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Spurs vs. Clippers Prediction, Spread, NBA Picks for Monday, March 16

San Antonio Spurs C Victor Wembanyama takes a shot during the second half of an NBA game.
AP Photo/Mike Christy

Tonight at the Intuit Dome, the San Antonio Spurs (49-18) face the L.A. Clippers (34-33) in a Western Conference matchup.

After the Spurs’ five-game winning streak was snapped by the Denver Nuggets, they rebounded with a win over the Charlotte Hornets. The Clippers just had their four-game winning streak snapped in an upset loss to the last-place Sacramento Kings. San Antonio is an 8.5-point favorite on the spread for tonight’s game at 10:00 p.m. ET on Peacock.

Below, we’ll break down our Spurs vs. Clippers prediction and picks for the Monday night game. Make your NBA picks on PrizePicks and earn real money if you’re right, including on game winners, spreads, and totals!

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Spurs vs. Clippers Prediction, Spread, Over/Under

The Spurs currently have a 7.5-game lead for the No. 2 seed in the Western Conference and are only 3.5 games behind the Oklahoma City Thunder for the top seed. They're one of the hottest teams in the league, winning 17 of their last 19.

What makes them a potentially dangerous team in the playoffs is how balanced this lineup is. San Antonio is one of two teams that ranks in the top five in both adjusted offensive and defensive ratings, according to Dunks & Threes.

C Victor Wembanyama is in the MVP conversation, leading the league with a +15.6 net rating (minimum 50 games played) and ranking fifth with 11.2 rebounds per game. 

The Clippers are one of the most remarkable stories this season. They've made history, becoming the first team to go over .500 after being 15 games below it.

L.A.’s defense is its strongest aspect during this run, ranking seventh in points allowed per game (109.6) and eighth in opponent field-goal percentage (46.1%) since December 19.

Even after trading star PG James Harden to the Cavaliers, they are still winning. That’s because they have SF Kawhi Leonard, who ranks sixth in PPG (28.3). Unfortunately, they could be without their All-Star for this matchup after leaving the loss to the Kings with a sprained ankle.

Spurs vs. Clippers Spread, Over/Under

The Clippers enter Monday’s game as 8.5-point home underdogs, returning a 4x payout on PrizePicks Team Picks if they win outright.

The Spurs are road favorites with a 1.23x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.

  • Spread: San Antonio Spurs -8.5
  • Over/Under: 226.5
  • Game Winner Payout: Spurs 1.23x | Clippers 4x

Team Picks data is live at the time of writing and is subject to change.


Spurs vs. Clippers Prediction on Spread – 3/16/26

Here are the key stats to know before locking in your Spurs vs. Clippers prediction on spread for Monday, March 16 on PrizePicks.

  • The Spurs rank fourth in the league, averaging 118.8 PPG.
  • The Clippers are excellent beyond the arc, ranking 10th with a 36.3% 3-point shooting clip.
  • San Antonio is a reliable team on the road with an 18-14-1 record against the spread.
  • Following a loss, LA is 15-17 ATS.
  • The Spurs tend to play lower-scoring games on the road, with 20 of 33 their games going under the listed total.

Spurs vs. Clippers Injury Report

Let’s dive into the full Spurs vs. Clippers injury report for Monday, via NBA.com.

San Antonio Spurs Injury Report 

  • G Dylan Harper (calf): OUT
  • C Luke Kornet (knee): OUT

Los Angeles Clippers Injury Report

  • SF Kawhi Leonard (ankle): Doubtful

Spurs vs. Clippers Picks for PrizePicks Today: 3/16/26

Here are the top Spurs vs. Clippers picks to target for Monday, March 16. Spurs C Victor Wembanyama and Clippers PG Darius Garland headline today’s NBA projections for PrizePicks.

Spurs C Victor Wembanyama Projection vs. Clippers: 37.5 Pts + Rebs

  • In the previous match against the Clippers on March 6, Wembanyama led the team with 27 points and 10 rebounds.
  • The Alien has exceeded 39 combined points and rebounds in 9 of his last 14 games.
  • The Clippers give up an average of 27.9 points to the C position over their seven games.

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Clippers PG Darius Garland Projection vs. Spurs: 26.5 Pts + Ast

  • With Leonard potentially not in the lineup, Garland could control the Los Angeles offense.
  • Since making his Clippers debut on March 2, the former Cavaliers guard has led the team with 6.0 assists per game.
  • The seven-year veteran has exceeded 26 points and assists in four straight games.

Make Spurs vs. Clippers Picks on PrizePicks

The Clippers and Spurs are competing for seeding, making every contest that much more important during the final stretch of the regular season.

You can make your Spurs vs. Clippers picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states

Stick around with the Playbook for continued NBA predictions, picks, and news every day until the 2026 NBA Finals.

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Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

John is a graduate from Quinnipiac University with a Master’s Degree in Sports Journalism. With almost 15 years working in radio, TV and blogs, it includes stops at ESPN, NBC Sports, and Audacy. Along with being an avid sports fan, he is into fitness and cooking.

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