The Boston Celtics (26-16) face the Indiana Pacers (10-34) at TD Garden on Wednesday, aiming to maintain their strong position in the Eastern Conference despite the ongoing absence of Jayson Tatum. Tip-off is set for 7:30 p.m. ET.
Below, we'll preview the game and break down two of the top Pacers vs. Celtics NBA Picks on PrizePicks for today, including for PF Pascal Siakam and SG-SF Jaylen Brown.
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Pacers vs. Celtics Prediction, Spread, Over/Under
Many entered the 2025-26 season down on the Celtics, as Jayson Tatum is still dealing with the Achilles injury he suffered during last year’s playoffs. His rehab is going well, and there’s a good chance he’ll suit up again this year.
Even without Tatum, PG Jrue Holiday or C Kristaps Porzingis, Jaylen Brown has done just fine leading the team in his place.
The former Cal Golden Bear is averaging career highs in points (29.7), rebounds (6.6), and assists (4.7), while helping anchor one of the NBA’s best defenses. He’s proving that he’s capable of being the focal point for a contender with support from PG Payton Pritchard, G Derrick White, and the newly-acquired G Anfernee Simons.
Pritchard (16.6) and White (17.7) are averaging career highs in points per game as secondary and tertiary scorers. Boston still has a hard-nosed mentality on defense, and its edge will make things tough for an Indiana team that’s struggled without its leader.
The Pacers have looked like a completely different team since they lost Haliburton to an Achilles injury in the 2025 NBA Finals. Their offense is averaging just 110.1 points per game, but they've done a great job limiting opposing teams from beyond the arc and at the free-throw line on defense.
Indiana's opponents are making a league-low 11.4 3-pointers per game, and only the Dallas Mavericks are holding opponents to a lower shooting percentage (34.1%) from beyond the arc. The Celtics are attempting (42.7) and making (15.7) the second-most triples in the league per game, so the Pacers' perimeter defense will likely be crucial in this matchup.
Pacers vs. Celtics Over/Under, Spread
The Celtics are 10.5-point favorites, returning a 1.19x payout on PrizePicks Team Picks if they win outright.
The Pacers will return a 4.34x payout on PrizePicks Team Picks if they win outright.
- Spread: Celtics -10.5
- Over/Under: 227.5
- Gamer Winner Payout: Pacers 4.34x | Celtics 1.19x
(Team picks data is live as of publishing and is subject to change.)
Pacers vs. Celtics Injury Report
Let’s dive into the full Raptors vs. Warriors injury report for Tuesday, via NBA.com.
Pacers Injury Report
- G-F Jaylen Brown (hamstring) – probable
- PF Josh Minnott (ankle) – OUT
Celtics Injury Report
- SG Bennedict Mathurin – OUT
Pacers vs. Celtics Prediction on Spread
Here are some stats to know to help you make your Pacers vs. Celtics prediction against the spread today on PrizePicks Team Picks.
- The Celtics boast the league’s second-ranked scoring defense, while the Pacers have the second-worst scoring offense.
- Indiana has gone 4-10 against the spread in its previous 10 road games.
- Only three teams have covered more times (14) than Boston on one day of rest this season.
- The Celtics rank third in point differential (+6.7), while the Pacers rank 28th (-8.2).
Pacers vs. Celtics Picks, Stats for PrizePicks Today
Here are two of the top Pacers vs. Celtics picks on PrizePicks Player Picks for today. Player projections via the PrizePicks real money NBA game.
Pacers PF Pascal Siakam vs. Celtics Projection: 10.5 Rebs+Asts
- Siakam averaged 13.5 Pts+Asts over his previous six games.
- According to databallr, the Pacers swingman is generating 11.4 potential assists per 100 possessions in 2026.
- The New Mexico State product has hauled in at least 102 more rebounds than any other Indiana player this season.
- The three-time All-Star averages 11.1 Pts+Rebs against the Celtics through seven games against them as a Pacer.
Celtics SG-SF Jaylen Brown vs. Pacers: 24.5 Points
- Brown is on track to average more than 30.0 points per game for a second consecutive month.
- Only Luka Doncic can top Brown’s usage rate (36.2) this season.
- The Cal product is hoisting up a season-high 25.4 field goal attempts this month.
- The 2024 NBA Finals MVP leads the league in field goal attempts per 100 possessions (32.9) and per 36 minutes (23.6), according to basketball reference.
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Make Pacers vs. Celtics Picks on PrizePicks
With long-term injuries plaguing both Boston and Indiana, Jaylen Brown and Pascal Siakam have been asked to step into larger roles in 2025-26. Both players worth watching in Wednesday’s game at TD Garden in Boston.
You can make Pacers vs. Celtics picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 30 states.
Stick around with the Playbook for continued NBA predictions, picks, and news.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
