Diving into Week 2 of NFL preseason football on Saturday, we’re seeing more on-field action from more NFL starters, so what better time to drop some NFL DFS Preseason Week 2 picks and predictions?
Below, we'll give you the top NFL DFS Preseason Week 2 picks for PrizePicks, including four players to target in your NFL DFS Lineups today.
Week 2 of the NFL preseason offers a variety of games and projections you can choose to win real money on PrizePicks. Lock in your NFL preseason picks along with your NFLSZN lineups today.
NFL DFS Preseason Week 2 Picks – Saturday, August 16
Here are four of the top NFL preseason picks and predictions to target on PrizePicks. Use this analysis to help you build your on Saturday, August 16 Prize Picks NFL lineup. Click each pick to read more.
- Panthers RB Trevor Etienne — 21.5 Rush Yards
- Eagles QB Tanner McKee — 108.5 Pass Yards
- Vikings QB Sam Howell — 0.5 Passing TDs
- 49ers WR Jacob Cowing — 21.5 Receiving Yards
Panthers RB Trevor Etienne — 21.5 Rush Yards
Panthers vs. Texans Prediction — 1 p.m. ET

- With Trevor Etienne listed as the third string running back on the depth chart, I expect him to see limited action against the Texans.
- Coach DeMeco Ryans said he plans to ramp up Texan starter snaps, which means Etienne will share time with fellow RBs Chuba Hubbard and Rico Dowdle, plus the reserves fighting for a roster spot.
- The Texans finished tenth in yards per attempt allowed at 4.3 per carry, another problem for Jacksonville's backfield.
Eagles QB Tanner McKee — 108.5 Pass Yards
Eagles vs. Browns Prediction — 1 p.m. ET

- Tanner McKee dominated the Bengals’ defense last week in Philly's first preseason game, racking up 252 passing yards and 3 touchdowns.
- Many, if not all starters from both sides will be resting as Browns head coach Kevin Stefanski has ruled out, among others, EDGE Myles Garrett.
- McKee's ability to control the pace of the game is exceptional, allowing plenty of opportunity for statistical glory.
Vikings QB Sam Howell — 0.5 Passing TDs
Vikings vs. Patriots Prediction — 1 p.m. ET

- Vikings head coach Kevin O’Connell said earlier this week that his three QBs will play in the preseason game against the Patriots. A fair guesstimate would be around one quarter apiece.
- The Patriots allowed the tenth-most passing touchdowns with 27 last season, which could open up the passing game for the Vikes’ offense.
- Pats head coach Mike Vrabel said that some starters will continue to play along with quarterback Drake Maye and Will Campbell. The inclusion of first stringers could stall the Vikings’ offense, giving Howell less opportunities.
- The Patriots were one of the slower teams in the NFL last season, as they ran the seventh fewest plays with 60.4 per game. This could be problematic against a tough Vikings defense.
49ers WR Jacob Cowing — 21.5 Receiving Yards
49ers vs. Raiders Prediction — 4:05 p.m. ET

- The 49ers have been plagued by injuries, as WR Jauan Jennings and RB Isaac Guerendo join WR Brandon Aiyuk on the injury report.
- Some starters, including QB Brock Purdy are expected to play, which could elevate the numbers of the receiving corps, WR Jacob Cowing included.
- Cowing has been dealing with a hamstring injury, he sat out in NFL Week 1 but seems like he'll good to go.
Play Preseason NFL DFS Today on PrizePicks
NFL preseason is officially in full swing for Week 2, with 11 NFL preseason games on Sautday, August 16. That means NFL DFS is back — and so is PrizePicks' real money fantasy sports game.
Build your NFL preseason Lineup today on PrizePicks with your favorite NFL players and win real money if your picks are correct. All you have to do is pick More or Less on at least two player projections — like passing touchdowns or rush yards— to win.
Stay locked in on PrizePicks Playbook all season long for NFL DFS picks every day.