Something's gotta give.
Week 3 brings us a battle of the unbeatens, a tussle between two NFC division leaders that boast legitimate Super Bowl hopes, pitting the reigning NFL champion Philadelphia Eagles against the Los Angeles Rams.
The early-slate bout (1:00 p.m. ET, FOX) contains plenty of star power, highlighted by the Rams’ red-hot duo of QB Matthew Stafford and WR Puka Nacua, and Philly's All-Pro RB, Saquon Barkley.
Below, we’ll go over our Rams vs. Eagles prediction and picks for PrizePicks NFL DFS to target. Make your Week 3 predictions with PrizePicks for a shot to win real money when you're right!
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Rams vs. Eagles Prediction, Preview for 9/21/25
- The Eagles lead the all-time series 25-20-1 against the Rams, and recent history is on their side, with the Birds holding an 11-4 record.
- That dominance is defined by a three-game winning streak and nine victories in the last 10.
- L.A. head coach Sean McVay is 1-5 against Philadelphia, including a defeat in January’s NFC divisional round of the playoffs.
Los Angeles Rams Preview
- After posting consecutive 10-7 seasons, the Rams are off to a sparkling 2-0 start. Their +19 point differential ranks fifth in the NFL entering Week 3.
- In conjunction with their offensive firepower, much of L.A.'s success stems from the top scoring defense.
- Rams coach Sean McVay and his troops won a 14-9 bout against the Texans in Week 1, then took out the rebuilding Tennessee Titans 33-19 in Week 2.
Philadelphia Eagles Preview
- Philly’s played a couple of nail-biters, winning 24-20 against the division rival Dallas Cowboys in Week 1, then escaping Kansas City with a 20-17 triumph in last Sunday's rematch of Super Bowl LIX.
- As September rolls on, the Eagles are still looking for their wings. According to SumerSports, they rank 15th in EPA per play on offense and 11th on defense.
- QB Jalen Hurts has managed just 253 passing yards. A whopping 30 other signal callers have more yards through two games.
Rams vs. Eagles Same Game Picks for NFL DFS & PrizePicks
Below are three of the top Rams vs. Eagles NFL DFS same game picks to consider for Week 3. The Sunday meeting is headlined by PrizePicks player projections for Matthew Stafford, Puka Nacua, and Saquon Barkley.
Rams QB Matthew Stafford Projection: 225.5 Pass Yards
- Stafford is on fire, averaging 271.5 passing yards. That would be his highest since 2021, his debut campaign with the Rams (287.4 yards).
- He boasts a stunning 7-for-9 clip on deep throws. Per Pro Football Focus' tracking, both incompletions were drops.
- In seven career outings against the Eagles, Stafford averages 235 yards per game, his second-lowest figure versus any NFL team.
- Philadelphia has allowed the eighth-fewest passing yards in the league this season.
Rams WR Puka Nacua Projection: 78.5 Receiving Yards
- Heading into Week 3’s play, Nacua leads all receivers in receptions with 18. He’s coming off an 8-catch, 91-yard outing in Nashville.
- Nacua continues to be a cheat code after the catch, posting +27 yards after reception versus expectation. He’s doing so despite playing just 66% of available snaps.
- The BYU product has faced the Eagles twice, averaging 94 receiving yards.
- The Rams’ signing of Davante Adams seems to have provided Nacua a near-perfect stylistic complement on offense.
Eagles RB Saquon Barkley Projection: 88.5 Rush Yards
- After leading the NFL in rushing yards in 2024, it’s been more of a slow burn for Barkley here in '25, as he's racked up just 74 rushing yards per game.
- Barkley was historically dominant last year against the Rams. In two meetings, he racked up a jaw-dropping 460 rushing yards and 4 TDs. He logged 26 carries in both games.
- Per StatMuse, only Derrick Henry boasts more 200-yard outings against a single team.
Make Rams vs. Eagles Picks on PrizePicks
Along with the Philly/L.A. rumble, Week 3 of the 2025-26 campaign brings ample opportunities to enjoy the action, as well as get in on some NFL DFS picks with PrizePicks.
Doing so is easy, whether you’re making Rams vs. Eagles picks or predicting another game. Simply choose your players, select More or Less for their stats, and call your shot by adding picks to your Lineup.
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