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St. John’s vs. Seton Hall Prediction, Spread, College Basketball Picks – 3/6/26

St. John's Red Storm F Zuby Ejiofor attacks the rim against the Marquette Golden Eagles.
AP Photo/Aaron Gash

The St. John’s Red Storm (24-6) are one victory away from wrapping up the top seed in next week’s Big East tournament. Head coach Rick Pitino’s squad makes the short trip to Newark to face the Seton Hall Pirates (20-10).

Seton Hall is one of the most improved teams in the country after finishing last season with a dreadful 7-25 record. 

Let’s look at a St. John’s vs. Seton Hall prediction for Friday’s showdown at Prudential Center, tipping off at 9:00 p.m. ET on FS1. Make your CBB picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!

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St. John’s vs. Seton Hall Prediction, Spread, Over/Under

The Red Storm rallied from a 15-point second-half deficit to stun the Pirates at Madison Square Garden, 65-60, on January 26.

Seton Hall easily cashed as 10.5-point underdogs, marking the sixth cover in the past eight matchups.

Since Pitino took over St. John’s in 2023, the Red Storm own a 4-2 mark against the Pirates.

St. John’s vs. Seton Hall Spread, Over/Under

The Red Storm enter this matchup as 4.5-point favorites, returning a 1.47x payout on PrizePicks Team Picks if they win outright.

The Pirates are home underdogs with a 2.56x payout if they win, where you can earn money with your picks in 34 states.

  • Spread: St. John’s Red Storm -4.5
  • Over/Under: 137.5
  • Game Winner Payout: St. John’s 1.47x | Seton Hall 2.56x

Team Picks data is live as of writing and is subject to change.

St. John’s vs. Seton Hall Prediction on Spread

Here are some key stats to know before locking in your St. John’s vs. Seton Hall prediction on the spread for Friday, March 6 on PrizePicks.

  • In Big East play, the Johnnies have failed to cover in consecutive games only once.
  • The Red Storm have covered four straight games coming off an against-the-spread (ATS) loss.
  • In nine home conference games, the Pirates are 3-6 ATS.
  • The Red Storm rank third in Big East play in offensive efficiency but 10th in 2-point shooting (48.7%).
  • Seton Hall sits 11th in conference action in 2-point shooting (46.8%) and 3-point shooting (29%).
  • In each of Seton Hall’s last three losses, it has shot 40% or higher from long distance, but the Pirates hit fewer than 37% of their 3-point shots in each of their past four wins. 
  • St. John’s drilled the under in six straight games while holding each opponent to 72 or fewer points. 

St. John’s vs. Seton Hall Picks for PrizePicks Today: 3/6/26

Here are some top St. John’s vs. Seton Hall picks to target on Friday. Key PrizePicks player projections are headlined by three players: St. John's F Zuby Ejiofor, Seton Hall G A.J. Staton-McCray, and Pirates G Tajuan Simpkins.

St. John’s F Zuby Ejiofor vs. Seton Hall Projection: 22 Pts + Rebs

  • Following a four-game stretch of finishing below this projection, Ejiofor combined for 28 points and rebounds against Villanova and 30 points and boards against Georgetown.
  • Seton Hall stifled Ejiofor in the first matchup, limiting him to 9 points and 4 rebounds in 27 minutes.
  • He has not reached this projection in three consecutive road games, last topping 23 points and rebounds at DePaul on February 3.

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Seton Hall G A.J. Staton-McCray vs. St. John’s Projection: 13.5 Pts + Asts

  • In the first matchup against St. John’s, the senior scored 16 points and posted 1 assist in 34 minutes.
  • Staton-McCray hasn’t dished out more than 2 dimes in 16 of the last 17 games. 
  • His best scoring output in Big East play came against UConn, putting up 20 points in last Saturday’s four-point defeat.
  • Staton-McCray has finished above this projection in five of the past six contests.

Seton Hall G Tajuan Simpkins vs. St. John’s Projection: 9.5 Points

  • After averaging 14.6 points per game (PPG) at Elon last season, Simpkins is posting 10.3 PPG in his first go-around at Seton Hall.
  • The junior bounced back from two subpar efforts against Georgetown and UConn to put up 10 points in Tuesday’s win over Xavier.
  • Simpkins compiled 14 points in the first meeting with the Red Storm despite shooting 5-of-13 from the floor. 
  • He is looking for consecutive double-digit scoring outputs for the first time since late January. After scoring 14 points in back-to-back games, he dropped a season-high 27 points on Xavier on January 28.

Make #18 St. John’s vs. Seton Hall Picks on PrizePicks

The Red Storm seek the top seed in the Big East tournament for the second straight season. Can St. John’s wrap it up with a win, or might they get tripped up by an improved Seton Hall squad?

You can make your St. John’s vs. Seton Hall picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states

Check out the Playbook throughout the season for more CBB picks, predictions, and news every day.

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Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Kevin has spent the last 15 years in the sports gambling space. He covered all major sports at VegasInsider both as a writer and handicapper from 2009 until 2024. He has also covered college basketball and MLB for the Action Network.

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