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PrizePicks MLB Cheat Sheet: MLB DFS Picks for Tuesday, June 3

Astros SP Lance McCullers is a top MLB DFS pick for Tuesday, June 3, in the PrizePicks MLB Cheat Sheet.
AP Photo/Karen Warren

The 2025 MLB season has had it all so far, and we’re only in June. From MVP battles this weekend between Shohei Ohtani and Aaron Judge, to a Rockies team that could go down as the worst team in baseball history, now sitting at 10-50 — things are heating up in MLB.

With a loaded 15-game slate and  new series starting on Tuesday, we’ll give you the best MLB DFS picks today, including pitchers and hitters for June 3 in the PrizePicks MLB Cheat Sheet.

Highlighting Tuesday’s games is a rematch of last year’s ALCS as the Cleveland Guardians (32-26) travel to the Bronx to face the New York Yankees (36-22) at 7:05 p.m. ET. With Taco Tuesday discounts on the PrizePicks board today, it’s that much easier to cash in on MLB today.

Whether you are targeting Hits+Runs+RBIs or pitcher strikeout projections, there are plenty of ways to win real money on PrizePicks with your MLB predictions. Below, we’ll give you some MLB DFS picks and analysis to help you craft your Lineup today.

MLB DFS Picks & Projections: Tuesday, June 3

Here are four of the top MLB DFS picks and projections to target on PrizePicks today. Use this analysis to help you build your MLB lineup on PrizePicks on Tuesday, June 3. Click each pick to read more.

Astros P Lance McCullers Jr. – 5 Pitcher Strikeouts

Houston Astros vs. Pittsburgh Pirates – 6:40 p.m. ET

MLB DFS Picks for June 3 - Lance McCullers Jr.
  • The Pittsburgh Pirates’ offense has been abysmal this season, hitting just .227 on the year with the sixth-most strikeouts in baseball.
  • Against right-handed pitchers, the Pirates are only hitting .229 on the year with a 25% strikeout percentage.
  • Astros SP Lance McCullers Jr. dominates against left-handed batters, allowing just a .158 batting average and striking out left-handed batters 47% of the time.
  • McCullers Jr. is projected to face five left-handed batters in the Pirates’ lineup – three left-handers, two switch hitters.

Guardians C David Fry – 0.5 Hits

Cleveland Guardians vs. New York Yankees –  7:05 p.m. ET

MLB DFS Picks for June 3 - David Fry
  • Guardians C David Fry got his first at-bat this season after his elbow surgery this offseason and struck out in his only plate appearance in the game.
  • Yankees SP Carlos Rodon has been electric this season, allowing just a .164 opposing batting average and striking out 90 batters in 72.2 innings pitched.
  • Against right-handed batters, Rodon allows just a .153 batting average and has a strikeout percentage of 35% this season.

Braves P Spencer Strider – 6.5 Strikeouts

Arizona Diamondbacks vs. Atlanta Braves – 7:15 p.m. ET

MLB DFS Picks for June 3 - Spencer Strider
  • The Arizona Diamondbacks remain one of the most disciplined teams at the plate this season, ranking fourth in strikeouts with only 439, and eighth in batting average (.254).
  • Braves SP Spencer Strider has struggled in his starts this season since his injury. Through 14 innings, he has allowed seven runs and struck out 15 batters — a significant drop from his 12.0 K/9 in 2024.
  • Although Strider seems to have the upper-hand against right-handed batters, allowing just a .217 batting average, he is projected to face only four right-handed batters in the Diamondbacks’ lineup as they have four switch hitters.
  • Strider’s pitch velocity has also dramatically decreased. His fast ball is down 2.5 mph from 2022 (1.4 from last year), and his slider has dropped 1.5 mph since last year.

Rays CF Kameron Misner – 0.5 Hits

Texas Rangers vs. Tampa Bay Rays – 7:35 p.m. ET

MLB DFS Picks for June 3 - Kameron Misner
  • Although he started off the season hitting nearly .400, Rays OF Kameron Misner has struggled over the last month. He has managed just 11 hits since the start of May, which has dropped his batting average to .224.
  • Although he is hitting .254 against right-handed pitchers, Misner has managed to strikeout nearly 32% of the time.
  • Rangers SP Tyler Mahle has great results this year, giving up a career-best .232 BABIP  and .192 batting average through 66 innings pitched.
  • Against left-handed batters like Misner, Mahle is allowing a .158 average and has a strikeout rate of nearly 26%.

Make Your MLB DFS Picks on PrizePicks

With the NHL and NBA Playoffs wrapping up, there is no better time to lock in on MLB DFS on PrizePicks. Each day brings more opportunities, especially on a day like Tuesday, where every team is taking the field.

Build your MLB Lineup on PrizePicks with your favorite MLB projections and win real money if your picks are correct. All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — to win.

Stay locked in on the Playbook all season long for MLB DFS picks every day.

Get in the Game! Sign up for PrizePicks and win real money with your picks. Play $5 to get $50 free with promo code PLAYBOOK.

about the author

Austin Wells is a social media manager and content strategist. He’s from Covington, Georgia, and graduated in 2024 with a degree in Business Administration, concentration in marketing. Austin loves all things Philadelphia, including the Eagles and the Sixers, but his MLB fandom lies with the Yankees. He collects baseball cards and has the ultimate goal of visiting every MLB and NFL stadium.

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