs 1.58x
Team Picks data is live at the time of writing and is subject to change.
Trail Blazers vs. Spurs Injury Report for April 8, 2026
Let’s dive into the full Trail Blazers vs. Spurs injury report for Wednesday, April 8, via NBA.com.
Portland Trail Blazers Injury Report
- PF Jerami Grant (calf): OUT
- SG Vit Krejci (calf): Doubtful
San Antonio Spurs Injury Report
- G Stephon Castle (knee): OUT
- C Victor Wembanyama (rib): OUT
Trail Blazers vs. Spurs Prediction on Spread – 4/8/26
Here are the key stats to know before locking in your Trail Blazers vs. Spurs prediction on spread for Wednesday, April 8 on PrizePicks.
- The Spurs are 18-6-1 against the spread as home favorites this season, the eighth-best cover rate in the NBA. The Trail Blazers are 11-12 ATS as road underdogs.
- Portland’s offense generates the 15th-ranked scoring average at 115.6 points per game, yet it sits 22nd in points per shot (1.136) and 23rd in effective field goal percentage (53.4%).
- Defensively, the Blazers allow the sixth-most fastbreak PPG (16.6) and occupy the same ranking in first-quarter scoring allowance (30.6 PPG).
- The Spurs do a ton of damage inside the arc, sitting fourth in 2-point percentage (57.2%) and 11th in points in the paint (51.8 PPG).
- Anchored by MVP candidate C Victor Wembanyama, San Antonio’s defense is basketball’s third-best when it comes to points per shot (1.104) and eFG% (52.2%).
Trail Blazers vs. Spurs Player Picks for PrizePicks Today –4/8/26
Here are three top Trail Blazers vs. Spurs picks to target for Wednesday, April 8 on PrizePicks. Player picks via PrizePicks are headlined by SF Deni Avdija, PG Jrue Holiday, and PG De’Aaron Fox.
Trail Blazers SF Deni Avdija vs. Spurs Projection: 39.5 Pts + Rebs + Asts
- On the year, Avdija produces a combined 37.7 points, rebounds, and assists. Since the All-Star break, that number is down to 33.8.
- Avdija is in a terrible shooting slump, making just 43.0% of his shots and 19.1% of his 3-pointers since the start of February.
- The first-time All-Star’s 11.3% total rebounding rate is the lowest since an 11.0% mark in his rookie year with the Washington Wizards.
- Although the Spurs are without Wembanyama, their defense remains formidable. Per databallr, in 1,685 minutes with him off the floor this year, their defensive rating is 0.1 points per 100 possessions better than league average.
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Trail Blazers PG Jrue Holiday vs. Spurs Projection: 24.5 Pts + Asts
- Now in his 17th season, Holiday is experiencing a return to form in Portland, owning a per-game ledger of 22.6 points and assists.
- Holiday is playing 31.1 minutes per game in his last 10, posting 17.0 PPG and 6.2 APG.
- The veteran floor general’s 23.4% usage rate and 33.0% assist clip are his highest marks since 2022-23 with the Milwaukee Bucks, his last All-Star season.
- Holiday generates 19.1 potential assists per 100 possessions, placing him in the 99th percentile.
Spurs PG De’Aaron Fox vs. Trail Blazers Projection: 30.5 Pts + Rebs + Asts
- In 69 games this season, Fox puts together 28.2 PRA on average.
- In minutes without Wembanyama, Fox’s usage rate spikes by 7.4% and he scores 8.1 more points per 75 possessions.
- Swipa brings down 4.0% of his own misses, an 87th-percentile achievement.
- Via NBA RAPM, Fox spends 30% of his time on-ball and nets a career-best 2.4 potential assists per minute in those scenarios.
Make Trail Blazers vs. Spurs Picks on PrizePicks
Trail Blazers vs. Spurs picks for Wednesday night hoops aren’t the only avenue hoops fans have to getting in on the daily NBA action.
You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
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