The top seed in the NFC playoff picture is up for grabs in Seattle tonight as the Seahawks host the Rams.
Both teams enter with identical 11-3 records and are tied for first place in the NFC West. Los Angeles already captured the first matchup with Seattle at home, 21-19 in Week 11. The Rams picked off Seahawks QB Sam Darnold 4 times and won in spite of being outgained, 414-249.
Los Angeles topped the 40-point mark for the second straight game in last Sunday’s 41-34 triumph over Detroit. The Rams overcame a 24-14 deficit to outscore the Lions, 27-10 down the stretch.
The Seahawks have won four straight games since losing at SoFi Stadium, capped off by last Sunday's 18-16 close-shave victory over the Colts.
The Rams will likely be without WR Davante Adams, who is doubtful with a hamstring injury.
Let’s look at the Rams vs. Seahawks picks for Thursday night’s showdown at Lumen Field, kicking off at 8:15 p.m. ET on Amazon Prime.
Rams vs. Seahawks TNF Picks Tonight: Week 16
Both the Rams and Seahawks own 10-4 records against the spread. The Seahawks enter this matchup as 2.5-point favorites, returning a 2x payout on PrizePicks Team Picks if they win outright.
The Rams are road underdogs with a 1.72x payout if they win, via PrizePicks Team Picks.
- Spread: Seattle Seahawks -2.5
- Over/Under: 41.5
- Game Winner Payout: Rams 2x | Seahawks 1.72x
Rams vs. Seahawks Picks & NFL DFS
Here are three top Rams vs. Seahawks picks to target on Thursday. Key PrizePicks player projections are headlined by Los Angeles QB Matthew Stafford, Seattle WR Jaxon Smith-Njigba, and Rams RB Kyren Williams.
Rams QB Matthew Stafford vs. Seahawks Projection: 230.5 Yards
- Stafford continues to post terrific numbers in his 17th season, throwing for 3,722 yards and 37 TDs.
- In last Sunday’s shootout victory over Detroit, the 2009 top pick torched his former team for 368 passing yards, his third performance of 300+ yards.
- The borderline Hall of Famer's worst passing output came in the Week 11 win over Seattle. He was limited to a season-low 15 completions and 130 yards.
- In his past three road games, the former Georgia star topped the 243-yard mark, capped off by a 281-yard outing against Arizona in Week 14.
- According to PFF, Stafford is the highest-ranked QB in overall grade (93.3) and passing grade (93.0).
Seahawks WR Jaxon Smith-Njigba vs. Rams Projection: 89.5 Receiving Yards
- JSN leads the league with 1,541 receiving yards, owning a 174-yard advantage over Rams WR Puka Nacua.
- The former Ohio State standout is off his ninth 100-yard receiving performance of the campaign, lighting up the Colts for 113 yards last Sunday.
- Smith-Njigba had his way in the first matchup against Los Angeles, hauling in 105 yards on 9 receptions. In last season’s home loss to the Rams, he put up a career-high 180 receiving yards.
- Not many teams have been able to slow down JSN, although the Rams are the highest-graded team for defensive coverage against wide receivers at PFF.
Rams RB Kyren Williams vs. Seahawks Projection: 55.5 Rushing Yards
- Williams reached 1,000 rushing yards for the third time in his career after last Sunday’s 78-yard outing against the Lions.
- The former Notre Dame tailback has eclipsed 56 rushing yards in six of the last seven games.
- The 2022 fifth-round selection has finished below 50 rushing yards once, getting held to 46 yards in the Week 12 home blowout of the Buccaneers.
- Williams put together his best yards per carry performance of 2025 against Seattle, racking up a 7.6 average along with 91 yards and a TD.
Make Picks on NFL on PrizePicks
The Seahawks look to avenge the close loss in the first matchup to the Rams as the NFC West rivals meet in Seattle tonight.
There’s never been a better time to add to the excitement of every NFL moment than with PrizePicks.
There is a wide variety of player stat projections on the NFL board, so you can build your Lineup however you’d like — with no salary or positional restrictions. Just pick at least two player stat projections to build your Lineup on PrizePicks.
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