The quarterback position will be front and center for the two Monday Night Football games for Week 6. Not only is there Bills star QB Josh Allen, but three promising young signal callers will be in action in Commanders QB Jayden Daniels, Bears QB Caleb Williams, and Falcons QB Michael Penix Jr.
Below, we'll discuss Allen and Daniels, and get into more of the top Week 6 Monday Night Football Picks for NFL DFS, including four player picks for PrizePicks.
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NFL DFS Week 6 Predictions, NFL Picks for Monday Night Football
Here are four of the top predictions and Week 6 Monday Night Football Picks for NFL DFS. Use this analysis to build your Lineups on PrizePicks NFL for Week 6 Monday Night Football.
Bills QB Josh Allen vs. Falcons Projection: 228.5 Pass Yards
- Allen threw for 252 yards, 2 TDs, and 1 interception in a Week 5 home loss to the Patriots.
- Although Allen has thrown for fewer than 215 yards in three of his five games, he has completed what would be a career-high 70.4% of his pass attempts.
- The reigning MVP has already seen his receivers drop 9 passes through five games. Last season, his receivers dropped just 16 passes over 17 games.
- The Falcons have allowed the fewest passing yards per game in the league, but they have had a favorable schedule. The last three quarterbacks that they have faced are Vikings QB J.J. McCarthy, Panthers QB Bryce Young, and Commanders QB Marcus Mariota.
Falcons QB Michael Penix Jr. vs. Bills Projection: 225.5 Pass Yards
- Before the Falcons had a bye in Week 5, Penix threw for 313 yards, 2 TDs, and 1 interception against the Commanders in Week 4.
- The second-year QB did not top 172 passing yards in either of his road games this season, but he has racked up at least 298 passing yards in both home games.
- Penix has tossed for at least 298 yards in three of his four career starts at home.
- The Bills are 30.6 points per game, the third-most in the NFL. If they keep their offense rolling in this game, the Falcons might be forced to throw a lot to try and keep pace.
Bears WR Rome Odunze vs. Commanders Projection: 66.5 Receiving Yards
- Odunze has received at least 7 targets in all four of his games this season.
- After having a 19.0% target share last season, the second-year pro has accounted for 26.7% of the Bears’ targets this season.
- The former Washington Husky continues to run deep routes, posting an average depth of target of 12.5 yards and getting 41.5% of the Bears’ air yards.
- The Commanders have allowed the tenth-most passing yards per game in the league.
Commanders RB Jacory Croskey-Merritt vs. Bears Projection: 68.5 Rush Yards
- Croskey-Merritt was given a season-high 14 carries against the Chargers last week. He turned them into 111 rushing yards and 2 TDs.
- The seventh-round pick in the 2025 Draft has received at least 10 carries in a game two times this season. In both of them, he finished with at least 82 rushing yards.
- According to RotoWire, Croskey-Merritt has a 27.9% broken tackle rate and is averaging 4.0 yards after contact.
- The Bears have given up 6.05 yards per carry to running backs, which is the highest mark in the NFL.
- Chicago has played four games this season and the leading rusher for their opponent has totaled at least 68 rushing yards in each of them.
- The Commanders will be thin at wide receiver with WR Terry McLaurin (quadriceps) and WR Noah Brown (groin) out. Commanders WR Deebo Samuel (heel) is also listed as questionable.
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Four talented quarterbacks will take the field for Monday Night Football in Week 6. Allen and Penix could both be in line for productive evenings when the Falcons host the Bills. In the nightcap between the Bears and Commanders, Odunze and Croskey-Merritt will have the potential to shine.
With the two upcoming Monday Night Football matchups, now is the time to build your NFL Lineup on PrizePicks. Just pick More or Less for at least two NFL player stat projections to build your Lineup on PrizePicks. Check out the Playbook for more NFL DFS picks and analysis all the way through the season.
