The Oklahoma State Cowboys (18-13) vs. the Colorado Buffaloes (17-14) caps Tuesday, March 10’s Big 12 Tournament schedule with a 9:30 p.m. ET tip-off on ESPN+.
NCAA Net Rankings have Oklahoma State 79th and Colorado 71st, putting each team outside the NCAA Tournament bubble. Stacking wins in the Big 12 Tournament could change the postseason outlook for either team.
Who could keep their season alive in our Oklahoma State vs. Colorado prediction on the spread on Tuesday, March 10? You can get in on the Big 12 Tournament action with game winners, spreads, and over/under predictions on PrizePicks Team Picks.
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Oklahoma State vs. Colorado Prediction, Spread, Over/Under – 3/10/26
Oklahoma State is 5-3 in the last eight head-to-head matchups. Since Colorado joined the Big 12 in 2024, the series is split at 1-1. The Buffaloes rolled to an 83-69 win as 3.5-point favorites on February 21 vs. Oklahoma State.
The Cowboys are 3-7 outright and 4-6 against the spread (ATS) in the last 10 games, while Colorado is 7-3 ATS in the same split.
Oklahoma State vs. Colorado Spread, Over/Under
Colorado is favored by 1.5 points vs. Oklahoma State, per PrizePicks Team Picks. The Buffaloes carry a 1.78x payout to win, compared to the Cowboys’ 2.08x payout to emerge victorious.
- Spread: Colorado Buffaloes -1.5
- Over/Under: 161.5
- Gamer Winner Payout: Oklahoma State 2.08x | Colorado 1.78x
Team picks data is live as of publishing and is subject to change.
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Oklahoma State vs. Colorado Prediction on Spread
Oklahoma State F Parsa Fallah, who ranks second on the team with 14.7 points per game (PPG), suffered a season-ending torn ACL injury on February 23. The Cowboys carry a 3-1 ATS record and logged 86.3 PPG over four games without Fallah, surpassing their 83.9 PPG for the season (94th percentile).
Colorado F Sebastian Rancik ranks third on the team with 12.3 PPG and is doubtful for tonight’s battle, per the Big 12 player availability report. He’s missed two consecutive games, but the Buffaloes still posted 85.5 PPG without Rancik in the rotation.
With that said, both offenses continue to produce despite notable injuries. Bart Torvik ranks OSU 65th in adjusted offensive efficiency—slightly behind Colorado at 56th.
On February 21, the Buffaloes cashed in 11-of-27 3-point shots (40.7%), while the Cowboys made only 5-of-23 attempts (21.7%). Colorado’s defense allows a 36.1% 3-point shot distribution (77th percentile), compared to Oklahoma State surrendering a 43.0% mark from beyond the arc (19th percentile).
The Cowboys rank in the 98th percentile of close-2 shot distribution, but Fallah’s injury is a major hit to the paint attack. Plus, Colorado F Bangot Dak anchors the Buffaloes’ rim protection with a solid 2.34 Defensive Bayesian Performance Rating (DBPR), per EvanMiya.
Similar to the regular-season clash, advantages in shot distributions could be the difference for Oklahoma State vs. Colorado predictions on PrizePicks Team Picks.
Make Oklahoma State vs. Colorado Picks on PrizePicks
Colorado cruised to victory vs. Oklahoma State in the regular season, and its hot ATS streak provides further support for a potential win on Tuesday, March 10.
Make your Oklahoma State vs. Colorado picks and Big 12 Tournament predictions at PrizePicks and PrizePicks Team Picks, where you can earn real-money rewards for your predictions if you’re right.
Just choose players, predict More or Less on their projected stats, and follow the hoops action to see if your picks hit. You can make picks on winners, spreads, and over/unders on Team Picks, now available in 35 states.
Keep tabs on the Playbook for continued college basketball predictions, picks, and news all the way through the NCAA Tournament.
