The San Francisco 49ers (10-4) turned the corner at the right time, seeking their fifth consecutive victory on Monday night.
The Niners travel to the Hoosier State to face the reeling Indianapolis Colts (8-6), who are in danger of missing the playoffs following a 7-1 start.
After losing QB Daniel Jones for the year ,the Colts brought back 44-year old signal caller Philip Rivers last week to start against the Seahawks. Rivers led Indianapolis to a 13-3 lead late in the first half before Seattle rallied for an 18-16 triumph.
San Francisco is facing its third straight AFC opponent, after crushing Cleveland (26-8) and trouncing Tennessee, 37-24.
Both teams sit in third place in their respective divisions, but San Francisco is the sixth seed in the NFC playoff hunt, while Indianapolis is the first team out of the AFC playoffs with three games remaining.
Let’s look at our MNF Picks for 49ers vs. Colts on PrizePicks for Monday night’s battle at Lucas Oil Stadium, kicking off at 8:15 p.m. ET on ESPN.
Top MNF Picks for 49ers vs. Colts on PrizePicks
San Francisco seeks its sixth cover in the past seven games, while Indianapolis is 4-1 against the spread as an underdog. The 49ers enter this matchup as 6.5-point favorites, returning a 1.36x payout on PrizePicks Team Picks if they win outright.
The Colts are home underdogs with a 2.94x payout if they win, via PrizePicks Team Picks.
- Spread: San Francisco 49ers -6.5
- Over/Under: 45.5
- Game Winner Payout: 49ers 1.36x | Colts 2.94x
Monday Night Football Picks for 49ers vs. Colts on PrizePicks
Here are three top 49ers vs. Colts picks to target on Monday. Key PrizePicks player projections are headlined by San Francisco QB Brock Purdy, Indianapolis RB Jonathan Taylor, and 49ers TE George Kittle.
49ers QB Brock Purdy vs. Colts Projection: 245.5 Yards
- The Mr. Irrelevant of the 2022 draft put together his best game of this injury-riddled campaign last Sunday against Tennessee, compiling 295 passing yards and 3 TD passes, while completing 76.7% of his attempts.
- The former Iowa State standout dropped more than 250 passing yards in three of six starts.
- The Colts rank 31st in the NFL in passing yards allowed per game (247.6). In the last four games, Indianapolis gave up at least 246 passing yards three times, with a low of 244 against Jacksonville in Week 14.
- Purdy averaged 240.3 yards in his six outings, compared to backup QB Mac Jones, who put up 268.8 yards per game in his eight starts.
Colts RB Jonathan Taylor vs. 49ers Projection: 98.5 Rushing Yards
- Taylor entered Week 16 sitting atop the rushing leaderboard with 1,443 yards. Buffalo RB James Cook jumped the Colts tailback and owns the top spot with 1,532 yards.
- Since torching the Falcons for 244 rushing yards in Week 10, the former Badger is averaging 76 yards in each of the past four outings.
- The sixth-year tailback bypassed 100 rushing yards in three home games and averaged 110.5 yards in six contests at Lucas Oil Stadium..
- The 49ers twice yielded at least 100 rushing yards to opposing running backs, each to AFC South foes. Jacksonville RB Travis Etienne Jr., put up 124 yards in Week 4, while Tennessee RB Tony Pollard finished with 104 yards last Sunday.
49ers TE George Kittle vs. Colts Projection: 67.5 Receiving Yards
- Kittle will fall short of his third consecutive 1,000-yard campaign, but is riding a solid five-game run.
- The former Iowa star managed 67 or more receiving yards in five consecutive contests, capped off by an 88-yard effort against the Titans last Sunday.
- Entering Week 16, the Colts gave up the fifth-most receiving yards to opposing tight ends (928).
- Kittle ranks 14th among tight ends with 7 receptions of at least 20+ yards. — in only nine games played.
Make Picks on NFL on PrizePicks
The 49ers are creeping closer towards a playoff berth and look to take advantage of a struggling Indianapolis squad on the road Monday night.
There’s never been a better time to add to the excitement of every NFL moment than with PrizePicks.
There is a wide variety of player stat projections on the NFL board, so you can build your Lineup however you’d like — with no salary or positional restrictions. Just pick at least two player stat projections to build your Lineup on PrizePicks.
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