A couple of old Pac-12 rivals meet in Seattle for a crucial Big Ten showdown on Saturday afternoon. The Oregon Ducks (10-1) make the short trip to face the Washington Huskies (8-3), looking to solidify a berth in the College Football Playoff.
The Ducks are on the outside looking in for the Big Ten title game with Ohio State and Indiana each undefeated in conference play. However, head coach Dan Lanning’s squad is riding a five-game winning streak since losing at home to the Hoosiers, 30-20, on October 11.
The Huskies have put together a solid season after not making a bowl game in 2024. Washington is off consecutive blowouts of Purdue and UCLA after getting shocked by Wisconsin on November 8 as 11-point favorites in a 13-10 defeat.
Let’s dive into this Oregon vs. Washington prediction for Saturday’s battle that kicking off at 3:30 p.m. ET on CBS at Alaska Airlines Field at Husky Stadium in Seattle. Use PrizePicks CFB to win real-money rewards if your picks are right.

The Ducks have won at least 10 games in five consecutive years and look to beat Washington for a second straight season.
Oregon enters this matchup as 7.5-point favorites, returning a 1.33x payout on PrizePicks Team Picks if they win outright.
The Huskies are home underdogs with a 3.12x payout if they win, via PrizePicks Team Picks.
- Spread: Oregon Ducks -7.5
- Total: 52.5
- Game Winner Payout: Oregon 1.33x | Washington 3.12x
(Data via PrizePicks Team Picks)
Here are some stats to know to get you set for Oregon vs. Washington, including insights on our prediction.
- The Ducks have picked up their offense the last two weeks, scoring 42 points apiece in home victories over Minnesota and USC.
- Prior to those outbursts, Oregon needed a last-second field goal to edge Iowa, 18-16, and some muscle to slide by Wisconsin, 21-7.
- After outlasting Penn State in double-OT on September 27, the Ducks went through a four-game stretch of covering the spread only one time.
- Oregon bounced back in the past two games, easily covering against the Gophers and Trojans.
- Washington couldn’t get any offense going in a 13-10 loss to a 4-7 Wisconsin squad on November 8, even though the Huskies outgained the Badgers, 251-205.
- The offense rebounded in the past two games, routing Purdue, 49-13, before ripping up UCLA, 48-14. UW covered in each victory as a double-digit favorite.
- Washington defeated Oregon three straight times from 2022 through 2023, capped off by a victory in the final Pac-12 title game.
- The Ducks rolled past the Huskies in their initial Big Ten matchup last November in Eugene, 49-21.
Oregon Ducks
- The Ducks have failed to cover the spread in two opportunities as a single-digit favorite. Oregon closed as a 4.5-point favorite in the 18-16 squeaker against Iowa and was a 7-point favorite in the 30-20 home defeat to Indiana.
- The offense ranks second in the nation in EPA/play, including 11th in EPA/pass.
- Oregon is 13th in defense success rate, an improvement from 50th last season when they finished as the top overall seed in the College Football Playoff.
Washington Huskies
- The Huskies are fifth in offense success rate and 16th in net EPA/play.
- Washington has been listed as an underdog twice, losing each time to Ohio State, 24-6 and Michigan, 24-7.
- Dating back to 2024, the Huskies are 1-7 both straight-up and against the spread in the underdog role.
Oregon vs. Washington Prediction
Below are the top CFB DFS picks for Saturday afternoon’s battle between Oregon and Washington.
Oregon QB Dante Moore Projection: 215.5 Passing Yards
- In his first season as the starter, Moore has posted 2,447 passing yards and 23 TDs.
- Moore racked up 257 passing yards in last Saturday’s win over USC, his sixth performance of at least 216 passing yards.
- Washington hasn’t allowed an opposing QB to throw for more than 200 yards in four straight games. The last three teams ranked 100th or worse in EPA/pass, compared to Oregon’s 22nd ranking.
- In three of four road games, the junior has completed 16 or fewer passes. In two of those matchups at Northwestern and Iowa, he finished with fewer than 200 passing yards.
Oregon RB Noah Whittington Projection: 76.5 Rushing Yards
- The senior ranks ninth in the Big Ten in rushing with 727 yards. He is 53 yards shy of setting a career-high, which came in his debut season with Oregon in 2022.
- Whittington posted his third 100+ yard rushing output against USC, putting up 104 yards on 19 carries.
- His first two 100+ yard performances came on the road, compiling 118 yards at Iowa and 125 yards at Rutgers.
- Washington boasts the 16th-best EPA/rush defensively. The last running back to rush for at least 77 yards against the Huskies was Michigan’s Jordan Marshall, who went for 133 yards in a 24-7 win on October 18.
Washington WR Denzel Boston Projection: 61.5 Receiving Yards
- Boston sits seventh in the Big Ten with 730 receiving yards in his junior season.
- He missed the last two games with a lower-body injury after picking up 62 yards in the loss at Wisconsin.
- The speedster's best performance came in a 42-25 rout of Illinois last month, bringing in 153 yards on 10 receptions.
- In last season’s loss to Oregon, Boston was held to 43 yards on 3 catches. The Ducks haven’t allowed an opposing wide receiver to rack up more than 60 yards in four road games.

Oregon looks to keep its offense rolling against Washington in a Big Ten showdown on Saturday afternoon.
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