49ers RB Christian McCaffrey will be front and center for one of the marquee matchups of Week 10 when San Francisco hosts the Rams.
On the other end of the excitement spectrum is the matchup between the Jets and Browns, although both teams have bell-cow RBs in Breece Hall and Quinshon Judkins.
Below, we'll discuss McCaffrey, Hall, Judkins, and get into more of the top Week 10 NFL DFS picks for PrizePicks, including some quick picks to keep in mind.
Quick PrizePicks Picks for NFL Week 10
Here are some quick PrizePicks DFS picks for NFL Week 10, including projections for pass yards, rush yards, and receiving yards.
Jets QB Justin Fields vs. Browns Projection – 177.5 Pass Yards
- Justin Fields has thrown for fewer than 50 yards in three of his seven games.
- The Browns have allowed the fifth-fewest passing yards per game (182.6) in the league.
Cardinals RB Bam Knight vs. Seahawks Projection – 31.5 Rush Yards
- The return of Cardinals RB Emari Demercado resulted in Bam Knight receiving just 9 carries against the Cowboys in Week 9. He finished with 27 rushing yards.
- The former Jet and Lion is averaging only 3.4 yards per carry with Arizona.
Bills TE Dalton Kincaid vs. Dolphins Projection – 38.5 Receiving Yards
- Dalton Kincaid caught 5 of 6 targets for 66 yards and a TD vs. the Dolphins in Week 3.
- The Dolphins have allowed 8.90 yards per target to TEs, the fifth-highest mark in the league.
Top Week 10 NFL DFS Predictions, Picks for PrizePicks
Here are the top NFL DFS picks for Week 10. Player projections via the PrizePicks real-money NFL game.
49ers RB Christian McCaffrey vs. Rams Projection – 50.5 Receiving Yards
- In addition to rushing for 106 yards against the Giants in Week 9, McCaffrey caught 5 of his 6 targets for 67 yards and 1 TD.
- The superstar RB has received at least 6 targets in every game this season and has a 25.8% target share.
- With 61 receptions through nine games, McCaffrey is on pace to record at least 100 receptions in a season for the third time in his career.
- When the former first-round pick faced the Rams in Week 5, he caught 8 of 9 targets for 82 yards and 1 TD.
Dolphins WR Jaylen Waddle vs. Bills Projection – 63.5 Receiving Yards
- Jaylen Waddle caught 6 of 9 targets for 82 yards in a blowout loss to the Ravens in Week 9.
- Since WR Tyreek Hill went down, Waddle has posted at least 82 receiving yards in four of five games. During that span, he was targeted 36 times.
- The fifth-year receiver has an average depth of target of 11.3 yards, which is on pace to be the second-highest mark of his career.
- The Dolphins have allowed 27.0 points per game and the Bills have scored 29.4 points per game, so Miami might be forced to throw a lot in this matchup as their offense tries to keep pace.
Bears RB D’Andre Swift vs. Giants Projection – 55.5 Rush Yards
- D'Andre Swift is in line to return after sitting out Week 9 with a groin injury.
- Prior to being sidelined, Swift had recorded at least 100 rushing yards in two of his previous three games.
- The Giants have given up 5.89 yards per carry to RBs, which is the highest mark in the league.
- According to 4for4 Football, the Giants are tied for the highest explosive rush rate allowed (14.2%).
49ers TE George Kittle vs. Rams Projection – 4.5 Receptions
- George Kittle caught all 4 of his targets for 32 yards against the Giants in Week 9.
- The standout TE has been limited to four games this season because of injuries. He has not finished with more than 5 targets or 4 receptions in any of those matchups.
- Kittle has been targeted on just 16.7% of his routes run.
- The Rams have allowed just 39 receptions to TEs, the 10th-fewest in the NFL.
- Kittle has not posted at least 5 receptions in a game against the Rams since 2021.
Jets RB Breece Hall vs. Browns Projection – 64.5 Rush Yards
- The Jets traded away CB Sauce Gardner and DT Quinnen Williams on Tuesday, but held onto Hall and WR Garrett Wilson.
- Hall has finished with fewer than 60 rushing yards in four of his eight games.
- The Browns have permitted the fourth-fewest yards per carry to running backs (3.68).
- Cleveland has allowed only three RBs to rush for at least 65 yards against them.
Browns RB Quinshon Judkins vs. Jets Projection – 19.5 Rush Attempts
- Judkins dealt with a shoulder injury versus the Patriots in Week 8, but the Browns being on a bye last week has him healthy for this matchup with the Jets.
- Prior to getting banged up, the rookie had been given at least 20 carries in three of his previous four games.
- The Jets’ defensive line isn’t nearly as formidable with Williams no longer in the picture.
- The Browns might continue to rely heavily on their rushing attack based on the struggles of QB Dillon Gabriel, who has thrown for fewer than 200 yards in three of his four starts.
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McCaffrey could be poised for another big performance in the passing game when the 49ers take on the Rams in Week 10. Waddle also has the potential to rack up receiving yards, although a juicy stat line might not be in the cards for Kittle.
As far as RBs go, Judkins and Hall may finish with very contrasting stat lines when the Browns and Jets play each other.
With plenty of positions and projection categories to consider, now is the time to make NFL picks on PrizePicks. Just pick players, predict More or Less on their projected stats, and cash out if you're right.
Check out the Playbook for more NFL DFS picks and analysis all the way through the season.
