There’s a ton on the line in terms of playoff implications in Week 18 when the 49ers (12-4) host the Seahawks (13-3).
The winner of Saturday’s contest (8:00 p.m. ET on ABC/ESPN) will earn the NFC West division title and clinch the No. 1 seed in the NFC playoffs. In addition, the game’s victor earns a bye in the opening round of the postseason. The Seahawks came away with a narrow 17-13 win vs. the 49ers when the two teams faced off way back in Week 1.
Below, we will use PrizePicks Team Picks to make a Seahawks vs. 49ers spread prediction for the pivotal Week 18 contest and point out some key trends to consider.
Seahawks vs. 49ers Prediction, Spread, Over/Under
The Seahawks enter Week 18 as 2.5-point road favorites, returning a 1.66x payout on PrizePicks Team Picks if they win outright.
The 49ers are home underdogs with a 2.12x payout if they win, via PrizePicks Team Picks.
- Spread: Seattle Seahawks -2.5
- Over/Under: 46.5
- Game Winner Payout: Seahawks 1.66x | 49ers 2.12x
Team Picks data is live at the time of writing and is subject to change.
Seahawks vs. 49ers Spread Pick for Week 18
Here are some stats to keep in mind for Seahawks vs. 49ers, including a spread prediction for Week 18’s game using PrizePicks Team Picks.
- In 2025, the 49ers are 3-3-1 against the spread at home. Meanwhile, San Francisco has a 1-1 record ATS as a home underdog.
- The Seahawks are 5-1 ATS as a road favorite this season.
- Seattle is tied for a league-best 11-5 record ATS, while San Francisco isn’t too far behind with a 10-5-1 mark.
- Per Jefe’s Handiwork, San Francisco boasts a 49.0% overall success rate, which is second among NFL teams. Additionally, the 49ers rank first with a 55.9% late down success rate.
- Turnovers could be where this NFC West showdown is decided. The Seahawks had recorded 24 takeaways, which is tied for fourth in the NFL. The 49ers rank 23rd in that department with only 16 forced turnovers.
- Both teams rely heavily on their passing attacks to put points on the board. The 49ers are fourth with 252.3 passing yards per game, while the Seahawks tally 231.0 per contest (eighth).
Make Seahawks vs. 49ers Picks on PrizePicks
When Seattle and San Francisco do battle on Saturday with the NFC's top seed up for grabs, there will be several opportunities to make the most of player projections and much more in this prime-time affair.
You can make Seahawks vs. 49ers picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 30 states.
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